Product image of Omeprol (Omeprazole) supplied by GNH India

Omeprol

Active Ingredient:
Omeprazole
Origin:
EU

Omeprol (Omeprazole)

Omeprazole, the active ingredient in Omeprol, is a proton pump inhibitor presented as a / oral use. It reduces gastric acid secretion and is used to manage conditions such as gastro‑oesophageal reflux disease and peptic ulcer disease in adults and children.

GNH India supplies Omeprol as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Farmellas Enterprises Ltd

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Indications & Clinical Uses

Omeprazole is used to treat acid‑related disorders by decreasing stomach acidity.

  • Gastro‑oesophageal reflux disease (GERD): helps heal erosive esophagitis and relieve heartburn.
  • Peptic ulcer disease: promotes ulcer healing and reduces recurrence.
  • Zollinger‑Ellison syndrome: controls gastric acid hypersecretion.
  • Helicobacter pylori eradication regimens: used as part of combination therapy to improve eradication rates.
  • NSAID‑associated ulcer prophylaxis: lowers risk of ulcer formation in at‑risk patients.

How It Works

  • Omeprazole selectively inhibits the H+/K+‑ATPase enzyme (the gastric proton pump) located on the secretory surface of parietal cells. By binding covalently to the pump’s cysteine residues, it blocks the final step of acid production, leading to a sustained increase in gastric pH and reduced acid-mediated mucosal damage.

Side Effects

Omeprazole is generally well tolerated, but adverse reactions can occur.

Common Side Effects

  • Headache: mild and transient.
  • Diarrhea: usually self‑limiting.
  • Nausea: occasional mild upset.
  • Abdominal pain: mild cramping.
  • Flatulence: excess gas.
  • Constipation: occasional bowel changes.

Serious or Rare Side Effects

  • Clostridioides difficile infection: severe colitis risk.
  • Hypomagnesemia: low magnesium levels with prolonged use.
  • Vitamin B12 deficiency: reduced absorption over time.
  • Acute interstitial nephritis: kidney inflammation.
  • Stevens‑Johnson syndrome: rare severe skin reaction.
  • Fracture risk: possible reduced bone density with long‑term therapy.

Precautions & Warnings

When using Omeprazole, consider the following precautions:

  • Assess renal function: dose adjustment may be needed in severe impairment.
  • Monitor magnesium levels: long‑term therapy can lower serum magnesium.
  • Evaluate bone health: prolonged use may affect calcium absorption.
  • Review concomitant medications: potential for altered drug absorption.
  • Pregnancy and lactation: use only if clearly needed after risk‑benefit assessment.
  • Store at below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Omeprazole can affect the plasma concentrations of several co‑administered drugs.

Major Interactions (Avoid)

  • Clopidogrel: reduced antiplatelet effect, consider alternative therapy.
  • Atazanavir: markedly decreased absorption, contraindicated.
  • Dasatinib: reduced exposure, may require dose adjustment.

Moderate Interactions (Monitor Closely)

  • Warfarin: potential increase in INR, monitor coagulation parameters.
  • Phenytoin: decreased serum levels, monitor seizure control.
  • Methotrexate: increased toxicity risk, especially at high doses.
  • Digoxin: modest increase in serum concentration, observe for signs of toxicity.

Frequently Asked Questions

Omeprol contains omeprazole, a proton pump inhibitor that reduces stomach acid. It is prescribed for conditions such as gastro‑oesophageal reflux disease, peptic ulcer disease, Zollinger‑Ellison syndrome, and as part of Helicobacter pylori eradication regimens. The medication helps heal acid‑related damage to the gastrointestinal lining and prevents recurrence of ulcers.

Omeprazole works by selectively and irreversibly inhibiting the H+/K+‑ATPase enzyme, also known as the gastric proton pump, in the parietal cells of the stomach. This inhibition blocks the final step of gastric acid secretion, leading to a sustained increase in gastric pH and reduced acidity that allows damaged tissue to heal.

The appropriate dose of Omeprol is determined by a qualified prescriber based on the patient’s specific condition, age, and response to therapy. Healthcare professionals set the dosage regimen and duration according to clinical guidelines and individual therapeutic needs.

Omeprazole is classified as pregnancy category B in many regions, indicating no evidence of risk in animal studies but limited human data. It should be used during pregnancy or lactation only if clearly needed after a careful risk‑benefit assessment by the treating physician.

To order Omeprol, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request trade or institutional credentials before providing pricing, availability, shipping details and any necessary import documentation.

Omeprol (omeprazole) belongs to the proton pump inhibitor class, which provides more potent and longer‑lasting acid suppression than H2‑receptor antagonists such as ranitidine. Compared with newer PPIs like esomeprazole, omeprazole offers similar efficacy at a generally lower cost, though individual response may vary.

Omeprol should be stored at temperatures below 25 °C, in its original packaging, protected from moisture and direct sunlight. Maintaining these conditions helps preserve the tablet’s stability and potency throughout its shelf life.

Omeprol is taken orally, usually as a tablet swallowed whole with water. It is commonly recommended to take the dose before a meal, often in the morning, but patients should follow the prescribing clinician’s instructions regarding timing and food intake.

Serious risks, though rare, include Clostridioides difficile‑associated colitis, severe hypersensitivity reactions such as Stevens‑Johnson syndrome, acute interstitial nephritis, and long‑term complications like hypomagnesemia, vitamin B12 deficiency and increased fracture risk. Patients should report any severe or persistent symptoms to their healthcare provider promptly.

Omeprol is contraindicated in individuals with known hypersensitivity to omeprazole or other proton pump inhibitors. Caution is also advised for patients with severe liver disease, those taking certain interacting medications such as clopidogrel, and pregnant or breastfeeding women unless the benefit outweighs the risk.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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