Onsudil (Procaterol Hydrochloride)

Onsudil is a β‑adrenergic bronchodilator that acts on the airway smooth‑muscle pathway to improve airflow.

• Asthma: Provides rapid relief of bronchospasm and improves peak expiratory flow.
• Chronic obstructive pulmonary disease (COPD): Helps alleviate reversible airway narrowing during exacerbations.
• Exercise‑induced bronchoconstriction: Prevents airway narrowing associated with physical activity.

• Procaterol hydrochloride binds selectively to β2‑adrenergic receptors on bronchial smooth muscle, activating adenylate cyclase and increasing intracellular cyclic AMP. The rise in cAMP leads to relaxation of smooth muscle fibers, bronchodilation, and improved airway patency.

Adverse reactions reported with β2‑agonist inhalation therapy vary in frequency and severity.

Common Side Effects

• Tremor: Mild, transient shaking of the hands or limbs.
• Headache: Light‑to‑moderate headache occurring shortly after inhalation.
• Palpitations: Noticeable but usually benign increase in heart rate.
• Throat irritation: Mild discomfort or dryness in the throat.
• Cough: Temporary coughing following inhalation of the aerosol.
• Nausea: Mild stomach upset or queasiness.

Serious or Rare Side Effects

• Paradoxical bronchospasm: Worsening of airway obstruction after use.
• Severe tachycardia: Markedly elevated heart rate that may require medical attention.
• Hypokalemia: Low blood potassium levels, potentially leading to muscle weakness.
• Allergic reaction: Rash, itching, swelling, or anaphylaxis in rare cases.

When prescribing Onsudil, clinicians should consider several safety aspects.

• Cardiac monitoring: Patients with known heart disease should be observed for arrhythmias.
• Electrolyte assessment: Check serum potassium in patients at risk of hypokalemia.
• Diabetes management: Monitor blood glucose as β2‑agonists may affect glycemic control.
• Pregnancy and lactation: Use only if the potential benefit outweighs risk.
• Pediatric use: Dose adjustments may be required for children.
• Store at ambient temperature: Keep below 25°C, in the original container, protected from moisture.

Procateryl may interact with several drug classes, requiring attention to avoid reduced efficacy or increased toxicity.

Major Interactions (Avoid)

• Non‑selective β‑blockers: Antagonize the bronchodilatory effect of β2‑agonists.
• Mono‑Mono‑Methyl  ---

Moderate  ---   -  Pharmac​