Product image of Omniscan (Gadodiamide) supplied by GNH India

Omniscan

Active Ingredient:
Gadodiamide
Origin:
EU

Omniscan (Gadodiamide)

Gadodiamide, the active ingredient in Omniscan, is a gadolinium‑based contrast agent presented as an injectable solution for intravenous use. It enhances magnetic resonance imaging of the brain, spine, cardiovascular system and other body regions in both adult and pediatric patients.

GNH India supplies Omniscan as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, imaging centres and clinics worldwide. The product complies with EU regulatory standards and is distributed under strict quality assurance protocols. It is intended for use by qualified radiology professionals in diagnostic imaging procedures.

Manufacturer / TM Owner

Ge Healthcare As

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Indications & Clinical Uses

  • Omniscan (gadodiamide) is used as a gadolinium‑based contrast medium to improve magnetic resonance imaging across several clinical areas.
  • Central nervous system MRI: improves detection and delineation of lesions, tumors and vascular abnormalities.
  • Magnetic resonance angiography (MRA): enhances visualization of arterial and venous structures.
  • Abdominal and pelvic MRI: provides superior tissue contrast for assessment of tumors and inflammatory conditions.
  • Cardiac MRI: assists in evaluating myocardial perfusion and scar tissue.

How It Works

  • Gadodiamide is a chelated gadolinium complex that shortens the T1 relaxation time of nearby water protons. After intravenous injection, it distributes into the extracellular space and transiently alters magnetic properties, producing increased signal intensity on T1‑weighted MRI sequences. This enhancement allows clearer differentiation of vascular and tissue structures during diagnostic imaging.

Side Effects

Gadodiamide may be associated with a range of adverse reactions following intravenous administration.

Common Side Effects

  • Nausea: mild to moderate feeling of sickness.
  • Headache: transient discomfort after injection.
  • Injection site pain or warmth: brief sensation at the infusion site.
  • Dizziness: temporary light‑headedness.

Serious or Rare Side Effects

  • Nephrogenic systemic fibrosis (NSF): a rare fibrotic disorder in patients with severe renal impairment.
  • Severe allergic reactions: including anaphylaxis, bronchospasm and urticaria.
  • Gadolinium retention: long‑term deposition in brain or bone tissue, of uncertain clinical significance.
  • Renal failure exacerbation: worsening of pre‑existing kidney dysfunction.

Precautions & Warnings

  • Before administering Omniscan, clinicians should observe several safety measures.
  • Renal function assessment: evaluate glomerular filtration rate before administration.
  • History of contrast reactions: screen patients for prior hypersensitivity to gadolinium agents.
  • Pregnancy: use only when essential, after risk‑benefit analysis.
  • Breastfeeding: consider potential exposure and discuss with healthcare provider.
  • Concurrent nephrotoxic drugs: monitor renal status closely.
  • Store at ambient temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Gadodiamide can interact with other medicines or agents that affect renal function or cumulative gadolinium exposure.

Major Interactions (Avoid)

  • Severe renal impairment drugs (e.g., high‑dose NSAIDs): increase risk of NSF.
  • Concurrent use of other gadolinium agents: may lead to cumulative gadolinium load.
  • Iodinated contrast media: combined renal stress may worsen kidney function.

Moderate Interactions (Monitor Closely)

  • Diuretics: monitor fluid and electrolyte balance during imaging.
  • Metformin: assess renal function and consider temporary discontinuation per guidelines.

Frequently Asked Questions

Omniscan is a gadolinium‑based contrast medium used to enhance magnetic resonance imaging (MRI) studies. It improves the visibility of blood vessels, organs and pathological lesions, aiding radiologists in diagnosing conditions of the brain, spine, heart, abdomen and musculoskeletal system.

Gadodiamide is a chelated gadolinium complex that shortens the T1 relaxation time of nearby water protons. When injected intravenously, it distributes into the extracellular space and temporarily increases signal intensity on T1‑weighted MRI sequences, providing clearer contrast between normal and abnormal tissues.

The dose of Omniscan is determined by the prescribing physician based on the specific imaging protocol, patient weight, age and renal function. Healthcare professionals calculate the appropriate volume to achieve the recommended gadolinium concentration for the intended MRI examination.

Omniscan should be used in pregnancy only if the potential diagnostic benefit outweighs the possible risk to the fetus. Limited data are available for breastfeeding mothers; therefore, clinicians usually advise caution and may recommend temporary cessation of breastfeeding or monitoring the infant, depending on the clinical situation.

To order Omniscan, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if required) and necessary import documentation.

Omniscan (gadodiamide) is a non‑ionic, linear gadolinium chelate. Compared with macrocyclic agents, it has a slightly higher propensity for gadolinium release in patients with severe renal impairment, which may increase the risk of nephrogenic systemic fibrosis. However, it provides comparable image enhancement for most routine MRI examinations.

Omniscan should be stored at ambient temperature, protected from light and moisture, and kept in its original packaging until use. The product is supplied in a sterile vial for single‑use intravenous injection; it must not be frozen or shaken, and any unused portion should be discarded according to local regulations.

Omniscan is administered by a qualified healthcare professional as an intravenous injection, typically through a peripheral or central vein. The volume is injected at a rate recommended by the imaging protocol, often followed by a saline flush to ensure complete delivery of the contrast agent into the circulation.

The most serious risks include nephrogenic systemic fibrosis (NSF) in patients with severe renal dysfunction, severe allergic reactions such as anaphylaxis, and potential gadolinium retention in the brain or bone. Clinicians should assess renal function before use and monitor patients closely for any signs of hypersensitivity.

Omniscan is contraindicated in patients with known hypersensitivity to gadodiamide or any component of the formulation. It should also be avoided in individuals with severe renal impairment (eGFR <30 mL/min/1.73 m²) unless the diagnostic benefit justifies the risk, and in patients with a history of NSF.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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