Product image of Omegaven (Glycerol, Highly Refined Fish Oil, Purified Egg Phospholipids) supplied by GNH India

Omegaven

Active Ingredient:
Glycerol, Highly Refined Fish Oil, Purified Egg Phospholipids
Origin:
EU

Omegaven (Glycerol, Highly Refined Fish Oil, Purified Egg Phospholipids)

Omegaven, the active ingredient in Omegaven, is a lipid emulsion presented as an unspecified strength intravenous emulsion for intravenous use. It provides essential omega‑3 fatty acids and calories to patients requiring parenteral lipid supplementation, such as those with essential fatty acid deficiency or parenteral nutrition‑associated liver disease.

GNH India supplies Omegaven as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres and oncology centres worldwide.

Manufacturer / TM Owner

Fresenius Kabi Deutschland Gmbh

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Indications & Clinical Uses

Omegaven is used in clinical nutrition to address lipid needs and related metabolic conditions.

  • Parenteral nutrition lipid supplementation: supplies calories and essential omega‑3 fatty acids to patients receiving total parenteral nutrition.
  • Essential fatty acid deficiency: prevents and treats deficiency in patients unable to obtain fatty acids enterally.
  • Parenteral nutrition‑associated liver disease: helps manage liver dysfunction linked to long‑term parenteral nutrition.
  • Severe hypertriglyceridaemia requiring fish‑oil based support: provides a fish‑oil lipid source for patients with high triglycerides who need lipid infusion.

How It Works

  • Omegaven delivers highly refined fish oil, glycerol and purified egg phospholipids intravenously, providing EPA and DHA that become incorporated into cell membranes. These omega‑3 fatty acids modulate eicosanoid synthesis, reduce inflammatory cytokine production, and supply essential fatty acids and caloric energy, thereby supporting membrane integrity and metabolic needs in patients receiving parenteral nutrition.

Side Effects

Common Side Effects

  • Fever or chills during infusion.
  • Mild infusion‑site erythema or pain.
  • Transient elevation of liver enzymes.
  • Mild hypertriglyceridaemia.
  • Slight thrombocytopenia.

Serious or Rare Side Effects

  • Fat overload syndrome leading to organ dysfunction.
  • Anaphylactic or severe allergic reactions.
  • Severe hypertriglyceridaemia with pancreatitis risk.
  • Coagulopathy or bleeding complications.
  • Infections related to lipid‑rich medium.

Precautions & Warnings

Before initiating Omegaven, clinicians should consider several safety measures.

  • Monitor triglyceride levels: check serum triglycerides regularly during therapy.
  • Assess liver function: perform baseline and periodic liver enzyme tests.
  • Allergy screening: avoid use in patients with known fish or egg phospholipid hypersensitivity.
  • Caution in severe hyperlipidaemia: weigh benefits against risk of fat overload.
  • Adjust in metabolic impairment: consider dose modification for hepatic or renal dysfunction.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Omegaven may interact with other agents that affect lipid metabolism or coagulation.

Major Interactions (Avoid)

  • Concurrent lipid emulsions: risk of cumulative fat overload.
  • Propofol infusion: excessive lipid load may precipitate hypertriglyceridaemia.
  • High‑dose anticoagulants: potential for enhanced bleeding.

Moderate Interactions (Monitor Closely)

  • Fibrates or niacin: may amplify triglyceride‑lowering effects, requiring monitoring.
  • Statins: combined use may increase risk of muscle toxicity.
  • Immunosuppressants: monitor for altered drug levels due to changes in plasma protein binding.

Frequently Asked Questions

Omegaven is an intravenous lipid emulsion used in parenteral nutrition to provide essential omega‑3 fatty acids and calories. It is indicated for patients who need lipid supplementation, those with essential fatty acid deficiency, individuals with parenteral nutrition‑associated liver disease, and patients with severe hypertriglyceridaemia who require a fish‑oil based lipid source.

Omegaven supplies highly refined fish oil, glycerol and purified egg phospholipids directly into the bloodstream. The omega‑3 fatty acids (EPA and DHA) become part of cell membranes, modulating inflammatory pathways, supporting membrane integrity, and delivering essential fatty acids and energy needed for patients who cannot receive nutrition enterally.

The dose of Omegaven is individualized by the prescribing clinician based on the patient’s caloric needs, lipid requirements, and clinical condition. Healthcare professionals calculate the appropriate volume and infusion rate according to established parenteral nutrition protocols and laboratory monitoring.

Safety data for Omegaven in pregnancy and lactation are limited, and the product’s pregnancy category is not established. Use during pregnancy or while breastfeeding should only occur if the potential benefits justify any potential risk, and it must be decided by the treating physician.

To order Omegaven, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain logistics) and any necessary import documentation.

Omegaven is distinguished by its high content of omega‑3 fatty acids from fish oil, which offers anti‑inflammatory benefits and a different fatty‑acid profile compared with traditional soybean‑based emulsions. This can result in lower triglyceride levels and reduced risk of liver dysfunction, making it a preferred option for patients at risk of inflammation‑related complications.

Omegaven must be stored at 2‑8 °C in a refrigerator. Keep the container in its original packaging, protect it from light, and avoid freezing or vigorous shaking. Before use, gently invert the bag to ensure uniform suspension of the emulsion.

Omegaven is administered intravenously as a sterile emulsion, typically infused through a central venous catheter as part of a total parenteral nutrition regimen. The infusion rate and total daily volume are determined by the prescribing clinician and are adjusted according to the patient’s metabolic response and laboratory results.

Serious risks include fat overload syndrome, severe hypertriglyceridaemia that can lead to pancreatitis, anaphylactic reactions, coagulopathy, and infection related to the lipid medium. Clinicians should monitor triglyceride levels, liver function, coagulation parameters and observe patients for any signs of allergic response during infusion.

Omegaven should be avoided in patients with known hypersensitivity to fish oil, egg phospholipids, or any component of the formulation. It is also contraindicated in individuals with severe hyperlipidaemia where the risk of fat overload outweighs benefits, and in patients with uncontrolled sepsis or active infection where lipid infusion could exacerbate the condition.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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