Product image of One-Alpha* (Alfacalcidol) supplied by GNH India

One-Alpha*

Active Ingredient:
Alfacalcidol
Origin:
EU

One-Alpha* (Alfacalcidol)

Alfacalcidol, the active ingredient in One-Alpha*, is a vitamin D analog presented as a oral formulation for oral use. It treats hypocalcemia, renal osteodystrophy, secondary hyperparathyroidism and osteoporosis in patients requiring calcium metabolism regulation.

GNH India supplies One-Alpha* as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Neon Healthcare Limited

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Indications & Clinical Uses

One-Alpha* is used to manage disorders of calcium and phosphate metabolism that arise from renal or bone disease pathways.

  • Hypocalcemia: helps restore normal calcium levels in the blood.
  • Renal osteodystrophy: improves bone mineralization in patients with chronic kidney disease.
  • Secondary hyperparathyroidism: reduces excess parathyroid hormone production.
  • Osteoporosis: supports bone density maintenance and reduces fracture risk.

How It Works

  • Alfacalcidol is converted in the liver to calcitriol (1,25‑dihydroxyvitamin D3), the active form of vitamin D. The metabolite binds to vitamin D receptors in intestinal cells, enhancing calcium and phosphate absorption and modulating bone remodeling processes.

Side Effects

Adverse reactions may range from mild to severe and should be monitored during therapy.

Common Side Effects

  • Nausea: mild stomach upset reported in some patients.
  • Hypercalcemia: elevated blood calcium levels causing fatigue or weakness.
  • Hyperphosphatemia: increased phosphate levels, potentially leading muscle cramps.
  • Headache: occasional mild headache.
  • Gastrointestinal discomfort: abdominal pain or dyspepsia.

Serious or Rare Side Effects

  • Nephrolithiasis: kidney stone formation.
  • Severe hypercalcemia: can cause cardiac arrhythmias.
  • Hypervitaminosis D: toxicity leading to calcification of soft tissues.
  • Allergic reactions: rash, itching, or anaphylaxis.
  • Metabolic bone pain: unexplained bone pain despite therapy.

Precautions & Warnings

Before initiating therapy, clinicians should evaluate patient-specific factors and monitor relevant laboratory values.

  • Renal function: assess creatinine clearance before use.
  • Serum calcium: check baseline and periodically during treatment.
  • Serum phosphate: monitor to avoid hyperphosphatemia.
  • Concomitant vitamin D: avoid excessive combined dosing.
  • Pregnancy and lactation: use only if clearly needed.
  • Store at ambient temperature: keep in original packaging, protect from moisture and light.

Avoid Interactions

Alfacalcidol may interact with several medicines that affect calcium balance or vitamin D metabolism.

Major Interactions (Avoid)

  • Thiazide diuretics: increase risk of hypercalcemia.
  • Calcium supplements: additive effect on serum calcium.
  • Vitamin D analogues: cumulative toxicity risk.

Moderate Interactions (Monitor Closely)

  • Anticonvulsants (e.g., phenobarbital): may reduce alfacalcidol effectiveness.
  • Corticosteroids: can impair vitamin D metabolism.
  • Bisphosphonates: may alter bone turnover dynamics.

Frequently Asked Questions

One-Alpha* contains alfacalcidol, a vitamin D analog that is prescribed to correct low blood calcium levels and to manage bone‑related conditions such as renal osteodystrophy, secondary hyperparathyroidism and osteoporosis.

Alfacalcidol is a pro‑drug that the liver converts to calcitriol, the active form of vitamin D. Calcitriol binds to vitamin D receptors in the intestine, increasing absorption of calcium and phosphate and influencing bone remodeling.

The dose of One-Alpha* is individualized by the prescribing clinician based on the patient’s calcium, phosphate, and renal function results. Dosage regimens are not standardized and should follow the prescriber’s instructions.

Safety data are limited; the product should only be used during pregnancy or lactation when the potential benefit outweighs any possible risk, and under close medical supervision.

To order, submit an enquiry on the One-Alpha* product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and necessary import documentation.

Alfacalcidol is converted to active vitamin D in the liver, whereas some alternatives such as calcitriol are already active and may require different monitoring. Choice of agent depends on the patient’s liver function, dosing convenience and clinician preference.

Store One-Alpha* at ambient temperature, below 25 °C, in the original container, protected from moisture and direct light to maintain potency.

One-Alpha* is taken orally, usually with or without food, as directed by the prescribing healthcare professional.

Serious risks include severe hypercalcemia, kidney stone formation, and vitamin D toxicity, which can lead to soft‑tissue calcification and cardiac arrhythmias. Prompt monitoring of calcium and phosphate levels is essential.

Patients with known hypersensitivity to alfacalcidol or other vitamin D analogues, uncontrolled hypercalcemia, or severe renal impairment should avoid using One-Alpha* unless specifically directed by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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