Product image of Opiren Flas (Lansoprazole) supplied by GNH India

Opiren Flas

Active Ingredient:
Lansoprazole
Origin:
EU

Opiren Flas (Lansoprazole)

Lansoprazole, the active ingredient in Opiren Flas, is a proton pump inhibitor presented as a tablet for oral use. It reduces gastric acid secretion and is used to treat conditions such as gastroesophageal reflux disease and peptic ulcer disease in adults.

GNH India supplies Opiren Flas as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Takeda Farmacéutica España S.A

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Indications & Clinical Uses

Lansoprazole acts on the gastric proton pump to lower acid production, benefiting several acid‑related disorders.

  • Gastroesophageal reflux disease (GERD): alleviates heartburn and esophageal irritation by decreasing stomach acid.
  • Peptic ulcer disease: promotes ulcer healing and prevents recurrence through acid suppression.
  • Helicobacter pylori eradication: used in combination therapy to enhance bacterial clearance.
  • Zollinger‑Ellison syndrome: controls excessive gastric acid secretion caused by gastrin‑producing tumors.

How It Works

  • Lansoprazole irreversibly inhibits the H+/K+ ATPase enzyme (gastric proton pump) located in the parietal cells of the stomach. By blocking this final step of acid secretion, it markedly reduces both basal and stimulated gastric acid output, providing long‑lasting acid suppression that facilitates healing of acid‑related mucosal damage.

Side Effects

Lansoprazole may cause a range of adverse reactions, from mild to serious.

Common Side Effects

  • Headache: mild to moderate pain often resolves without treatment.
  • Diarrhea: loose stools that may be transient.
  • Abdominal pain: discomfort or cramping in the stomach area.
  • Nausea: feeling of queasiness, sometimes with vomiting.
  • Constipation: reduced bowel movements.
  • Flatulence: increased gas production.

Serious or Rare Side Effects

  • Severe allergic reactions: rash, swelling, or anaphylaxis requiring immediate medical attention.
  • Clostridioides difficile infection: severe colitis presenting with watery diarrhea.
  • Low magnesium levels: muscle cramps, irregular heartbeat, or seizures.
  • Bone fractures: increased risk with long‑term use, especially in the elderly.
  • Liver enzyme elevation: signs of hepatic dysfunction such as jaundice.

Precautions & Warnings

Before initiating therapy, consider the following safety measures.

  • Assess renal function: adjust use in patients with severe kidney impairment.
  • Monitor magnesium: check serum levels during prolonged treatment.
  • Limit duration: avoid unnecessary long‑term use to reduce fracture risk.
  • Evaluate pregnancy status: discuss potential risks with a healthcare professional.
  • Review concomitant medications: consider possible drug‑drug interactions.
  • Store at ambient temperature: keep below 25 °C, in the original container, protected from moisture and direct sunlight.

Avoid Interactions

Lansoprazole can affect the absorption or metabolism of several drugs.

Major Interactions (Avoid)

  • Atazanavir: reduced antiviral efficacy due to decreased absorption.
  • Nelfinavir: lowered plasma concentrations compromising HIV treatment.
  • Rilpivirine: diminished exposure leading to suboptimal viral suppression.

Moderate Interactions (Monitor Closely)

  • Clopidogrel: reduced activation may lessen antiplatelet effect.
  • Warfarin: potential increase in INR, requiring closer monitoring.
  • Methotrexate: increased toxicity risk, especially at high doses.
  • Digoxin: possible increase in serum levels, necessitating dose adjustment.

Frequently Asked Questions

Opiren Flas contains lansoprazole, which is prescribed to manage acid‑related disorders such as gastroesophageal reflux disease, peptic ulcer disease, Helicobacter pylori infection (as part of combination therapy), and Zollinger‑Ellison syndrome. By lowering stomach acid, it helps relieve symptoms and promotes healing of the gastrointestinal lining.

Lansoprazole targets the H+/K+ ATPase enzyme, also known as the gastric proton pump, located in the stomach’s parietal cells. It binds irreversibly to this pump, blocking the final step of acid secretion, which leads to a sustained reduction in gastric acidity and creates a less hostile environment for ulcer healing.

The appropriate dose of Opiren Flas is determined by the prescribing healthcare professional based on the specific indication, patient age, renal function, and treatment duration. Patients should follow the exact regimen provided by their clinician and not adjust the dose without medical advice.

Safety data for lansoprazole in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any possible risk to the fetus. Breastfeeding mothers should consult their physician, as the drug does pass into breast milk in small amounts.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Lansoprazole belongs to the proton pump inhibitor (PPI) class, which generally provides more potent and longer‑lasting acid suppression than H2‑receptor antagonists such as ranitidine. Compared with other PPIs, lansoprazole has a similar efficacy profile but may differ slightly in metabolism and drug‑interaction potential.

Store Opiren Flas at ambient temperature, preferably below 25 °C. Keep the tablets in their original packaging, protect them from moisture, excessive heat, and direct sunlight to maintain potency throughout the shelf life.

Opiren Flas is taken orally, usually as a whole tablet with a glass of water. It can be taken with or without food, but consistency in relation to meals helps maintain stable drug levels. Patients should swallow the tablet whole and not crush or chew it.

Serious risks include severe allergic reactions such as anaphylaxis, Clostridioides difficile‑associated colitis, low magnesium levels that may cause cardiac arrhythmias, and an increased risk of bone fractures with long‑term use. Any signs of these conditions require immediate medical evaluation.

Patients with known hypersensitivity to lansoprazole or other PPIs should not use Opiren Flas. Caution is also advised for individuals with severe liver disease, those taking medications that have major interactions (e.g., atazanavir, nelfinavir), and patients who are pregnant or breastfeeding unless the benefits outweigh the risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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