Product image of Omacor (Omega-3-Acid Ethyl Esters 90) supplied by GNH India

Omacor

Active Ingredient:
Omega-3-Acid Ethyl Esters 90
Origin:
EU

Omacor (Omega-3-Acid Ethyl Esters 90)

Omega-3-acid ethyl esters, the active ingredient in Omacor, is a prescription omega-3 fatty acid presented as an oral capsule for oral use. It is indicated for the management of markedly elevated triglyceride levels in adult patients.
GNH India supplies Omacor as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

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Indications & Clinical Uses

  • Omacor is a prescription omega‑3 fatty acid that acts on triglyceride metabolism to lower serum triglyceride concentrations.
  • Hypertriglyceridemia: reduces markedly elevated triglyceride levels in adults.
  • Severe hypertriglyceridemia: helps lower triglycerides to reduce the risk of pancreatitis.
  • Adjunct to diet: used together with a low‑fat diet to improve lipid profiles in patients with very high triglycerides.

How It Works

  • Omega-3-acid ethyl esters are hydrolysed after oral absorption to eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). EPA and DHA inhibit hepatic very‑low‑density lipoprotein (VLDL) synthesis, enhance beta‑oxidation of fatty acids, and reduce the activity of diacylglycerol O‑acyltransferase, leading to decreased hepatic triglyceride production and lower circulating triglyceride concentrations.

Side Effects

Common Side Effects

  • Fish‑oil aftertaste or eructation
  • Nausea or mild gastrointestinal discomfort
  • Diarrhoea or loose stools
  • Dyspepsia or abdominal bloating
  • Headache
  • Mild increase in serum glucose

Serious or Rare Side Effects

  • Pancreatitis
  • Severe allergic reactions (rash, angioedema, anaphylaxis)
  • Elevated liver enzymes (hepatitis)
  • Bleeding complications, especially when combined with anticoagulants
  • Atrial fibrillation or cardiac arrhythmias
  • Severe hyperglycaemia in diabetic patients

Precautions & Warnings

  • Before initiating Omacor, clinicians should assess baseline triglyceride levels, liver function, and bleeding risk.
  • Monitor triglyceride response: adjust therapy based on serial lipid panels.
  • Assess bleeding risk: caution in patients on anticoagulants or antiplatelet agents.
  • Evaluate liver function: periodic testing is advised.
  • Pregnancy and lactation: use only if potential benefit outweighs risk.
  • Review concomitant omega‑3 supplements: avoid excessive dosing.
  • Store at below 25°C: keep in the original pack, protect from moisture and direct sunlight.

Avoid Interactions

Omacor may interact with several drug classes; awareness of interaction severity guides clinical decisions.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin, direct oral anticoagulants): increased bleeding risk.
  • High‑dose omega‑3 supplements: risk of excessive omega‑3 exposure.
  • Niacin at high doses: potential additive hepatotoxicity.

Moderate Interactions (Monitor Closely)

  • Statins: possible increased risk of myopathy.
  • Fibrates: may raise risk of gallstone formation.
  • Cyclosporine: can elevate plasma omega‑3 levels.
  • Antihypertensive agents: may modestly enhance blood‑pressure‑lowering effect.

Frequently Asked Questions

Omacor is a prescription omega‑3 fatty acid medication used primarily to lower markedly elevated triglyceride levels in adult patients, including those with severe hypertriglyceridemia where the risk of pancreatitis is a concern. It is prescribed as an adjunct to a low‑fat diet to improve lipid profiles.

After oral ingestion, Omega-3-acid ethyl esters are converted to EPA and DHA, which inhibit hepatic VLDL synthesis, increase fatty‑acid beta‑oxidation, and reduce the activity of enzymes involved in triglyceride production. These actions collectively lower circulating triglyceride concentrations.

The exact dose of Omacor is individualized by the prescribing clinician based on the patient’s triglyceride level, response to therapy, and overall clinical profile. Dosage decisions consider factors such as baseline lipid values, concomitant medications, and any existing comorbidities.

Omacor should be used during pregnancy or lactation only if the potential therapeutic benefit justifies any possible risk to the fetus or infant. Health professionals typically evaluate the risk‑benefit ratio on a case‑by‑case basis and may consider alternative lipid‑lowering strategies when appropriate.

To place an order, submit an enquiry on the Omacor product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Omacur contains prescription‑strength omega‑3‑acid ethyl esters, delivering higher EPA/DHA concentrations than most over‑the‑counter fish‑oil supplements. This higher potency enables more reliable triglyceride reduction, but it also requires medical supervision and monitoring for potential interactions and adverse effects.

Omacor should be stored at temperatures below 25 °C, in its original packaging, protected from moisture and direct sunlight. Keeping the product in a stable environment helps maintain its potency and prevents degradation of the ethyl‑ester formulation.

Omacor is taken orally, usually with meals to improve tolerability and absorption. The capsules are swallowed whole with water; they should not be opened, crushed, or mixed with other substances unless specifically instructed by a healthcare professional.

The most serious risks include pancreatitis, severe allergic reactions (such as anaphylaxis), significant bleeding events—especially when combined with anticoagulants—and hepatic injury indicated by elevated liver enzymes. Patients should be monitored regularly for these potential complications.

Omacor is contraindicated in patients with known hypersensitivity to omega‑3 fatty acids or any capsule excipients. It should also be avoided in individuals with active bleeding disorders, severe liver disease, or those who are currently taking high‑dose omega‑3 supplements without medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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