Product image of Omeprazole Aurobindo (Omeprazole) supplied by GNH India

Omeprazole Aurobindo

Active Ingredient:
Omeprazole
Origin:
EU

Omeprazole Aurobindo (Omeprazole)

Omeprazole, the active ingredient in Omeprazole Aurobindo, is a proton pump inhibitor presented as a tablet for oral use. It reduces gastric acid secretion and is employed in the treatment of acid‑related conditions such as gastro‑oesophageal reflux disease and peptic ulcers.

GNH India supplies Omeprazole Aurobindo as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable sourcing for regulated markets, including EU and other major jurisdictions globally.

Manufacturer / TM Owner

Aurobindo N.V.

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Indications & Clinical Uses

Omeprazole acts on the gastric proton pump to control acid secretion, making it useful for several acid‑related disorders.

  • Gastro‑oesophageal reflux disease (GERD): reduces reflux symptoms and promotes healing of esophageal irritation.
  • Peptic ulcer disease: facilitates ulcer healing by lowering gastric acidity.
  • Erosive oesophagitis: accelerates mucosal repair in acid‑induced esophageal damage.
  • Helicobacter pylori eradication (as part of combination therapy): enhances the effectiveness of antibiotics.
  • Zollinger‑Ellison syndrome: controls excessive gastric acid production in this rare endocrine disorder.

How It Works

  • Omeprazole selectively and irreversibly inhibits the H+/K+‑ATPase enzyme (the gastric proton pump) located on the secretory surface of parietal cells. By blocking this final step of acid production, it markedly reduces both basal and stimulated gastric acid secretion, thereby increasing gastric pH and allowing damaged mucosa to heal.

Side Effects

Omeprazole is generally well tolerated, but a range of adverse reactions have been reported.

Common Side Effects

  • Headache: mild to moderate intensity, often transient.
  • Diarrhea: loose stools that may resolve with continued therapy.
  • Abdominal pain: discomfort or cramping in the stomach region.
  • Nausea: feeling of unease or urge to vomit.
  • Flatulence: increased intestinal gas.
  • Constipation: reduced bowel movements.

Serious or Rare Side Effects

  • Severe allergic reaction (anaphylaxis): rash, swelling, difficulty breathing.
  • Clostridioides difficile infection: severe diarrhea with possible colitis.
  • Hypomagnesemia: low serum magnesium leading to muscle cramps or arrhythmia.
  • Elevated liver enzymes: potential hepatic injury.
  • Stevens‑Johnson syndrome: serious skin and mucous membrane disorder.
  • Interstitial nephritis: inflammation of kidney interstitium.

Precautions & Warnings

Before initiating therapy, consider the following safety measures.

  • Renal function assessment: adjust use in patients with severe impairment.
  • Elderly patients: monitor for increased sensitivity to side effects.
  • Long‑term use: evaluate necessity periodically to avoid unnecessary exposure.
  • Magnesium monitoring: check levels during prolonged treatment.
  • Concomitant medications: review for drugs that may require dose adjustment.
  • Store below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Omeprazole can affect the pharmacokinetics of several co‑administered medicines.

Major Interactions (Avoid)

  • Atazanavir (HIV protease inhibitor): markedly reduced absorption.
  • Nelfinavir (HIV protease inhibitor): decreased plasma concentrations.
  • Dasatinib (cancer therapy): reduced efficacy due to altered gastric pH.

Moderate Interactions (Monitor Closely)

  • Clopidogrel: reduced antiplatelet effect.
  • Warfarin: potential increase in INR.
  • Digoxin: possible rise in serum levels.
  • Methotrexate (high dose): decreased renal clearance.
  • Phenytoin: altered metabolism leading to variable levels.

Frequently Asked Questions

Omeprazole Aurobindo is indicated for the treatment of gastro‑oesophageal reflux disease, peptic ulcer disease, erosive oesophagitis, as part of Helicobacter pylori eradication regimens, and for controlling acid hypersecretion in Zollinger‑Ellison syndrome. It works by reducing gastric acid production, which helps heal mucosal damage and relieve symptoms.

Omeprazole inhibits the H+/K+‑ATPase enzyme, also known as the gastric proton pump, located on the secretory surface of parietal cells. This irreversible blockade stops the final step of acid secretion, leading to a sustained increase in gastric pH and allowing ulcerated or inflamed tissue to recover.

The appropriate dose of Omeprazole Aurobindo is determined by the prescribing healthcare professional based on the specific indication, patient age, renal function, and treatment duration. Dosage regimens may vary, and patients should follow the prescriber’s instructions without self‑adjusting the amount.

Omeprazole is classified as pregnancy category B in many jurisdictions, indicating no evidence of risk in animal studies but limited human data. It should be used during pregnancy or lactation only if clearly needed and after a risk‑benefit assessment by the prescriber. Breastfeeding mothers should consult their doctor.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, confirming trade or institutional credentials before providing pricing, availability, shipping details, and any necessary import documentation.

Omeprazole belongs to the same class as esomeprazole, lansoprazole, pantoprazole, and rabeprazole. All share a similar mechanism of inhibiting the gastric proton pump, but they differ in pharmacokinetic profiles, potency, and drug‑interaction potential. Choice of agent often depends on physician preference, patient response, and specific drug‑interaction considerations.

Omeprazole Aurobindo tablets should be stored at temperatures below 25 °C, in the original packaging to protect from moisture and light. Keep the product out of reach of children and avoid storing in humid environments such as bathrooms.

Omeprazole Aurobindo is taken orally, usually as a whole tablet swallowed with a glass of water. It is generally recommended to take the dose before a meal, often in the morning, unless the prescriber advises a different schedule based on the therapeutic goal.

Serious risks, though uncommon, include severe allergic reactions (anaphylaxis), Clostridioides difficile‑associated diarrhea, low magnesium levels, liver enzyme elevations, and rare skin conditions such as Stevens‑Johnson syndrome. Patients should seek immediate medical attention if they experience rash, persistent diarrhea, muscle cramps, or signs of liver dysfunction.

Omeprazole Aurobindo is contraindicated in individuals with known hypersensitivity to omeprazole or any component of the formulation. Caution is advised for patients with severe liver disease, those taking medications that require an acidic environment for absorption, and patients with certain genetic metabolic disorders. The prescriber will assess suitability.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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