Product image of Omidria (Ketorolac, Phenylephrine) supplied by GNH India

Omidria

Active Ingredient:
Ketorolac, Phenylephrine
Origin:
EU

Omidria (Ketorolac, Phenylephrine)

Ketorolac tromethamine, the active ingredient in Omidria, is a nonsteroidal anti‑inflammatory drug (NSAID) presented as a 0.3 mg/mL ophthalmic solution for intraocular use. It, combined with phenylephrine hydrochloride, helps maintain pupil dilation during intraocular surgery and reduces postoperative ocular pain.

GNH India supplies Omidria as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres and ophthalmic clinics worldwide.

Manufacturer / TM Owner

Rayner Pharmaceuticals

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Indications & Clinical Uses

Omidria, containing ketorolac and phenylephrine, is indicated for ophthalmic procedures involving intraocular surgery.

  • Intraocular surgery: maintains pupil dilation throughout the procedure.
  • Post‑operative period: reduces ocular pain after surgery.
  • Ophthalmic inflammation: provides anti‑inflammatory effect during and after surgery.

How It Works

  • Ketorolac tromethamine inhibits cyclooxygenase enzymes, decreasing prostaglandin synthesis and thereby reducing inflammation and pain. Phenylephrine hydrochloride activates alpha‑1 adrenergic receptors on the iris dilator muscle, causing contraction and resulting in pupil dilation. The combined actions provide both anti‑inflammatory relief and sustained mydriasis during ocular procedures.

Side Effects

Omidria may cause ocular and systemic reactions after administration.

Common Side Effects

  • Eye irritation: mild burning or stinging on instillation.
  • Redness: conjunctival hyperemia.
  • Blurred vision: temporary visual disturbance.
  • Increased intra‑ocular pressure: transient rise after dosing.
  • Dry eye sensation.
  • Headache.

Serious or Rare Side Effects

  • Severe allergic reaction: anaphylaxis, angioedema.
  • Significant rise in intra‑ocular pressure leading to optic nerve damage.
  • Corneal edema or ulceration.
  • Endophthalmitis (intra‑ocular infection).
  • Systemic hypertension or tachycardia.
  • Vision loss.

Precautions & Warnings

Before using Omidria, clinicians should consider patient‑specific factors and monitor for adverse events.

  • Assess ocular history: avoid in patients with narrow‑angle glaucoma.
  • Monitor intra‑ocular pressure: phenylephrine may increase pressure.
  • Check for hypersensitivity: do not use if known allergy to NSAIDs or phenylephrine.
  • Use with caution in cardiovascular disease: phenylephrine can raise systemic blood pressure.
  • Pregnancy and lactation: safety not established; use only if benefits outweigh risks.
  • Store at room temperature: keep in the original container, protect from light and moisture.

Avoid Interactions

Omidria can interact with systemic and ocular agents; appropriate monitoring is advised.

Major Interactions (Avoid)

  • Systemic NSAIDs: increased risk of bleeding.
  • MAO inhibitors: may potentiate hypertensive response to phenylephrine.
  • Other sympathomimetic agents: additive vasoconstriction.

Moderate Interactions (Monitor Closely):\n- Beta‑blockers: may blunt systemic cardiovascular effects.

  • Antihypertensives: monitor blood pressure for additive effects.
  • Other ocular mydriatics: cumulative pupil dilation may be excessive.

Frequently Asked Questions

Omidria is an ophthalmic solution that combines ketorolac, an NSAID, with phenylephrine, an alpha‑1 agonist. It is used to maintain pupil dilation during intraocular surgery and to reduce postoperative ocular pain, providing both anti‑inflammatory and mydriatic effects.

Ketorolac inhibits cyclooxygenase enzymes, which reduces the synthesis of prostaglandins—key mediators of inflammation and pain. By lowering prostaglandin levels in ocular tissues, ketorolac helps control inflammation and discomfort associated with eye surgery.

The dosing regimen for Omidria is determined by the prescribing ophthalmologist based on the specific surgical procedure and patient needs. The product is supplied as a ready‑to‑use ophthalmic solution, and the prescriber sets the volume and timing of each intra‑ocular instillation.

Safety of Omidria in pregnancy and lactation has not been established. It should be used only if the potential benefit justifies any potential risk to the fetus or infant, and the decision should be made by the treating physician.

To order Omidria, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Unlike single‑agent mydriatics, Omidria combines a potent NSAID with phenylephrine, offering both anti‑inflammatory relief and sustained pupil dilation in one formulation. This dual action can simplify peri‑operative regimens compared with using separate NSAID drops and mydriatic agents.

Store Omidria at room temperature, preferably below 25 °C. Keep the vial in its original packaging, protect it from direct light and moisture, and avoid freezing. Do not refrigerate unless specifically instructed by the supplier.

Omidria is administered as an intra‑ocular (ophthalmic) solution. The prescribed volume is instilled directly into the eye, typically by the surgeon at the start of the procedure and, if required, during the postoperative period as directed.

Serious risks include severe allergic reactions such as anaphylaxis, significant increases in intra‑ocular pressure that could threaten optic nerve health, corneal complications, and systemic hypertension from phenylephrine. Immediate medical attention is required if any of these occur.

Patients with known hypersensitivity to ketorolac, phenylephrine, or any component of the formulation should not use Omidria. It is also contraindicated in individuals with narrow‑angle glaucoma, uncontrolled hypertension, or those taking MAO inhibitors without careful medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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