Product image of Ophtal (Ofloxacin) supplied by GNH India

Ophtal

Active Ingredient:
Ofloxacin
Origin:
EU

Ophtal (Ofloxacin)

Ofloxacin, the active ingredient in Ophtal, is a fluoroquinolone antibiotic presented as an ophthalmic solution for ocular use. It treats bacterial eye infections in adults and children.

GNH India supplies Ophtal as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Dr. Gerhard Mann Chem.-Pharm. Fabrik Gmbh

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Indications & Clinical Uses

Ophtal (ofloxacin) is used to treat bacterial infections of the eye surface and cornea.

  • Bacterial conjunctivitis: reduces bacterial load and alleviates redness and discharge.
  • Corneal ulcer (bacterial keratitis): promotes healing of infected corneal tissue.
  • Blepharitis: controls bacterial overgrowth on eyelid margins.
  • Post‑surgical prophylaxis: prevents infection after ocular surgery.

How It Works

  • Ofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, enzymes essential for DNA replication, transcription, and repair. By binding to these enzymes, it prevents supercoiling of DNA, leading to bacterial cell death. This bactericidal action is effective against a broad range of Gram‑negative and Gram‑positive ocular pathogens.

Side Effects

Adverse reactions may occur with ophthalmic use of ofloxacin.

Common Side Effects

  • Eye irritation or burning sensation.
  • Redness of the conjunctiva.
  • Tearing or increased lacrimation.
  • Foreign body sensation.
  • Blurred vision.
  • Mild eyelid edema.

Serious or Rare Side Effects

  • Allergic eye reaction (e.g., swelling, itching, rash).
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Corneal ulcer worsening or perforation.
  • Severe visual loss.
  • Anaphylaxis (systemic).

Precautions & Warnings

Before using Ophtal, consider the following safety measures.

  • Allergy assessment: confirm no known hypersensitivity to fluoroquinolones.
  • Contact lens use: advise removal of lenses during treatment.
  • Pregnancy and lactation: use only if clearly needed and prescribed.
  • Concomitant ocular steroids: monitor for increased infection risk.
  • Pediatric use: dosage and duration must be determined by a clinician.
  • Store at room temperature: keep in the original container, protect from light and moisture.

Avoid Interactions

Ofloxacin eye drops can interact with systemic medications and other ocular agents.

Major Interactions (Avoid)

  • Systemic fluoroquinolones: avoid concurrent use to reduce cumulative toxicity.
  • Warfarin: may increase anticoagulant effect, monitor INR.
  • Antacids containing aluminum or magnesium: can reduce systemic absorption if taken orally.

Moderate Interactions (Monitor Closely)

  • Topical corticosteroids: may mask infection signs, monitor response.
  • Non‑steroidal anti‑inflammatory eye drops: watch for delayed healing.
  • Other ophthalmic antibiotics: avoid overlapping therapy unless directed.

Frequently Asked Questions

Ophtal is an ophthalmic solution containing ofloxacin, a fluoroquinolone antibiotic. It is prescribed to treat bacterial infections of the eye, including conjunctivitis, corneal ulcers, blepharitis, and to prevent infection after ocular surgery.

Ofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, enzymes required for DNA replication and transcription. This disruption leads to bacterial cell death, providing a bactericidal effect against a broad spectrum of ocular pathogens.

The dosing regimen for Ophtal is determined by the prescribing clinician based on the specific infection, severity, and patient factors. Patients should follow the exact instructions provided by their eye care professional.

Ophtal should be used during pregnancy or lactation only if clearly needed and prescribed by a qualified health professional. The potential benefits must outweigh any possible risks to the fetus or infant.

To order Ophtal, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and necessary import documentation.

Ophtal (ofloxacin) belongs to the fluoroquinolone class, offering broad‑spectrum coverage against Gram‑negative and Gram‑positive bacteria. Compared with older agents like chloramphenicol, ofloxacin generally provides faster bacterial eradication and lower resistance rates, but choice depends on local susceptibility patterns and clinician preference.

Store Ophtal at room temperature, preferably below 25 °C. Keep the bottle in its original packaging, protect it from direct light and moisture, and discard any solution that appears discolored or contaminated.

Ophtal is applied as eye drops. The usual method is to instill the prescribed number of drops into the affected eye(s) at the intervals directed by the eye care professional, typically avoiding contact lens wear during treatment.

Serious risks include severe allergic reactions such as swelling, rash, or anaphylaxis, as well as rare events like Stevens‑Johnson syndrome, toxic epidermal necrolysis, and worsening of corneal ulcers that could lead to vision loss. Immediate medical attention is required if these occur.

Ophtal should not be used by individuals with a known hypersensitivity to ofloxacin, other fluoroquinolones, or any component of the formulation. It is also contraindicated in patients with a history of severe ocular reactions to similar antibiotics.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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