Product image of Orabloc (Articaine Hydrochloride, Epinephrine) supplied by GNH India

Orabloc

Active Ingredient:
Articaine Hydrochloride, Epinephrine
Origin:
EU

Orabloc (Articaine Hydrochloride, Epinephrine)

Articaine hydrochloride, the active ingredient in Orabloc, is a local anesthetic (amide type) presented as a solution for dental intra‑oral administration. It provides rapid onset of numbness for a range of dental procedures and is combined with epinephrine to extend its effect.
GNH India supplies Orabloc as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Pierrel S.P.A.

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Indications & Clinical Uses

Orabloc is a local anesthetic used in dental practice to achieve reversible loss of sensation in targeted oral tissues.

  • Restorative dentistry: provides numbness for cavity preparation and filling placement.
  • Oral surgery: enables pain control during extractions, implant placement, and biopsy procedures.
  • Periodontal therapy: facilitates patient comfort during scaling, root planing, and flap surgery.

How It Works

  • Articaine hydrochloride blocks voltage‑gated sodium channels on neuronal membranes, preventing depolarisation and impulse transmission. Epinephrine acts as a vasoconstrictor, reducing local blood flow, which prolongs the anesthetic effect and limits systemic absorption, resulting in a rapid and sustained loss of sensation in the treated area.

Side Effects

Common Side Effects

  • Transient lip or cheek numbness: temporary sensation loss that resolves as the drug wears off.
  • Mild taste disturbance: brief metallic or bitter taste in the mouth.
  • Mild headache: occasional headache during or after the procedure.

Serious or Rare Side Effects

  • Allergic reaction (anaphylaxis): severe hypersensitivity requiring immediate medical attention.
  • Cardiovascular toxicity (arrhythmia): irregular heart rhythm due to epinephrine excess.
  • Methemoglobinemia (rare): reduced oxygen‑carrying capacity of blood, presenting with cyanosis.

Precautions & Warnings

Before using Orabloc, clinicians should consider the following precautions:

  • Allergy assessment: verify no known hypersensitivity to amide‑type anesthetics or epinephrine.
  • Cardiovascular status: use caution in patients with uncontrolled hypertension or arrhythmias.
  • Drug interactions: avoid concomitant use of non‑selective β‑blockers that may amplify epinephrine effects.
  • Pregnancy and lactation: assess risk–benefit ratio before administration.
  • Store at room temperature below 25°C: keep in the original container, protect from light and moisture.

Avoid Interactions

When prescribing Orabloc, be aware of potential drug interactions.

Major Interactions (Avoid)

  • Non‑selective β‑blockers: may potentiate epinephrine‑induced tachycardia.
  • Tricyclic antidepressants: increase risk of cardiac arrhythmia.
  • MAO inhibitors: risk of hypertensive crisis.

Moderate Interactions (Monitor Closely)

  • Antihistamines: may mask early signs of an allergic reaction.
  • Diuretics: may enhance epinephrine‑related blood pressure changes.

Frequently Asked Questions

Orabloc is used to provide local anesthesia during dental procedures. It numbs the targeted oral tissues, allowing dentists to perform restorative work, extractions, implant placement, and periodontal therapy without causing pain to the patient.

Articaine blocks voltage‑gated sodium channels on nerve cells, preventing the generation and propagation of nerve impulses. This results in a rapid loss of sensation in the area where it is injected.

The dose of Orabloc is determined by the prescribing dentist based on the specific procedure, patient age, weight, and medical history. Only a qualified healthcare professional should decide the appropriate amount.

Safety in pregnancy and lactation has not been fully established. Clinicians should weigh the potential benefits against possible risks and consider alternative anesthetic options when treating pregnant or nursing patients.

To order Orabloc, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Orabloc contains articaine, which has a higher lipid solubility than lidocaine, allowing faster onset and deeper penetration. The added epinephrine prolongs the anesthetic effect, making it comparable or superior to many lidocaine‑based formulations for lengthy procedures.

Orabloc should be stored at room temperature below 25 °C, in its original packaging, protected from light and moisture. Do not freeze the product, and keep it out of reach of children.

Orabloc is administered by local intra‑oral injection. The dentist injects the solution into the soft tissue adjacent to the target area, ensuring precise delivery for effective numbness during the dental procedure.

The most serious risks include severe allergic reactions such as anaphylaxis, cardiovascular toxicity like arrhythmias due to epinephrine, and, rarely, methemoglobinemia. Immediate medical attention is required if any of these symptoms occur.

Patients with a known hypersensitivity to amide‑type local anesthetics or epinephrine, those with uncontrolled hypertension, certain cardiac conditions, or who are taking MAO inhibitors should avoid using Orabloc unless a specialist determines it is safe.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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