Product image of Omeprazol Polpharma (Omeprazole Sodium) supplied by GNH India

Omeprazol Polpharma

Active Ingredient:
Omeprazole Sodium
Origin:
EU

Omeprazol Polpharma (Omeprazole Sodium)

Omeprazole, the active ingredient in Omeprazol Polpharma, is a proton pump inhibitor presented as an intravenous solution for intravenous use. It reduces gastric acid secretion and is employed to treat peptic ulcer disease, gastro‑oesophageal reflux disease, Zollinger‑Ellison syndrome and to prevent NSAID‑induced gastric ulcers.

GNH India supplies Omeprazol Polpharma as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Zaklady Farmaceutyczne Polpharma S.A.

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Indications & Clinical Uses

Omeprazol Polpharma, a proton pump inhibitor, acts on conditions driven by excess gastric acid.

  • Peptic ulcer disease: lowers acid to promote ulcer healing.
  • Gastro‑oesophageal reflux disease (GERD): reduces reflux symptoms by decreasing acid exposure.
  • Zollinger‑Ellison syndrome: controls hyper‑secretion of gastric acid.
  • Prevention of NSAID‑induced gastric ulcers: safeguards the gastric mucosa during NSAID therapy.

How It Works

  • Omeprazole sodium irreversibly binds to the H+/K+ ATPase enzyme (gastric proton pump) located on the secretory surface of parietal cells. By inhibiting this final step of acid production, it markedly suppresses gastric acid secretion, leading to increased gastric pH and facilitating mucosal healing in acid‑related disorders.

Side Effects

Omeprazol Polpharma may cause a range of adverse reactions.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Diarrhea: loose stools occurring during therapy.
  • Nausea: feeling of sickness or upset stomach.
  • Abdominal pain: discomfort in the stomach area.
  • Flatulence: increased gas production.
  • Constipation: reduced bowel movements.

Serious or Rare Side Effects

  • Clostridioides difficile infection: severe colitis risk.
  • Anaphylaxis: life‑threatening allergic reaction.
  • Hepatic dysfunction: elevated liver enzymes or hepatitis.
  • Neutropenia: low neutrophil count increasing infection risk.
  • Thrombocytopenia: reduced platelet count causing bleeding.
  • Interstitial nephritis: kidney inflammation.

Precautions & Warnings

Before initiating therapy, consider the following precautions.

  • Renal impairment: monitor renal function and adjust therapy as needed.
  • Hepatic disease: use with caution; assess liver enzymes regularly.
  • Elderly patients: start at lower doses and observe for adverse effects.
  • Concomitant medications: review for potential drug interactions.
  • Pregnancy and lactation: safety not established; weigh benefits against risks.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Omeprazol Polpharma can affect the pharmacokinetics of several drugs.

Major Interactions (Avoid)

  • Clopidogrel: omeprazole reduces antiplatelet activity, increasing cardiovascular risk.
  • Atazanavir: decreased absorption leading to reduced antiviral efficacy.
  • Ketoconazole: reduced serum levels, compromising antifungal effect.

Moderate Interactions (Monitor Closely)

  • Warfarin: may increase INR, requiring closer coagulation monitoring.
  • Methotrexate: elevated levels can enhance toxicity.
  • Digoxin: increased serum concentration may necessitate dose adjustment.

Frequently Asked Questions

Omeprazol Polpharma is indicated for the management of peptic ulcer disease, gastro‑oesophageal reflux disease (GERD), Zollinger‑Ellison syndrome, and for the prevention of gastric ulcers associated with non‑steroidal anti‑inflammatory drug (NSAID) therapy. It works by reducing gastric acid secretion, which helps heal ulcers and alleviate reflux symptoms.

Omeprazole belongs to the proton pump inhibitor class. It irreversibly inhibits the H+/K+ ATPase enzyme, also known as the gastric proton pump, located on the secretory surface of parietal cells. This inhibition blocks the final step of acid production, leading to a sustained increase in gastric pH and reduced acid‑related damage.

The dosage of Omeprazol Polpharma is determined by the prescribing healthcare professional based on the specific indication, severity of the condition, patient weight, renal and hepatic function, and other clinical factors. The prescriber will set the appropriate dose and infusion rate for each individual patient.

Safety data for omeprazole in pregnancy and lactation are limited. The product should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant. Healthcare providers should evaluate each case individually and discuss potential risks with the patient.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide. After submission, the sales team will verify trade or institutional credentials, then provide pricing, availability, shipping details (including cold‑chain if required), and necessary import documentation.

Omeprazol Polpharma, as an intravenous proton pump inhibitor, offers rapid and potent suppression of gastric acid compared with oral PPIs or H2‑receptor antagonists. Its IV route is advantageous in patients who cannot take oral medications, have severe ulcer disease, or require immediate acid control, whereas oral agents are generally used for maintenance therapy.

Omeprazol Polpharma should be stored at 2‑8 °C in a refrigerator. Keep the solution in its original container, protect it from light, and avoid freezing or shaking. Do not use the product if it appears discolored or if the storage temperature has been exceeded.

The product is supplied as an intravenous solution and is administered by slow infusion into a vein, typically through a peripheral or central line. Administration should be performed by qualified healthcare personnel in a clinical setting, following the prescribing information for infusion rate and duration.

Serious adverse reactions, although rare, include Clostridioides difficile‑associated diarrhea, severe allergic reactions such as anaphylaxis, hepatic dysfunction, neutropenia, thrombocytopenia, and interstitial nephritis. Patients should be monitored for signs of infection, liver injury, blood count changes, and allergic responses during therapy.

Omeprazol Polpharma is contraindicated in patients with known hypersensitivity to omeprazole or any component of the formulation. Caution is advised for individuals with severe hepatic impairment, those receiving clopidogrel, and patients with a history of allergic reactions to proton pump inhibitors. The prescriber should assess suitability before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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