Product image of Omeprazol Actavis (Omeprazole) supplied by GNH India

Omeprazol Actavis

Active Ingredient:
Omeprazole
Origin:
EU

Omeprazol Actavis (Omeprazole)

Omeprazole, the active ingredient in Omeprazol Actavis, is a proton pump inhibitor presented as an oral dosage form for oral use. It reduces gastric acid production and is used to treat conditions such as gastro‑oesophageal reflux disease and peptic ulcer disease.

GNH India supplies Omeprazol Actavis as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Teva B.V

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Indications & Clinical Uses

Omeprazol Actavis is a proton pump inhibitor that lowers gastric acidity in several gastrointestinal disorders.

  • Gastroesophageal reflux disease (GERD): alleviates heartburn and acid regurgitation by decreasing stomach acid.
  • Peptic ulcer disease: promotes ulcer healing and prevents recurrence through acid suppression.
  • Helicobacter pylori eradication: used in combination therapy to enhance bacterial clearance.
  • Erosive esophagitis: heals inflamed esophageal tissue by maintaining a less acidic environment.

How It Works

  • Omeprazole irreversibly binds to the H+/K+ ATPase enzyme (the gastric proton pump) located on the secretory surface of parietal cells. By inhibiting this final step of acid secretion, it markedly reduces both basal and stimulated gastric acid output, leading to increased gastric pH and facilitating mucosal healing.

Side Effects

Adverse reactions may occur with omeprazole therapy.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Diarrhea: loose stools, usually transient.
  • Nausea: occasional feeling of stomach upset.
  • Abdominal pain: cramping or discomfort.

Serious or Rare Side Effects

  • Severe allergic reaction: rash, itching, swelling, or difficulty breathing.
  • Clostridioides difficile infection: persistent watery diarrhea.
  • Low magnesium levels: muscle cramps, irregular heartbeat.
  • Bone fractures: increased risk with long‑term use.
  • Liver enzyme elevation: abnormal liver function tests.

Precautions & Warnings

Before initiating therapy, consider the following safety measures.

  • Assess renal and hepatic function: adjust use if impairment is present.
  • Review concomitant medications: avoid drugs that require gastric acidity for absorption.
  • Monitor for infection signs: prolonged acid suppression may increase gastrointestinal infection risk.
  • Evaluate long‑term use: consider bone health monitoring after extended therapy.
  • Store at ambient temperature: keep below 25°C in the original packaging, protect from moisture and light.

Avoid Interactions

Omeprazole can affect the plasma concentrations of several co‑administered drugs.

Major Interactions (Avoid)

  • Clopidogrel: reduced antiplatelet effect, may increase cardiovascular event risk.
  • Atazanavir: markedly decreased antiviral efficacy due to reduced absorption.

Moderate Interactions (Monitor Closely)

  • Warfarin: potential increase in INR, monitor coagulation parameters.
  • Methotrexate (high dose): possible increased toxicity, check serum levels.
  • Digoxin: may raise serum concentrations, observe for signs of toxicity.

Frequently Asked Questions

Omeprazol Actavis is prescribed to manage gastro‑oesophageal reflux disease, peptic ulcer disease, Helicobacter pylori eradication regimens, and erosive esophagitis. By lowering stomach acid, it helps relieve symptoms, promotes ulcer healing, and supports the effectiveness of antibiotic combinations for H. pylori infection.

Omeprazole targets the H+/K+ ATPase enzyme, also known as the gastric proton pump, on parietal cells. By irreversibly inhibiting this pump, it blocks the final step of acid secretion, leading to a sustained increase in gastric pH and reduced acidity.

The appropriate dose of Omeprazol Actavis is determined by the prescribing healthcare professional based on the specific indication, patient age, renal and hepatic function, and treatment duration. Patients should follow the prescriber’s instructions and not alter the dose on their own.

Safety data for omeprazole in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Omeprazole belongs to the proton pump inhibitor class, offering more potent and longer‑lasting acid suppression than H2‑receptor antagonists such as ranitidine. Compared with newer PPIs, it has a well‑established efficacy and safety profile, making it a common first‑line choice for acid‑related disorders.

Store Omeprazol Actavis at ambient temperature, preferably below 25 °C. Keep the product in its original container, protect it from moisture and direct sunlight, and ensure the packaging remains tightly closed until use.

Omeprazol Actavis is taken orally, usually as a whole tablet swallowed with water. It is generally recommended to take the dose before a meal, most commonly before breakfast, unless the prescriber advises otherwise.

Serious risks include severe allergic reactions such as anaphylaxis, Clostridioides difficile‑associated diarrhea, low magnesium levels that can cause muscle cramps or cardiac arrhythmias, and an increased risk of bone fractures with long‑term use. Patients should seek immediate medical attention if any of these occur.

Individuals with known hypersensitivity to omeprazole or any component of the formulation should avoid its use. Caution is also advised for patients with severe liver disease, those taking medications that require gastric acidity for absorption, and patients with a history of osteoporosis when long‑term therapy is considered.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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