Omeprazole Teva (Omeprazole)

Omeprazole is a proton pump inhibitor that acts on gastric acid secretion.

• Gastro‑esophageal reflux disease (GERD): provides symptomatic relief and promotes healing of esophageal irritation.
• Erosive esophagitis: accelerates mucosal healing and reduces recurrence.
• Peptic ulcer disease: promotes ulcer healing and prevents recurrence.
• Helicobacter pylori eradication (in combination therapy): enhances eradication rates when used with antibiotics.
• Zollinger‑Ellison syndrome: controls excessive gastric acid secretion.

• Omeprazole selectively and irreversibly inhibits the H+/K+‑ATPase enzyme (the gastric proton pump) located on the secretory surface of parietal cells, thereby blocking the final step of acid production and maintaining a higher gastric pH.

Omeprazole is generally well tolerated, but adverse reactions can occur.

Common Side Effects

• Headache: mild to moderate intensity.
• Abdominal pain: discomfort in the upper abdomen.
• Nausea: occasional feeling of queasiness.
• Diarrhea: loose stools, usually transient.
• Flatulence: increased intestinal gas.
• Constipation: reduced bowel movements.

Serious or Rare Side Effects

• Clostridioides difficile infection: severe colitis presenting with watery diarrhea.
• Severe allergic reactions: rash, itching, swelling, or anaphylaxis.
• Hepatic enzyme elevation: increased ALT/AST levels.
• Hypomagnesemia: low serum magnesium with possible muscle cramps or arrhythmias.

When prescribing Omeprazole, consider the following safety measures.

• Assess renal and hepatic function: adjust use in severe impairment.
• Monitor long‑term therapy: evaluate bone health and fracture risk.
• Avoid in known hypersensitivity: discontinue if allergic reaction occurs.
• Caution with concomitant warfarin: monitor INR closely.
• Use during pregnancy only if clearly needed: discuss risks with the prescriber.
• Store below 25°C: keep in the original pack, protect from moisture.

Omeprazole can affect the pharmacokinetics of several medicines.

Major Interactions (Avoid)

• Clopidogrel: reduced antiplatelet effect, may increase cardiovascular risk.
• Ketoconazole or itraconazole: decreased absorption due to higher gastric pH.
• CYP2C19 inhibitors (e.g., fluconazole): increased omeprazole plasma levels.

Moderate Interactions (Monitor Closely)

• Warfarin: potential alteration of INR, require closer monitoring.
• Digoxin: possible increase in serum concentration.
• Methotrexate (high dose): reduced renal clearance, monitor toxicity.
• HIV protease inhibitors (e.g., atazanavir): decreased efficacy, consider alternative therapy.