Product image of Omeprazol Zentiva (Omeprazole) supplied by GNH India

Omeprazol Zentiva

Active Ingredient:
Omeprazole
Origin:
EU

Omeprazol Zentiva (Omeprazole)

Omeprazole, the active ingredient in Omeprazol Zentiva, is a proton pump inhibitor presented as a tablet for oral use. It reduces stomach acid production and is used to treat conditions such as gastro‑oesophageal reflux disease and peptic ulcer disease in adults.

GNH India supplies Omeprazol Zentiva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Zentiva Portugal, Lda

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Indications & Clinical Uses

Omeprazol Zentiva is a proton pump inhibitor that acts on gastric acid secretion pathways. It is indicated for several acid‑related disorders:

  • Gastro‑oesophageal reflux disease (GERD): alleviates heartburn and promotes healing of the oesophageal lining.
  • Peptic ulcer disease: supports ulcer healing and reduces risk of recurrence.
  • Zollinger‑Ellison syndrome: controls excessive gastric acid production associated with this rare condition.
  • Helicobacter pylori eradication regimens: used as part of combination therapy to improve eradication rates.
  • NSAID‑induced ulcer prophylaxis: lowers the risk of ulcer development in patients requiring long‑term non‑steroidal anti‑inflammatory drugs.

How It Works

  • Omeprazole irreversibly binds to the H+/K+‑ATPase enzyme (the gastric proton pump) on the secretory surface of parietal cells, inhibiting the final step of acid secretion. This blockade reduces both basal and stimulated gastric acid output, allowing the gastrointestinal mucosa to heal and maintain a higher gastric pH.

Side Effects

Omeprazol Zentiva is generally well tolerated, but adverse reactions can occur.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Diarrhoea: usually self‑limiting.
  • Nausea or abdominal discomfort: transient gastrointestinal upset.
  • Flatulence: excess gas formation.
  • Constipation: occasional bowel habit changes.
  • Dry mouth: reduced salivary flow.

Serious or Rare Side Effects

  • Clostridioides difficile infection: severe colitis in susceptible individuals.
  • Acute interstitial nephritis: inflammation of kidney interstitium.
  • Hypomagnesemia: low serum magnesium with prolonged use.
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis: rare severe skin reactions.

Precautions & Warnings

Before initiating therapy with Omeprazol Zentiva, consider the following precautions:

  • Assess renal function: adjust use in severe renal impairment.
  • Evaluate hepatic function: use with caution in moderate to severe liver disease.
  • Review concomitant medications: potential for drug‑drug interactions.
  • Long‑term use: monitor for vitamin B12 deficiency and bone density loss.
  • Pregnancy and lactation: weigh benefits against potential risks.
  • Store at below 25°C: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Omeprazole may interact with several medicines, altering their absorption or metabolism.

Major Interactions (Avoid)

  • Clopidogrel: reduced antiplatelet effect, increasing cardiovascular risk.
  • Atazanavir and other protease inhibitors: decreased antiviral efficacy.
  • Methotrexate (high dose): increased serum levels, risk of toxicity.

Moderate Interactions (Monitor Closely)

  • Warfarin: potential increase in INR, requiring more frequent monitoring.
  • Phenytoin: reduced plasma concentrations, may diminish seizure control.
  • Digoxin: modest rise in serum levels, monitor for toxicity.

Frequently Asked Questions

Omeprazol Zentiva contains omeprazole, a proton pump inhibitor used to lower stomach acid. It is prescribed for conditions such as gastro‑oesophageal reflux disease, peptic ulcer disease, Zollinger‑Ellison syndrome, and as part of Helicobacter pylori eradication regimens or NSA‑related ulcer prophylaxis.

Omeprazole irreversibly inhibits the gastric H+/K+‑ATPase (proton pump) located on parietal cells. By blocking this final step of acid secretion, it raises gastric pH, allowing damaged mucosa to heal and reducing symptoms caused by excess acid.

The appropriate dose of Omeprazol Zentiva is determined by the prescribing clinician based on the specific indication, patient age, renal and hepatic function, and other individual factors. Patients should follow the prescriber’s instructions.

Omeprazole is classified as pregnancy category B in many regions, indicating no evidence of risk in animal studies but limited human data. It should be used during pregnancy or lactation only if the potential benefit justifies any potential risk to the fetus or infant.

To order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request trade or institutional credentials before providing pricing, availability, shipping details and any required import documentation.

Omeprazole belongs to the proton pump inhibitor class, which provides more potent and longer‑lasting acid suppression than H2‑receptor antagonists such as ranitidine. Compared with newer PPIs, omeprazole has a well‑established efficacy and safety profile, though individual response may vary.

Store tablets at temperatures below 25 °C in the original packaging, protecting them from moisture and direct sunlight. Keep the container tightly closed and out of reach of children.

Omeprazol Zentiva tablets are taken orally, usually before a meal. Swallow the tablet whole with water; do not crush or chew unless the product specification permits.

Serious but rare risks include Clostridioides difficile‑associated colitis, acute interstitial nephritis, severe hypomagnesemia, and rare skin reactions such as Stevens‑Johnson syndrome. Patients should seek medical attention if they experience severe diarrhea, rash, or unexplained swelling.

Individuals with known hypersensitivity to omeprazole, other PPIs, or any excipients in the tablet should avoid the product. Caution is also advised for patients with severe liver disease, and it should be used only under medical supervision in pregnant or breastfeeding women.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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