Product image of Orabloc Adrenalinee (Articaine Hydrochloride, Epinephrine) supplied by GNH India

Orabloc Adrenalinee

Active Ingredient:
Articaine Hydrochloride, Epinephrine
Origin:
EU

Orabloc Adrenalinee (Articaine Hydrochloride, Epinephrine)

Articaine Hydrochloride, the active ingredient in Orabloc Adrenalinee, is a local anesthetic (amide) presented as a dental solution for local administration use. It provides reversible loss of sensation for dental procedures and oral surgery. Epinephrine is included as a vasoconstrictor to prolong the anesthetic effect and reduce bleeding.

GNH India supplies Orabloc Adrenalinee as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Pierrel S.P.A.

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

Orabloc Adrenalinee, a dental local anesthetic, is used to achieve reversible loss of sensation in oral tissues during various procedures.

  • Dental extractions: provides rapid onset anesthesia for tooth removal.
  • Periodontal surgery: facilitates pain‑free manipulation of gum tissue.
  • Restorative dentistry (fillings, crowns): ensures patient comfort during drilling and placement.
  • Oral surgery: enables analgesia during surgical removal of impacted teeth.
  • Endodontic therapy: allows painless root canal treatment.

How It Works

  • Articaine Hydrochloride blocks voltage‑gated sodium channels on neuronal membranes, preventing depolarization and nerve impulse propagation. Epinephrine acts on α‑adrenergic receptors causing vasoconstriction, which reduces local blood flow, prolongs the anesthetic effect, and minimizes systemic absorption. The combined action results in rapid, localized numbness with extended duration suitable for dental procedures.

Side Effects

Adverse reactions may occur following administration of Orabloc Adrenalinee.

Common Side Effects

  • Transient lip or cheek numbness.
  • Temporary taste alteration.
  • Mild headache.
  • Localized swelling at injection site.
  • Slight dizziness.

Serious or Rare Side Effects

  • Allergic reaction including anaphylaxis.
  • Cardiovascular toxicity such as arrhythmia or hypertension.
  • Methemoglobinemia (rare).
  • Seizures due to high systemic absorption.
  • Persistent paresthesia.

Precautions & Warnings

Use of Orabloc Adrenalinee requires careful assessment and monitoring.

  • Allergy assessment: verify no known hypersensitivity to amide anesthetics or epinephrine.
  • Cardiovascular status: use cautiously in patients with uncontrolled hypertension.
  • Drug interactions: avoid concurrent MAO inhibitors that may potentiate epinephrine effects.
  • Pregnancy: assess risk–benefit; limited data available.
  • Pediatric use: dose must be determined by clinician based on weight.
  • Store at room temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Orabloc Adrenalinee may interact with other medications; awareness of interaction severity is essential.

Major Interactions (Avoid)

  • Non‑selective β‑blockers: may enhance epinephrine‑induced tachycardia.
  • Tricyclic antidepressants: increase risk of cardiovascular stimulation.

Moderate Interactions (Monitor Closely)

  • Monoamine oxidase inhibitors: may potentiate vasoconstrictor effects.
  • Diuretics: may affect blood pressure response.
  • Other local anesthetics: cumulative toxicity risk.

Frequently Asked Questions

Orabloc Adrenalinee is a dental local anesthetic used to provide reversible numbness during tooth extractions, periodontal surgery, restorative procedures, oral surgery, and endodontic therapy. The combination of articaine and epinephrine offers rapid onset and prolonged analgesia, helping clinicians perform procedures with reduced patient discomfort.

Articaine hydrochloride blocks voltage‑gated sodium channels on nerve membranes, preventing the initiation and propagation of action potentials. This inhibition stops pain signals from reaching the brain. Epinephrine, added to the formulation, constricts local blood vessels, extending the anesthetic effect and limiting systemic absorption.

The appropriate dose of Orabloc Adrenalinee is determined by the prescribing clinician based on the specific dental procedure, patient age, weight, and overall health. Only a qualified healthcare professional should calculate and administer the correct amount.

Safety data for Orabloc Adrenalinee in pregnancy and lactation are limited. Clinicians should evaluate the potential benefits against possible risks before prescribing to pregnant or nursing patients, and use the lowest effective dose if deemed necessary.

To order Orabloc Adrenalinee, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide, and will request trade or institutional credentials before providing pricing, availability, shipping details, and any necessary import documentation.

Orabloc Adrenalinee combines articaine, which has a high lipid solubility for rapid onset, with epinephrine to prolong effect and reduce bleeding. Compared with lidocaine‑based formulations, articaine often provides faster anesthesia and may be effective at lower concentrations, though individual patient response can vary.

Store Orabloc Adrenalinee at room temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct light, and ensure the container is tightly sealed to maintain sterility and potency.

Orabloc Adrenalinee is administered by a qualified dental professional via local infiltration or nerve block injection directly into the oral tissues. The solution is injected into the target area using a sterile syringe and needle, allowing rapid onset of anesthesia.

Serious risks include allergic reactions such as anaphylaxis, cardiovascular events like arrhythmia or severe hypertension due to epinephrine, and rare cases of methemoglobinemia. Clinicians should monitor patients closely for any signs of these adverse events during and after administration.

Patients with known hypersensitivity to amide‑type local anesthetics or epinephrine, those with uncontrolled hypertension, certain cardiac conditions, or who are taking non‑selective β‑blockers should avoid using Orabloc Adrenalinee unless a clinician determines that benefits outweigh the risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.