Product image of Omeprazol Zentiva (Omeprazole Sodium) supplied by GNH India

Omeprazol Zentiva

Active Ingredient:
Omeprazole Sodium
Origin:
EU

Omeprazol Zentiva (Omeprazole Sodium)

Omeprazole, the active ingredient in Omeprazol Zentiva, is a proton pump inhibitor presented as an intravenous solution for intravenous use. It is employed in the treatment of gastro‑esophageal reflux disease, healing of gastric and duodenal ulcers, prevention of NSAID‑induced ulcer recurrence, and management of Zollinger‑Ellison syndrome in adult patients.
GNH India supplies Omeprazol Zentiva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Zentiva, K.S.

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Indications & Clinical Uses

Omeprazol Zentiva, a proton pump inhibitor, acts on conditions involving excess gastric acid secretion.

  • Gastro‑esophageal reflux disease (GERD): reduces acid exposure to the esophagus and alleviates heartburn symptoms.
  • Gastric and duodenal ulcers: promotes ulcer healing by suppressing gastric acid production.
  • NSAID‑induced ulcer recurrence: prevents re‑formation of ulcers in patients taking non‑steroidal anti‑inflammatory drugs.
  • Zollinger‑Ellison syndrome: controls hyper‑secretion of gastric acid associated with gastrin‑producing tumors.

How It Works

  • Omeprazole sodium irreversibly binds to the H+/K+ ATPase enzyme (gastric proton pump) located on the luminal surface of parietal cells. By inhibiting this final step of acid secretion, it markedly reduces basal and stimulated gastric acid output, leading to an elevated gastric pH and providing a therapeutic environment for ulcer healing and symptom relief in acid‑related disorders.

Side Effects

Adverse reactions may occur with any medication and should be monitored by healthcare professionals.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Diarrhea: loose stools occurring intermittently.
  • Nausea: sensation of stomach upset.
  • Abdominal pain: discomfort in the upper abdomen.
  • Flatulence: increased intestinal gas.
  • Dizziness: transient light‑headed feeling.

Serious or Rare Side Effects

  • Severe allergic reaction: rash, itching, swelling, or difficulty breathing.
  • Clostridioides difficile infection: persistent watery diarrhea, abdominal cramping.
  • Low magnesium levels: muscle cramps, irregular heartbeat.
  • Liver enzyme elevation: abnormal liver function tests.
  • Bone fractures: increased risk with long‑term use.
  • Acute interstitial nephritis: kidney inflammation presenting with fever and urinary changes.

Precautions & Warnings

Before initiating therapy, consider patient‑specific factors and monitor for potential risks.

  • Renal impairment: adjust therapy and monitor renal function.
  • Hepatic disease: use with caution in patients with liver dysfunction.
  • Elderly patients: increased susceptibility to electrolyte disturbances.
  • Concomitant use of antiplatelet agents: monitor for bleeding risk.
  • Long‑term therapy: assess need for periodic evaluation of bone health and magnesium levels.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze.

Avoid Interactions

Omeprazol Zentiva may affect the pharmacokinetics of other medicines; interaction management is essential.

Major Interactions (Avoid)

  • Ketoconazole or itraconazole: reduced antifungal absorption.
  • Atazanavir: decreased antiviral efficacy.
  • Clopidogrel: diminished antiplatelet activity.
  • Warfarin: potential alteration of anticoagulant effect.
  • Methotrexate (high dose): increased toxicity risk.

Moderate Interactions (Monitor Closely)

  • Digoxin: possible increase in serum levels.
  • Diazepam: enhanced sedation.
  • Iron salts: decreased iron absorption.
  • Vitamin B12: potential reduction with prolonged use.
  • Calcium carbonate: reduced calcium uptake.

Frequently Asked Questions

Omeprazol Zentiva is indicated for the management of gastro‑esophageal reflux disease, healing of gastric and duodenal ulcers, prevention of ulcer recurrence in patients using NSAIDs, and control of acid hyper‑secretion in Zollinger‑Ellison syndrome. It works by reducing gastric acid production, which helps relieve symptoms and promote mucosal healing.

Omeprazole sodium acts by irreversibly inhibiting the H+/K+ ATPase enzyme, also known as the gastric proton pump, located on the secretory surface of parietal cells. This inhibition blocks the final step of acid secretion, leading to a sustained increase in gastric pH and reduction of both basal and stimulated gastric acid output.

The specific dose and infusion rate of Omeprazol Zentiva are determined by the prescribing clinician based on the patient’s condition, severity, and response to therapy. Healthcare professionals adjust the regimen according to clinical guidelines and individual patient factors.

Safety data for omeprazole sodium in pregnancy and lactation are limited. The drug should only be used if the potential benefit justifies any potential risk to the fetus or infant, and the decision must be made by the treating physician in consultation with the patient.

To place an order, submit an enquiry on the product page at gnhindia.com, providing the required quantity and your institutional details. GNH India supplies hospitals, pharmacies, and procurement teams worldwide, and will request trade or institutional credentials before responding with pricing, availability, shipping terms, and any necessary import documentation.

Omeprazol Zentiva belongs to the proton pump inhibitor class, which provides more potent and longer‑lasting acid suppression than H2‑receptor antagonists such as ranitidine. Compared with other PPIs, omeprazole has a well‑established efficacy profile and is available in an intravenous formulation for rapid onset in hospitalized patients.

Omeprazol Zentiva should be stored at 2‑8 °C in a refrigerator, protected from light. The solution must not be frozen or shaken vigorously. Keep the product in its original packaging to maintain stability until it is prepared for administration.

The medication is supplied as an intravenous solution and is administered by slow infusion into a vein, typically under the supervision of a healthcare professional. The infusion rate and duration are set by the prescribing clinician according to the therapeutic indication and patient response.

Serious adverse reactions may include severe allergic responses (anaphylaxis), Clostridioides difficile‑associated diarrhea, hypomagnesemia, liver enzyme elevations, acute interstitial nephritis, and increased risk of bone fractures with prolonged use. Patients should be monitored for these events, especially during long‑term therapy.

Patients with known hypersensitivity to omeprazole, other proton pump inhibitors, or any component of the formulation should avoid this product. Caution is also advised for individuals with severe liver disease, certain drug interactions, or those requiring high‑dose methotrexate, where alternative therapies may be preferred.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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