Product image of Orabloc (Articaine Hydrochloride, Epinephrine) supplied by GNH India

Orabloc

Active Ingredient:
Articaine Hydrochloride, Epinephrine
Origin:
EU

Orabloc (Articaine Hydrochloride, Epinephrine)

Articaine hydrochloride, the active ingredient in Orabloc, is a local anesthetic (amide) presented as a dental injection for local administration use. It provides reversible inhibition of neuronal sodium channels and is combined with epinephrine to achieve prolonged anesthesia for dental procedures.
GNH India supplies Orabloc as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Pierrel S.P.A.

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Indications & Clinical Uses

Orabloc, a dental local anesthetic, is used to achieve numbness in oral tissues during various procedures.

  • Tooth extraction: provides profound local anesthesia to facilitate painless removal of teeth.
  • Restorative dentistry: enables comfortable placement of fillings, crowns, and bridges.
  • Periodontal surgery: allows effective pain control during gum grafts, pocket reduction, and other periodontal interventions.

How It Works

  • Articaine hydrochloride blocks voltage‑gated sodium channels in neuronal membranes, preventing depolarization and nerve impulse transmission. The added epinephrine causes vasoconstriction at the injection site, reducing systemic absorption and extending the duration of anesthesia.

Side Effects

Common Side Effects

  • Transient numbness or tingling at the injection site.
  • Mild pain or pressure sensation during injection.
  • Local bruising or swelling.
  • Headache.
  • Metallic taste.
  • Temporary lip or tongue numbness.

Serious or Rare Side Effects

  • Allergic reaction (rash, itching, swelling, anaphylaxis).
  • Seizures or convulsions.
  • Cardiac arrhythmias or hypertension due to epinephrine.
  • Prolonged soft‑tissue anesthesia.
  • Methemoglobinemia (rare).

Precautions & Warnings

Before administration, consider the following precautions:

  • Allergy assessment: verify no known hypersensitivity to amide‑type anesthetics or epinephrine.
  • Cardiovascular status: use caution in patients with uncontrolled hypertension or significant cardiac disease.
  • Drug interactions: review concurrent use of non‑selective beta‑blockers or MAO inhibitors.
  • Pregnancy and lactation: evaluate risk‑benefit ratio; limited data are available.
  • Pediatric use: adjust dose according to weight and clinical need.
  • Store at ambient temperature: keep below 25 °C, protect from moisture and direct sunlight.

Avoid Interactions

Artabloc may interact with several medication classes.

Major Interactions (Avoid)

  • Non‑selective beta‑blockers: may potentiate epinephrine‑induced hypertension.
  • Monoamine oxidase inhibitors (MAOIs): increased risk of hypertensive crisis.
  • Tricyclic antidepressants: may enhance cardiovascular effects of epinephrine.

Moderate Interactions (Monitor Closely)

  • Other local anesthetics: cumulative toxicity risk.
  • Antihypertensive agents (e.g., clonidine): may blunt epinephrine response.
  • Sympathomimetic drugs: additive cardiovascular stimulation.

Frequently Asked Questions

Orabloc is a dental local anesthetic used to numb oral tissues during procedures such as tooth extractions, restorative work, and periodontal surgery. The combination of articaine and epinephrine provides rapid onset and prolonged pain control.

Articaine blocks voltage‑gated sodium channels on nerve membranes, preventing the generation and propagation of action potentials. Epinephrine constricts local blood vessels, slowing systemic absorption and extending the anesthetic effect.

The specific dose of Orabloc is determined by the prescribing dentist or oral surgeon based on the procedure, patient size, and clinical judgment. Only a qualified healthcare professional should set the dosage.

Safety data for articaine with epinephrine in pregnancy and lactation are limited. The prescriber should weigh potential benefits against risks and consider alternative anesthetics if uncertainty exists.

Submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with lidocaine, articaine has higher lipid solubility, allowing deeper tissue penetration and a slightly faster onset. The added epinephrine prolongs anesthesia, similar to other vasoconstricted formulations, but the overall safety profile remains comparable when used as directed.

Store Orabloc at ambient temperature, preferably below 25 °C. Keep the vial in its original packaging, protect it from moisture and direct sunlight, and avoid freezing.

Orabloc is administered by a qualified dental professional as a local injection into the target tissue. The injection technique (infiltration, block, or intra‑pulpal) depends on the specific procedure and anatomical considerations.

Serious risks include allergic reactions (including anaphylaxis), seizures, and cardiovascular events such as hypertension or arrhythmias caused by epinephrine. Immediate medical attention is required if any of these occur.

Patients with known hypersensitivity to amide‑type local anesthetics or epinephrine, those with uncontrolled severe hypertension, certain cardiac conditions, or who are taking MAO inhibitors should avoid Orabloc unless a risk‑benefit assessment justifies its use.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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