Onisid (Tioconazole)

Tioplan is a broad‑spectrum imidazole that acts on dermatophyte and yeast infections of the skin.

• Athlete’s foot (tinea tarsigrade): reduces fungal growth and relieves itching.
• Jock itch (tinea cruris): eliminates the causative fungus and improves skin integrity.
• Ringworm (tinea corporea): clears the infection and prevents spread to other body sites.
• Yeast infection (candidal dermatitis): controls Candida overgrowth on the skin.

• Tioconazole inhibits the fungal enzyme lanosterol 14‑α‑demethylase, disrupting the synthesis of ergosterol, an essential component of fungal cell membranes. This blockage compromises membrane integrity, leading to increased permeability and ultimately fungal cell death.

Adverse reactions to topical tioconazole are generally mild and limited to the application site.

Common Side Effects

• Burning sensation: mild transient heat.
• Itching: occasional pruritus at the site.
• Redness: mild erythema.
• Dryness: skin may feel less moist.
• Stinging: brief sharp sensation.
• Peeling: superficial desquamation.

Serious or Rare Side Effects

• Contact dermatitis: allergic skin reaction.
• Severe swelling: localized edema.
• Blister formation: vesicle development.
• Widespread rash: extensive cutaneous eruption.
• Systemic absorption effects: rare systemic toxicity.
• Persistent ulceration: non‑healing skin breakdown.

When using Onisid, follow these safety measures:

• Avoid application on broken skin: apply only to intact epidermis.
• Limit exposure time: follow prescribed duration of therapy.
• Monitor for allergic reactions: discontinue if severe rash develops.
• Use caution in pregnancy: discuss with a healthcare professional.
• Keep out of children’s reach: store securely.
• Store at ambient temperature: keep in original packaging, protect from moisture and direct sunlight.

Tioconazole has limited systemic absorption, so drug‑interaction potential ​​​.

Major Interactions (Avoid)

• None: no strong contraindicated interactions.

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