Omisson (Dienogest, Ethinylestradiol)

Omisson combines dien­shest and ethinylestradiol to treat estrogen‑dependent conditions within the hormonal contraceptive pathway.

• Contraception: provides reliable, reversible birth control for women seeking oral hormonal contraception.
• Menstrual disorders: helps regulate irregular cycles and reduce heavy menstrual bleeding.
• Endometriosis‑related pain: alleviates pelvic pain associated with endometriosis.
• Acne vulgaris: improves skin lesions by modulating androgen activity.
• Polycystic ovary syndrome (PCOS) symptoms: assists in cycle regulation and androgen reduction.

• Dienogest is a progestogenic agent that binds to progesterone receptors, exerting anti‑ovulatory and endometrial‑stabilising effects, while ethinylestradiol activates estrogen receptors to provide cycle control. The combination suppresses the hypothalamic‑pituitary‑gonadal axis, reducing follicular development and stabilising the endometrium, which underlies its contraceptive and therapeutic actions.

Adverse reactions may vary in frequency and severity.

Common Side Effects

• Nausea: mild to moderate stomach upset.
• Headache: tension‑type or migraine‑like pain.
• Breast tenderness: transient swelling or discomfort.
• Weight gain: modest increase in body weight.
• Mood changes: irritability or emotional lability.
• Spotting between periods: light vaginal bleeding.

Serious or Rare Side Effects

• Venous thromboembolism: deep‑vein clot or pulmonary embolism.
• Arterial thrombosis: stroke or myocardial infarction.
• Severe hypertension: sudden rise in blood pressure.
• Liver dysfunction: abnormal liver enzymes or jaundice.
• Allergic reactions: rash, itching, swelling, or anaphylaxis.
• Visual disturbances: blurred vision or retinal vein occlusion.

Before starting Omisson, consider the following safety measures:

• Smoking status: avoid use if you smoke >15 cigarettes/day and are over 35 years old.
• Cardiovascular risk: assess history of hypertension, thrombosis, or heart disease.
• Liver function: evaluate hepatic health prior to therapy.
• Migraine history: caution if you have migraine with aura.
• Pregnancy and lactation: discontinue if pregnant or planning pregnancy; not recommended while breastfeeding.
• Store at below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Omisson may interact with several medicines, requiring clinical awareness.

Major Interactions (Avoid)

• Anticoagulants: may reduce effectiveness of warfarin, requiring INR monitoring.
• Enzyme inducers: carbamazepine, phenytoin, rifampicin can lower hormonal levels, decreasing efficacy.
• Antifungal azoles: ketoconazole may increase plasma concentrations, raising side‑effect risk.

Moderate Interactions (Monitor Closely)

• Antidepressants: SSRIs such as fluoxetine may increase bleeding risk.
• Antibiotics: broad‑spectrum agents like tetracycline may slightly reduce contraceptive reliability.
• Herbal supplements: St. John’s wort may diminish hormonal exposure.