Oncotice (Bacillus Calmette-Guérin (Bcg), Tice)

Oncotice is a live‑attenuated bacterial immunotherapy used within the uro‑urological pathway.

• Non‑muscle‑invasive bladder cancer: reduces recurrence and progression after tumour resection.
• Carcinoma in situ of the bladder: induces local immune response to eradicate malignant cells.
• High‑risk papillary tumours: provides adjuvant therapy to lower the chance of disease recurrence.

• Oncotice contains live‑attenuated Mycobacterium bovis (BCG) that, when instilled into the bladder, is internalised by urothelial and antigen‑presenting cells. This triggers a Th1‑dominant immune response, releasing cytokines such as IFN‑γ and TNIL  and recruiting immune effector  cells to attack  the tumour‑associated  antigens.

Oncotice may elicit a range of local and systemic reactions following intravesical administration.

Common Side Effects

• Mild urinary irritation: burning  or  pain  during  void  or  frequency.
• Low‑grade fever  and  chills  within  24  hours.
• Hematuria  or  blood  in  urine  that  resolves  spontaneously.
• Dysuria  or  pain  during  micturition.
• Transient fatigue  or  malaise  after  instillation.

Serious or Rare Side Effects

• Systemic BCG infection (disseminated mycobacterial disease).
• Severe allergic reaction or anaphylaxis.
• Persistent high‑grade fever lasting  >  48  hours.
• Acute renal  injury  or  obstructive  uropathy  due  to  edema  of  the  prostate  or  bladder neck.
• Sepsis sepsis  of  the  urinary  tract  or  bloodstream  infection  with  BC  ​  .

Oncotice requires careful clinical oversight during treatment.

• Assess  for  active  tuberculosis  or  latent  TB  infection  before  administration.
• Evaluate  immune  status  and  avoid  use  in  severely  immunocompromised  patients  (e.g., HIV  with  CD4  <  200).
• Monitor  renal  function  and  urinary  tract  obstruction  before  each  instillation.
• Conduct  cystoscopic  evaluation  prior  to  each  treatment  session  ​  .
• Store at  2‑                    """"  "  " " " " "  ""  ""  "" "  "  "