Product image of Olmita (Olmesartan Medoxomil, Amlodipine) supplied by GNH India

Olmita

Active Ingredient:
Olmesartan Medoxomil, Amlodipine
Origin:
EU

Olmita (Olmesartan Medoxomil, Amlodipine)

Olmesartan medoxomil, the active ingredient in Olmita, is a angiotensin II receptor blocker presented as a tablet for oral use. It treats hypertension and is often prescribed for adults needing blood pressure control. GNH India supplies Olmita as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals and pharmacies worldwide.

GNH India supplies Olmita as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals and pharmacies worldwide.

Manufacturer / TM Owner

Krka, D.D., Novo Mesto

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Indications & Clinical Uses

Olmita combines two antihypertensive agents that act on the renin‑angiotensin system and vascular smooth‑muscle tone to lower blood pressure.

  • Hypertension: helps achieve target blood pressure in adults with primary hypertension.
  • High‑risk cardiovascular patients: contributes to risk reduction when used with lifestyle measures.
  • Resistant hypertension adjunct: can be added when blood pressure remains uncontrolled on monotherapy.

How It Works

  • Olmesartan medoxomil blocks the angiotensin II type 1 (AT1) receptor, preventing vasoconstriction and aldosterone release, while amlodipine inhibits L‑type calcium channels in vascular smooth muscle, causing arterial dilation. The combined effect reduces systemic vascular resistance and lowers arterial pressure.

Side Effects

Olmita may cause a range of adverse reactions, from mild to serious.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Peripheral edema: swelling of the ankles or lower legs.
  • Dizziness or light‑headedness: especially after standing.
  • Flushing: transient warmth and redness.
  • Fatigue: general tiredness.
  • Nausea: occasional stomach upset.

Serious or Rare Side Effects

  • Angio‑edema: rapid swelling of face, lips, tongue or throat.
  • Severe hypotension: marked drop in blood pressure causing fainting.
  • Liver enzyme elevation: abnormal liver function tests.
  • Renal impairment: worsening kidney function.
  • Hyperkalemia: elevated potassium levels.
  • Allergic rash: severe skin reactions such as Stevens‑Johnson syndrome.

Precautions & Warnings

When prescribing Olmita, clinicians should consider several safety aspects.

  • Pregnancy contraindication: avoid use in pregnancy due to fetal risk.
  • Renal impairment: adjust therapy based on kidney function.
  • Hepatic impairment: use with caution in patients with liver disease.
  • Electrolyte monitoring: check potassium levels periodically.
  • Drug‑interaction vigilance: review concomitant medications for additive hypotensive effects.
  • Store at ambient temperature: keep below 25°C, in the original packaging, protected from moisture.

Avoid Interactions

Olmita can interact with several drug classes, requiring careful management.

Major Interactions (Avoid)

  • Dual renin‑angiotensin system blockade: avoid concurrent ACE inhibitors or other ARBs.
  • Potassium‑sparing diuretics or supplements: risk of hyper‑kalemia.
  • Strong CYP3A4 inhibitors (e.g., itraconazole): may increase amlodipine levels.

Moderate Interactions (Monitor Closely)

  • Non‑steroidal anti‑inflammatory drugs (NSAIDs): may blunt antihypertensive effect.
  • Diuretics: may enhance hypotensive response.
  • Lithium: monitor lithium levels for potential toxicity.

Frequently Asked Questions

Olmita is a fixed‑dose combination of olmesartan medoxomil and amlodipine that is prescribed to lower high blood pressure in adults. By targeting two complementary pathways that control vascular tone, it helps patients achieve recommended blood‑pressure targets and reduces the risk of cardiovascular complications associated with hypertension.

Olmesartan medoxomil is an angiotensin II receptor blocker (ARB). It selectively blocks the AT1 receptor, preventing angiotensin II from causing vasoconstriction and stimulating aldosterone release. This results in relaxed blood vessels and reduced fluid retention, which together lower systemic blood pressure.

The dose of Olmita is individualized by a prescriber based on the patient’s blood‑pressure level, response to therapy, and any co‑existing medical conditions. Healthcare professionals determine the appropriate strength and dosing schedule, which is typically taken once daily.

Olmita is contraindicated in pregnancy because the ARB component can cause fetal harm, especially in the second and third trimesters. Breastfeeding is not recommended without medical advice, as the drugs may pass into milk and affect the infant. Women who are pregnant, planning pregnancy, or nursing should discuss alternatives with their healthcare provider.

To request Olmita, visit the product page on gnhindia.com, enter the required quantity, and submit the enquiry form. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Olmita combines an ARB (olmesartan) with a calcium‑channel blocker (amlodipine), offering dual‑mechanism blood‑pressure control in a single tablet. Compared with monotherapy, the combination can provide greater efficacy, simplify dosing, and improve adherence. Alternatives may include ACE‑inhibitor/CCB combos or separate tablets, but the fixed‑dose format reduces pill burden.

Olmita tablets should be stored at ambient temperature, below 25 °C, in the original container to protect them from moisture and light. Keep the product out of reach of children and avoid storing in areas with high humidity or extreme temperatures.

Olmita is taken orally, usually once daily, with or without food. Swallow the tablet whole with a glass of water. Patients should follow the prescribing clinician’s instructions regarding timing and any specific dietary considerations.

The most serious risks include angio‑edema, severe hypotension, significant kidney function decline, and hyper‑kalemia. Patients should be educated to seek immediate medical attention if they experience rapid swelling of the face, lips or throat, fainting, or any signs of allergic reaction.

Olmita should not be used by individuals who are pregnant, have known hypersensitivity to olmesartan, amlodipine or any excipients, or are currently receiving another ARB, ACE inhibitor, or direct renin inhibitor. Caution is also advised for patients with severe renal or hepatic impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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