Product image of Opustan (Mefenamic Acid) supplied by GNH India

Opustan

Active Ingredient:
Mefenamic Acid
Origin:
EU

Opustan (Mefenamic Acid)

Mefenamic Acid, the active ingredient in Opustan, is a Nonsteroidal anti-inflammatory drug (NSAID) presented as a tablet for oral use. It relieves mild to moderate pain, dysmenorrhea, and inflammatory musculoskeletal conditions in adults.

GNH India supplies Opustan as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Mercury Pharmaceuticals Ltd.

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Indications & Clinical Uses

Opustan, a NSAID, acts on inflammatory pathways to provide analgesic and antipyretic effects.

  • Mild to moderate pain: reduces pain intensity in conditions such as headache, dental pain, and postoperative discomfort.
  • Dysmenorrhea: alleviates menstrual cramps by decreasing uterine prostaglandin production.
  • Inflammatory musculoskeletal conditions: improves mobility and reduces swelling in arthritis and soft‑tissue injuries.

How It Works

  • Mefenamic Acid non‑selectively inhibits cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, leading to decreased synthesis of prostaglandins and thromboxanes. This reduction dampens the inflammatory cascade, resulting in lowered pain perception, reduced fever, and diminished tissue swelling.

Side Effects

Adverse reactions may occur with Opustan use.

Common Side Effects

  • Gastrointestinal discomfort: nausea, dyspepsia, or abdominal pain.
  • Headache: mild to moderate intensity.
  • Dizziness or vertigo: transient episodes.

Serious or Rare Side Effects

  • Gastrointestinal ulceration or bleeding: may present with melena or hematemesis.
  • Renal impairment: reduced kidney function or acute renal failure.
  • Severe hypersensitivity: rash, angioedema, or anaphylactic reactions.

Precautions & Warnings

Opustan should be used with caution in certain situations.

  • Cardiovascular risk: avoid in patients with established coronary artery disease.
  • Renal function: monitor kidney parameters in patients with pre‑existing renal impairment.
  • Hepatic disease: use carefully in individuals with liver dysfunction.
  • Concomitant anticoagulants: increase bleeding risk; monitor coagulation status.
  • Pregnancy and lactation: safety not established; discuss risks with a healthcare professional.
  • Store below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Opustan can interact with several medications.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): heightened bleeding risk.
  • Other NSAIDs or aspirin: increased gastrointestinal toxicity.
  • Lithium: elevated serum lithium levels.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: possible reduction in renal function.
  • Diuretics: risk of reduced renal perfusion.
  • Methotrexate: potential for increased toxicity.

Frequently Asked Questions

Opustan contains mefenamic acid, an NSAID indicated for the relief of mild to moderate pain, treatment of dysmenorrhea, and reduction of inflammation in musculoskeletal conditions such as arthritis or soft‑tissue injuries.

Mefenamic acid inhibits both COX‑1 and COX‑2 enzymes, decreasing prostaglandin synthesis. This action reduces inflammation, lowers fever, and diminishes pain signals, providing analgesic and antipyretic effects.

The dosage of Opustan is determined by the prescribing clinician based on the patient's condition, age, and response. Specific dosing regimens should be obtained from the healthcare provider.

Safety of mefenamic acid in pregnancy and lactation has not been firmly established. It should only be used if the potential benefit justifies the potential risk, and the decision must be made by a qualified healthcare professional.

Enquiries can be submitted on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and import documentation.

Opustan (mefenamic acid) is a non‑selective NSAID similar to ibuprofen and naproxen but has a distinct pharmacokinetic profile and may be preferred for dysmenorrhea. Choice of NSAID depends on efficacy, tolerability, patient comorbidities, and physician preference.

Store Opustan below 25 °C in the original packaging, protecting it from moisture and direct sunlight to maintain product stability and potency.

Opustan is taken orally, usually with a full glass of water. It may be taken with food or milk to lessen gastrointestinal irritation, but it should be swallowed whole and not chewed or crushed.

Serious risks include gastrointestinal ulceration or bleeding, renal impairment, and severe hypersensitivity reactions such as anaphylaxis. Patients should be monitored for signs of bleeding, kidney dysfunction, or allergic responses.

Opustan is contraindicated in individuals with known hypersensitivity to mefenamic acid or other NSAIDs, those with active peptic ulcer disease, severe renal or hepatic impairment, and patients receiving anticoagulant therapy where bleeding risk is unacceptable.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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