Olvorin 300mg (Leucovorin Calcium Vials) 300/30ml

Olvorin 300mg (Leucovorin Calcium) is a folate derivative used to reduce toxic effects of folate antagonists like methotrexate. It supports healthy cell function during chemotherapy. This 300mg strength comes in 30ml vials for intravenous use. Suitable for patients requiring folinic acid rescue.

Strength

300/30ml

Pack Size

Storage

Ambient

Manufacturer / TM Owner

Beta Drugs Ltd

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Indications & Clinical Uses

Olvorin 300mg is primarily used to counteract the effects of folic acid antagonists such as methotrexate in chemotherapy regimens. It is also employed to treat megaloblastic anemia caused by folate deficiency when oral therapy is not feasible. The drug supports DNA synthesis and cell division in rapidly dividing tissues. It may be used in combination with 5-fluorouracil for colorectal cancer treatment.

Side Effects

Olvorin 300mg helps restore normal folate levels in the body, supporting healthy cell function and division. It may reduce side effects associated with high-dose methotrexate therapy by rescuing normal cells. Some patients report improved energy levels and reduced fatigue when used as directed. The medication works gradually to replenish folate stores over time.

Precautions & Warnings

Olvorin 300mg should be handled with care and administered by a healthcare professional. Patients with pernicious anemia or vitamin B12 deficiency should use this medication cautiously. Keep vials stored at room temperature away from moisture and direct light. Always check the solution for particles or discoloration before use. Discard any unused portion after opening.

Avoid Interactions

Olvorin 300mg may interact with certain antibiotics like trimethoprim and pyrimethamine, reducing its effectiveness. Combining with phenytoin or primidone may lower seizure control. Alcohol consumption should be avoided as it may interfere with folate metabolism. Always inform your healthcare provider about all medications being taken.

References

Frequently Asked Questions

Olvorin 300mg is used to reduce toxic effects of folate antagonists like methotrexate and to treat certain types of anemia.

Olvorin 300mg is given as an intravenous injection or infusion by a healthcare professional.

Olvorin 300mg should only be used during pregnancy if clearly needed and prescribed by a doctor.

Common effects may include nausea, vomiting, or allergic reactions; report any unusual symptoms to a healthcare provider.

It may interact with certain drugs; always consult your healthcare provider before combining medications.

Published by GNH India Pharmaceuticals Limited

Last updated: 17 Jun 2026

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