Product image of Optiray (Ioversol) supplied by GNH India

Optiray

Active Ingredient:
Ioversol
Origin:
EU

Optiray (Ioversol)

Ioversol, the active ingredient in Optiray, is an iodinated contrast agent presented as a solution for injection for intraarterial and intravenous use. It provides radiographic contrast to enhance the visibility of vascular structures and organs during diagnostic imaging procedures.
GNH India supplies Optiray as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Pharmacol D.O.O.

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Indications & Clinical Uses

Optiray (ioversol) is used as an iodinated contrast medium in radiographic procedures to improve visualization of vascular and organ structures.

  • Angiography: enhances the delineation of blood vessels for accurate assessment.
  • Computed tomography (CT) imaging: provides contrast to differentiate tissues and detect lesions.
  • Urography: improves imaging of the urinary tract for diagnosis of obstruction or disease.
  • Cystography: facilitates clear visualization of the bladder.
  • Myelography: aids in detailed imaging of the spinal canal and nerve roots.

How It Works

  • Ioversol contains a high concentration of iodine atoms that absorb X‑ray photons, increasing the radiodensity of blood and tissues where it distributes. After intravenous or intra‑arterial administration, the agent circulates through the vascular system, temporarily attenuating X‑rays and producing enhanced contrast on radiographic, CT, and fluoroscopic images, thereby allowing clearer delineation of anatomical structures.

Side Effects

Adverse reactions may occur following administration of iodinated contrast agents such as ioversol.

Common Side Effects

  • Warmth or flushing sensation during injection.
  • Metallic taste in the mouth.
  • Mild nausea or vomiting.
  • Transient headache.
  • Mild urticaria or skin itching.
  • Temporary increase in blood pressure.

Serious or Rare Side Effects

  • Severe allergic reaction or anaphylaxis.
  • Contrast‑induced nephropathy leading to renal impairment.
  • Hypotension or cardiovascular collapse.
  • Pulmonary edema or respiratory distress.
  • Seizures or neurological disturbances.
  • Cardiac arrhythmias.

Precautions & Warnings

Use of Optiray requires careful assessment of patient risk factors and appropriate preparation.

  • Renal function assessment: evaluate serum creatinine and eGFR before administration.
  • Allergy history: screen for prior reactions to iodinated contrast or related substances.
  • Hydration: ensure adequate fluid intake to reduce nephrotoxic risk.
  • Dose minimization: use the lowest effective volume for the intended imaging study.
  • Thyroid monitoring: consider iodine load effects in patients with thyroid disorders.
  • Store at ambient temperature: keep below 25°C, protect from moisture and light, and retain in original packaging.

Avoid Interactions

Ioversol may interact with other medications, affecting safety and efficacy.

Major Interactions (Avoid)

  • Nephrotoxic agents (e.g., aminoglycosides, high‑dose NSAIDs): increase risk of renal injury.
  • Iodine‑containing drugs (e.g., amiodarone, thyroid hormone): may exacerbate thyroid dysfunction.
  • Metformin: risk of lactic acidosis in renal impairment; consider temporary discontinuation.

Moderate Interactions (Monitor Closely)

  • Diuretics: may alter fluid balance and affect contrast distribution.
  • Beta‑blockers: can mask hypotensive responses.
  • ACE inhibitors or ARBs: may increase susceptibility to contrast‑induced nephropathy.
  • Anticoagulants: heightened bleeding risk during invasive imaging procedures.

Frequently Asked Questions

Optiray, containing the active ingredient ioversol, is an iodinated contrast medium used in diagnostic imaging procedures such as angiography, computed tomography (CT), urography, cystography, and myelography. It enhances the visibility of blood vessels and organs by increasing radiodensity, allowing clinicians to obtain clearer images for accurate diagnosis.

Ioversol works by providing a high concentration of iodine atoms that absorb X‑ray photons. When injected intravenously or intra‑arterially, it circulates through the vascular system and temporarily attenuates X‑rays, creating a contrast difference between blood‑filled structures and surrounding tissues. This contrast improves the delineation of anatomical features on radiographic and CT images.

The specific dose of Optiray is determined by the prescribing physician based on the type of imaging study, patient weight, renal function, and clinical protocol. Healthcare professionals calculate the appropriate volume to achieve optimal image quality while minimizing potential risks.

The safety of Optiray in pregnancy or while breastfeeding has not been definitively established. Use during pregnancy should be considered only if the diagnostic benefit outweighs potential risks, and the decision should be made by the treating physician. Breastfeeding mothers should consult their healthcare provider for guidance.

To order Optiray, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide. After receiving the request, the sales team will verify trade or institutional credentials, then provide pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Optiray (ioversol) is a non‑ionic, low‑osmolality iodinated contrast agent, offering a favorable safety profile compared with older high‑osmolality agents. Compared with other low‑osmolality agents, ioversol provides comparable image quality and a similar incidence of mild adverse reactions, while maintaining a reduced risk of severe nephrotoxicity.

Optiray should be stored at ambient temperature, preferably below 25 °C. Keep the solution in its original container, protect it from direct sunlight, moisture, and extreme temperature fluctuations. Do not freeze the product, and ensure the vial is sealed until ready for use.

Optiray is administered by a qualified healthcare professional via intra‑arterial or intravenous injection, depending on the imaging procedure. The injection is typically performed using a power injector or manual bolus, following the specific protocol for the diagnostic study to achieve optimal contrast enhancement.

The most serious risks include severe allergic reactions (anaphylaxis), contrast‑induced nephropathy leading to acute kidney injury, hypotension or cardiovascular collapse, and rare pulmonary edema. Patients with known severe iodine allergy, compromised renal function, or uncontrolled thyroid disease require careful assessment before administration.

Optiray should be avoided in patients with a documented severe hypersensitivity to iodinated contrast agents, uncontrolled hyperthyroidism, or those with severe renal impairment (eGFR <30 mL/min/1.73 m²) unless the diagnostic benefit justifies the risk. Clinicians must evaluate each patient’s medical history before use.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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