Product image of Omeprazol Pharmazone (Omeprazole) supplied by GNH India

Omeprazol Pharmazone

Active Ingredient:
Omeprazole
Origin:
EU

Omeprazol Pharmazone (Omeprazole)

Omeprazole, the active ingredient in Omeprazol Pharmazone, is a proton pump inhibitor presented as an oral tablet for oral use. It reduces gastric acid secretion and is employed in the management of acid‑related gastrointestinal disorders in adults.

GNH India supplies Omeprazol Pharmazone as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Pharmazone Portugal Unipessoal Lda.

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Indications & Clinical Uses

Omeprazole acts on the gastric acid secretion pathway and is indicated for several acid‑related conditions.

  • Gastro‑oesophageal reflux disease (GERD): alleviates heartburn and promotes healing of erosive oesophagitis.
  • Peptic ulcer disease: facilitates ulcer healing and reduces recurrence risk.
  • Helicobacter pylori eradication (in combination therapy): enhances eradication rates when used with antibiotics.
  • Zollinger‑Ellison syndrome: controls excessive gastric acid production in this rare endocrine disorder.

How It Works

  • Omeprazole selectively and irreversibly inhibits the H+/K+‑ATPase enzyme (the gastric proton pump) located on the secretory surface of parietal cells. By blocking this final step of acid secretion, it markedly reduces both basal and stimulated gastric acid output, leading to an increase in gastric pH and allowing mucosal healing in acid‑related conditions.

Side Effects

Omeprazole may be associated with a range of adverse reactions, most of which are mild and transient.

Common Side Effects

  • Headache: mild to moderate intensity, often transient.
  • Diarrhoea: loose stools that usually resolve without intervention.
  • Nausea or abdominal discomfort: occasional stomach upset.
  • Flatulence or constipation: changes in bowel habits.

Serious or Rare Side Effects

  • Clostridioides difficile infection: severe colitis requiring medical attention.
  • Low serum magnesium (hypomagnesemia): may cause muscle cramps, seizures, or cardiac arrhythmia.
  • Severe allergic reactions (anaphylaxis, Stevens‑Johnson syndrome): require immediate emergency care.

Precautions & Warnings

Before initiating therapy, consider the following safety measures.

  • Assess liver function: dose adjustment may be needed in severe hepatic impairment.
  • Evaluate renal status: monitor electrolytes during long‑term use.
  • Use the lowest effective dose: limit duration to the shortest period necessary to achieve therapeutic goals.
  • Pregnancy and lactation: prescribe only if the potential benefit justifies the potential risk to the fetus or infant.
  • Elderly patients: monitor for increased risk of fractures and renal complications.
  • Store at ambient temperature: keep below 25 °C in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Omeprazole can alter the pharmacokinetics of several co‑administered medicines.

Major Interactions (Avoid)

  • Clopidogrel: reduced antiplatelet effect may increase cardiovascular risk.
  • Ketoconazole, itraconazole, atazanavir: decreased absorption due to higher gastric pH.
  • Warfarin: potential increase in INR, requiring closer monitoring.

Moderate Interactions (Monitor Closely)

  • Digoxin: increased serum levels may necessitate dose adjustment.
  • Methotrexate (high‑dose): reduced clearance may raise toxicity risk.

Frequently Asked Questions

Omeprazol Pharmazone contains omeprazole, a proton pump inhibitor used to reduce gastric acid production. It is prescribed for conditions such as gastro‑oesophageal reflux disease, peptic ulcer disease, Helicobacter pylori eradication regimens, and Zollinger‑Ellison syndrome, helping to relieve symptoms and promote mucosal healing.

Omeprazole works by irreversibly binding to the H+/K+‑ATPase enzyme, also known as the gastric proton pump, on the secretory surface of parietal cells. This inhibition blocks the final step of acid secretion, leading to a sustained increase in gastric pH and allowing damaged tissue in the gastrointestinal tract to heal.

The appropriate dose of Omeprazol Pharmazone is determined by the prescribing healthcare professional based on the specific indication, patient characteristics, and treatment duration. Dosage may vary for conditions such as GERD, ulcer healing, or H. pylori eradication, and should follow the prescriber’s instructions.

Omeprazole is classified as a pregnancy category C drug, meaning it should be used only if the potential benefit justifies the potential risk to the fetus. Limited data are available for breastfeeding, and the drug does pass into breast milk in small amounts. Consultation with a healthcare provider is essential before use in these populations.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifying trade or institutional credentials before providing pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Omeprazol Pharmazone is a well‑established PPI with a pharmacokinetic profile similar to other agents such as esomeprazole or lansoprazole. While efficacy in acid suppression is comparable, differences may exist in onset of action, drug‑drug interaction potential, and individual patient tolerance. Choice of PPI often depends on clinician preference, patient response, and specific drug interaction considerations.

Store Omeprazol Pharmazone tablets at ambient temperature, preferably below 25 °C. Keep the product in its original packaging to protect it from moisture and direct sunlight. Do not store in a refrigerator or freezer, and ensure the container is tightly closed when not in use.

Omeprazol Pharmazone is taken orally, usually as a whole tablet swallowed with water. It is generally recommended to take the dose before a meal, often in the morning, unless the prescriber advises a different schedule. The tablet should not be crushed, chewed, or dissolved unless specifically instructed.

Serious risks, though uncommon, include Clostridioides difficile‑associated colitis, severe allergic reactions such as anaphylaxis or Stevens‑Johnson syndrome, and electrolyte disturbances like hypomagnesemia. Long‑term use may also be linked to increased fracture risk, vitamin B12 deficiency, and chronic kidney disease, so regular monitoring is advisable.

Patients with known hypersensitivity to omeprazole or any component of the formulation should avoid the product. Individuals taking clopidogrel for antiplatelet therapy, or those requiring drugs that depend on an acidic gastric environment for absorption, should discuss alternatives with their healthcare provider. Caution is also warranted in severe hepatic impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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