Product image of Ondansetrón B. Braun (Ondansetron) supplied by GNH India

Ondansetrón B. Braun

Active Ingredient:
Ondansetron
Origin:
EU

Ondansetrón B. Braun (Ondansetron)

Ondansetron, the active ingredient in Ondansetrón B. Braun, is a serotonin 5‑HT3 receptor antagonist presented as a tablet for oral use. It is used to prevent nausea and vomiting associated with chemotherapy, radiotherapy and postoperative recovery in adult and paediatric patients.

GNH India supplies Ondansetrón B. Braun as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres and pharmacies worldwide.

Manufacturer / TM Owner

B.Braun Melsungen Ag

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Indications & Clinical Uses

Ondansetron is employed across several clinical pathways that involve emesis control.

  • Chemotherapy‑induced nausea and vomiting (CINV): helps reduce the frequency and severity of nausea and vomiting in patients receiving cytotoxic chemotherapy.
  • Radiotherapy‑induced nausea and vomiting (RINV): provides prophylaxis and treatment of nausea and vomiting caused by radiation therapy.
  • Post‑operative nausea and vomiting (PONV): reduces the incidence of nausea and vomiting after surgical procedures.
  • Hyperemesis gravidarum (severe morning sickness): used off‑label in some regions to control persistent vomiting during pregnancy.

How It Works

  • Ondansetron selectively blocks serotonin (5‑HT3) receptors located on vagal afferent nerves in the gastrointestinal tract and in the chemoreceptor trigger zone of the brain. By inhibiting this receptor, the drug prevents the initiation of the vomiting reflex triggered by chemotherapeutic agents, radiation, or surgical stress.

Side Effects

Common Side Effects

  • Headache: mild to moderate intensity.
  • Constipation: reduced bowel movements.
  • Diarrhoea: loose stools, usually transient.
  • Fatigue: feeling of tiredness.
  • Dizziness: light‑headed sensation.
  • Injection site pain (if administered intravenously).

Serious or Rare Side Effects

  • Cardiac arrhythmia: QT‑interval prolongation, especially with high intravenous doses.
  • Severe hypersensitivity: rash, itching, swelling, or anaphylaxis.
  • Serotonin syndrome: rare when combined with other serotonergic agents.
  • Hepatic dysfunction: elevated liver enzymes in susceptible individuals.

Precautions & Warnings

When using Ondansetron, consider the following safety measures:

  • Cardiac monitoring: assess QT interval in patients with known cardiac disease or electrolyte imbalance.
  • Drug interactions: review concomitant medications that may prolong QT interval.
  • Renal impairment: adjust dosing in severe renal dysfunction.
  • Hepatic impairment: use caution in patients with liver disease.
  • Pregnancy and lactation: weigh benefits against potential risks; use only if clearly needed.
  • Store at ambient temperature: keep below 25 °C, in original packaging, protected from moisture and light.

Avoid Interactions

Ondansetron may interact with several medicines that affect cardiac rhythm or serotonin pathways.

Major Interactions (Avoid)

  • Amiodarone: additive QT‑prolongation risk.
  • Certain anti‑arrhythmics (e.g., sotalol, quinidine): may cause dangerous cardiac rhythm changes.
  • Other serotonergic agents (e.g., tramadol, linezolide): increase risk of serotonin syndrome.

Moderate Interactions (Monitor Closely)

  • Antifungal azoles (ketoconazole, fluconazole): can raise ondansetron plasma levels.
  • Macrolide antibiotics (erythromycin, clarithromycin): may modestly prolong QT interval.
  • Certain antipsychotics (haloperidol, ziprasidone): require ECG monitoring.

Frequently Asked Questions

Ondansetrón B. Braun contains ondansetron, a medication that is primarily used to prevent and treat nausea and vomiting caused by chemotherapy, radiotherapy, and surgery. It is also employed in some settings for severe pregnancy‑related vomiting when other options are unsuitable.

Ondansetron works by selectively blocking serotonin 5‑HT3 receptors in the gastrointestinal tract and the brain’s chemoreceptor trigger zone. This inhibition stops the signal cascade that normally triggers the vomiting reflex in response to chemotherapy, radiation or surgical stress.

The exact dose and dosing schedule are determined by the prescribing clinician based on the patient’s age, weight, the type of emetogenic stimulus and other clinical factors. Healthcare professionals follow local prescribing guidelines to set the appropriate regimen.

Ondansetron is classified as Pregnancy Category B in many regions, indicating no proven risk in animal studies but limited human data. It should be used only when the potential benefit justifies any possible risk to the fetus, and breastfeeding mothers should consult a physician before use.

To place an order, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Ondansetron belongs to the 5‑HT3 antagonist class, offering rapid onset and effective control of both acute and delayed nausea. Compared with dopamine antagonists such as metoclopramide, ondansetron has a lower risk of extrapyramidal side effects and is generally better tolerated for chemotherapy‑induced nausea.

Store the tablets at ambient temperature, preferably below 25 °C. Keep them in the original container, protect from moisture and direct light, and ensure the packaging remains sealed until use.

The product is supplied as oral tablets that are swallowed whole with water. In a clinical setting, an intravenous formulation may also be used, administered by a qualified healthcare professional according to institutional protocols.

The most serious risks include QT‑interval prolongation leading to cardiac arrhythmias, severe allergic reactions such as anaphylaxis, and, rarely, serotonin syndrome when combined with other serotonergic agents. Patients should be monitored for cardiac symptoms and allergic signs.

Ondansetron should be avoided in patients with known hypersensitivity to the drug or any 5‑HT3 antagonist, and in individuals with a history of significant QT prolongation or uncontrolled electrolyte disturbances unless closely monitored.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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