Opokan Actigel (Naproxen)

Opokan Actigel contains naproxen, a non‑steroidal anti‑inflammatory that acts on inflammatory pathways in the musculoskeletal system.

• Osteoarthritis: reduces joint pain and improves mobility.
• Rheumatoid arthritis: alleviates joint inflammation and stiffness.
• Acute musculoskeletal injuries: eases pain and swelling from sprains, strains and bruises.

• Naproxen inhibits cyclo‑oxygenase (COX‑1 and COX‑2) enzymes, decreasing the conversion of arachidonic acid to prostaglandins. Lower prostaglandin levels reduce inflammation, pain signalling and fever, providing symptomatic relief at sites of tissue injury.

Adverse reactions to topical naproxen are generally mild and localized.

Common Side Effects

• Skin redness at application site: mild erythema may appear.
• Itching or mild rash: occasional pruritus around the gel area.
• Dryness or peeling: slight desquamation of the treated skin.

Serious or Rare Side Effects

• Severe skin reaction: signs of dermatitis, blistering or ulceration.
• Systemic NSAID effects: gastrointestinal bleeding or ulceration if absorbed in large amounts.
• Allergic anaphylaxis: rapid onset of swelling, difficulty breathing or hives.
• Liver enzyme elevation: abnormal liver function tests in rare cases.
• Renal impairment: reduced kidney function noted in susceptible individuals.

When using Opokan Actigel, follow these safety considerations:

• Avoid application on broken or infected skin: may increase systemic absorption.
• Do not use with other topical NSAIDs: risk of additive irritation.
• Monitor for gastrointestinal symptoms: report persistent stomach pain or bleeding.
• Caution in patients with cardiovascular disease: NSAIDs can affect clotting.
• Store at ambient temperature: keep in the original packaging, protect from moisture and direct sunlight.

Naproxen may interact with several drug classes, requiring attention to avoid adverse effects.

Major Interactions (Avoid)

• Anticoagulants (e.g., warfarin): increased risk of bleeding.
• Selective serotonin reuptake inhibitors (SSRIs): heightened bleeding tendency.
• Other NSAIDs or COX‑2 inhibitors: additive gastrointestinal toxicity.

Moderate Interaction (Monitor Closely):

• ACE inhibitors: may reduce renal perfusion.
• Diuretics: potential for decreased kidney function.
• Lithium: napier t may increase lithium levels.
• Corticial c    

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