Product image of Onytec (Ciclopirox) supplied by GNH India

Onytec

Active Ingredient:
Ciclopirox
Origin:
EU

Onytec (Ciclopirox)

Ciclopirox, the active ingredient in Onytec, is an antifungal (hydroxypyridone) presented as a topical formulation for skin and nail use. It treats fungal infections such as athlete's foot, ringworm and nail fungus in adults and children.
GNH India supplies Onytec as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Polichem S.A.

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Indications & Clinical Uses

Ciclopirox acts on a broad range of dermatophytes and yeasts, making it suitable for several superficial fungal infections.

  • Tinea pedis: reduces fungal growth and relieves itching and scaling on the feet.
  • Tinea corporis: clears ring‑shaped skin lesions caused by dermatophytes.
  • Tinea cruris: treats fungal infection of the groin area, decreasing redness and discomfort.
  • Onychomycosis: improves nail appearance by inhibiting fungal colonisation of the nail plate.
  • Candidiasis: controls yeast overgrowth on skin and mucosal surfaces.

How It Works

  • Ciclopirox chelates polyvalent cations such as Fe³⁺ and Al³⁺, inhibiting metal‑dependent enzymes essential for fungal cell metabolism. This disruption interferes with membrane transport, cellular respiration, and DNA repair, ultimately leading to fungal cell death without affecting human cells.

Side Effects

Ciclopirox is generally well tolerated, but local reactions may occur.

Common Side Effects

  • Burning sensation at the application site.
  • Itching or pruritus.
  • Redness or erythema.
  • Scaling or flaking of skin.
  • Dryness of the treated area.
  • Mild irritation or stinging.

Serious or Rare Side Effects

  • Allergic contact dermatitis.
  • Severe skin rash or blistering.
  • Swelling of the treated area.
  • Systemic hypersensitivity reactions.
  • Unexplained fever or malaise.
  • Hepatic enzyme alterations (rare).

Precautions & Warnings

Before using Onytec, consider the following safety measures.

  • Apply to clean, dry skin: ensure the area is free of debris before application.
  • Avoid use on broken or inflamed skin: may increase irritation.
  • Do not cover with occlusive dressings unless directed by a clinician.
  • Discontinue if severe irritation or allergic reaction develops.
  • Consult a healthcare professional if pregnant, planning pregnancy, or breastfeeding.
  • Store at room temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Ciclopirox may interact with other topical agents; monitor for combined effects.

Major Interactions (Avoid)

  • Concurrent use with other topical antifungals: may increase local irritation.
  • Combination with systemic antifungal agents that share metabolic pathways: potential additive toxicity.

Moderate Interactions (Monitor Closely)

  • Use with corticosteroid creams: may mask signs of irritation.
  • Application alongside skin sensitizers: heightened risk of dermatitis.
  • Use with phototherapy: possible photosensitivity.
  • Co‑application with alcohol‑based products: may enhance drying effect.
  • Simultaneous use with topical antibiotics: monitor for secondary infection.

Frequently Asked Questions

Onytec contains ciclopirox and is indicated for superficial fungal infections such as athlete's foot (tinea pedis), body ringworm (tinea corporis), groin infection (tinea cruris), nail fungus (onychomycosis) and skin candidiasis. It is applied topically to the affected area to reduce fungal growth and alleviate symptoms.

Ciclopirox chelates essential metal ions, inhibiting metal‑dependent enzymes required for fungal cell metabolism. This disrupts membrane transport, respiration, and DNA synthesis, leading to fungal cell death while sparing human cells, providing an effective topical antifungal action.

The dosage of Onytec is determined by the prescribing healthcare professional based on the infection type, location, and patient characteristics. The prescriber will specify the amount to apply, frequency, and duration of treatment on the product label or prescription.

Safety data for ciclopirox in pregnancy and lactation are limited. Healthcare providers should weigh the potential benefits against any unknown risks before prescribing Onytec to pregnant or nursing individuals. Consultation with a physician is recommended.

To order Onytec, submit an enquiry on the product page at gnhindia.com, indicating the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Onytec (ciclopirox) belongs to the hydroxypyridone class, offering a broad spectrum against dermatophytes and yeasts. Unlike azole or allylamine agents, ciclopirox works by metal chelation rather than inhibiting ergosterol synthesis, which can be advantageous in resistant strains and may result in a different side‑effect profile.

Onytec should be stored at room temperature, below 25 °C, in its original packaging. Keep the container tightly closed, protect it from moisture and direct sunlight, and ensure it is out of reach of children.

Apply a thin layer of Onytec to clean, dry skin or nail surfaces as directed by the prescriber. Typically, the product is rubbed gently into the affected area once or twice daily, avoiding contact with eyes and mucous membranes unless instructed otherwise.

Serious risks, though rare, include allergic contact dermatitis, severe skin reactions such as blistering or swelling, and systemic hypersensitivity. Patients should discontinue use and seek medical attention if they experience any signs of a serious allergic reaction.

Onytec should not be used on severely damaged, ulcerated or inflamed skin, nor on patients with known hypersensitivity to ciclopirox or any excipients in the formulation. Individuals with uncontrolled systemic fungal infections should seek alternative systemic therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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