Olvion (Sildenafil)

Olvion is a PDE5 inhibitor used in the management of conditions affecting the male sexual response pathway.

• Erectile dysfunction: improves ability to achieve and maintain an erection suitable for sexual activity.
• Pulmonary arterial hypertension: helps lower pulmonary arterial pressure and improve exercise capacity.
• Secondary Raynaud's phenomenon: may reduce frequency of vasospastic attacks in affected individuals.
• Benign prostatic hyperplasia (BPT) associated lower urinary tract symptoms: may provide modest improvement in urinary flow.
• Male infertility related to erectile dysfunction: supports sexual performance that can aid natural conception.
• Psychological erectile dysfunction: assists when performance anxiety contributes to the condition.

• Sildenafil selectively inhibits the enzyme phosphodiesterase type 5, preventing the breakdown of cyclic guanosine monophosphate (cGMP) in smooth‑muscle cells. Elevated cGMP levels cause relaxation of vascular smooth muscle and dilation of blood vessels, particularly in the corpus cavernosum and pulmonary vasculature, facilitating increased blood flow that underlies its therapeutic effects.

Olvion may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

• Headache: mild to moderate intensity.
• Flushing: warmth and redness, typically on the face or neck.
• Dyspepsia: indigestion or upset stomach.
• Nasal congestion: stuffy or runny nose.
• Visual disturbances: blurred vision or changes in colour perception.
• Myalgia: muscle aches, often in the back or limbs.

Serious or Rare Side Effects

• Sudden loss of vision (non‑arteritic anterior ischemic optic neuropathy).
• Sudden hearing loss or ringing in the ears.
• Priapism: prolonged erection lasting more than four hours.
• Severe hypotension: marked drop in blood pressure, especially with nitrates.
• Cardiac arrhythmia: irregular heart rhythm in susceptible individuals.
• Allergic reaction: rash, itching, swelling, or difficulty breathing.

Before prescribing Olvion, clinicians should assess cardiovascular status and review concomitant medications.

• Cardiovascular disease: evaluate risk of myocardial ischemia during sexual activity.
• Nitrate therapy: avoid co‑administration due to risk of severe hypotension.
• Alpha‑blockers: use with caution, monitor blood pressure closely.
• Liver or kidney impairment: consider dose adjustment and monitor function.
• Visual or auditory disorders: assess baseline status and monitor for changes.
• Store at below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Olvion can interact with several drug classes, requiring careful management.

Major Interactions (Avoid)

• Nitrates: concurrent use can cause profound hypotension.
• Guanylate cyclase stimulators: may amplify vasodilatory effects.
• Certain antifungal agents (e.g., ketoconazole): increase sildenafil plasma levels.

Moderate Interactions (Monitor Closely)

• Alpha‑blockers: may cause additive blood pressure lowering.
• Antihypertensives: monitor for enhanced hypotensive response.
• Protease inhibitors (e.g., ritonavir): may raise sildenafil concentrations.
• Macrolide antibiotics (e.g., erythromycin): potential increase in drug exposure.