Product image of Omzar (Esomeprazole Magnesium Dihydrate) supplied by GNH India

Omzar

Active Ingredient:
Esomeprazole Magnesium Dihydrate
Origin:
EU

Omzar (Esomeprazole Magnesium Dihydrate)

Esomeprazole Magnesium Dihydrate, the active ingredient in Omzar, is a proton pump inhibitor (PPI) presented as a tablet for oral use. It reduces stomach acid production and is used to treat acid‑related gastrointestinal conditions in adults and adolescents.
GNH India supplies Omzar as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Maddox Pharma Swiss B.V.

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Indications & Clinical Uses

Omzar is a proton pump inhibitor that acts on the gastric acid secretion pathway. It is indicated for several acid‑related disorders:

  • Gastro‑esophageal reflux disease (GERD): provides relief of heartburn and promotes healing of erosive esophagitis.
  • Peptic ulcer disease: supports ulcer healing and reduces recurrence risk.
  • Zollinger‑Ellison syndrome: controls excessive gastric acid secretion associated with the condition.

How It Works

  • Esomeprazole magnesium dihydrate selectively inhibits the H+/K+‑ATPase enzyme (the gastric proton pump) on the parietal cell surface, blocking the final step of acid secretion. By binding irreversibly to the pump, it markedly lowers gastric acidity, allowing mucosal healing and symptom relief.

Side Effects

Adverse reactions to esomeprazole may vary in frequency and severity.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Diarrhea: usually self‑limiting.
  • Nausea: occasional and transient.
  • Abdominal pain: mild discomfort.
  • Flatulence: excess gas.
  • Constipation: occasional bowel habit change.

Serious or Rare Side Effects

  • Severe allergic reaction: rash, itching, swelling, or difficulty breathing.
  • Clostridioides difficile infection: persistent watery diarrhea.
  • Low magnesium levels: muscle cramps, irregular heartbeat.
  • Bone fracture risk: especially with long‑term use.
  • Liver enzyme elevation: signs of hepatic dysfunction.
  • Acute interstitial nephritis: kidney inflammation presenting with fever and rash.

Precautions & Warnings

When prescribing Omzar, consider the following precautions:

  • Assess renal function: dose adjustment may be needed in severe impairment.
  • Monitor magnesium levels: prolonged therapy can cause hypomagnesemia.
  • Evaluate fracture risk: long‑term use may affect bone density.
  • Review concomitant medications: potential for altered absorption of drugs requiring acidic pH.
  • Pregnancy and lactation: use only if clearly needed after risk‑benefit assessment.
  • Store at ambient temperature: keep below 25°C, retain in original packaging and protect from moisture.

Avoid Interactions

Esomeprazole may interact with several medicines; interactions are grouped by clinical significance.

Major Interactions (Avoid)

  • Clopidogrel: reduced antiplatelet effect, may increase cardiovascular event risk.
  • Atazanavir and other protease inhibitors: markedly decreased antiviral exposure.
  • Methotrexate (high dose): increased serum concentrations, risk of toxicity.

Moderate Interactions (Monitor Closely)

  • Warfarin: potential increase in INR, monitor coagulation parameters.
  • Digoxin: higher serum levels may occur, check therapeutic range.
  • Diazepam: increased sedation, adjust dose if necessary.

Frequently Asked Questions

Omzar contains esomeprazole, a proton pump inhibitor that is prescribed for acid‑related gastrointestinal disorders such as gastro‑oesophageal reflux disease, peptic ulcer disease and Zollinger‑Ellison syndrome. It works by reducing stomach acid, helping to relieve symptoms and promote healing of the gastrointestinal lining.

Esomeprazole selectively and irreversibly inhibits the gastric H+/K+‑ATPase (proton pump) on parietal cells, blocking the final step of acid secretion. This suppression of gastric acid creates a less acidic environment, which alleviates symptoms and allows damaged mucosa to heal.

The specific dose of Omzar is determined by the prescribing clinician based on the patient’s condition, severity, and response to therapy. Healthcare professionals set the appropriate strength and dosing schedule according to current clinical guidelines.

Omzar should be used in pregnancy or while breastfeeding only when clearly needed and after a careful risk‑benefit assessment by the prescriber. Limited data suggest it is generally considered low risk, but clinicians should evaluate individual circumstances before prescribing.

To order Omzar, submit an enquiry on the product page at gnhindia.com, providing the required quantity and your institutional details. GNH India works with hospitals, pharmacies and procurement teams worldwide, confirming trade or institutional credentials before responding with pricing, availability, shipping terms and any necessary import documentation.

Omzar (esomeprazole) is the S‑enantiomer of omeprazole, offering more consistent acid suppression and a slightly longer duration of action compared with racemic PPIs. Clinical efficacy is comparable to other PPIs, but some patients may experience better symptom control or fewer drug‑interaction concerns with esomeprazole.

Omzar tablets should be stored at ambient temperature, below 25 °C, in their original packaging. Protect the product from moisture and direct sunlight to maintain stability throughout its shelf life.

Omzar is taken orally, usually as a whole tablet with water. It can be taken with or without food, but consistent timing each day helps maintain steady acid control. Patients should follow the prescriber’s instructions regarding timing relative to meals.

Serious risks, though uncommon, include severe allergic reactions, Clostridioides difficile‑associated diarrhea, low magnesium levels, increased fracture risk with long‑term use, and rare cases of liver enzyme elevation or acute interstitial nephritis. Patients should report any unusual symptoms promptly.

Omzar is contraindicated in individuals with known hypersensitivity to esomeprazole, other PPIs, or any component of the formulation. Caution is also advised for patients with severe liver disease, those taking interacting medications such as clopidogrel, and patients with a history of fractures or low magnesium levels.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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