Product image of Oralair (Allergen Extract From Pollen Of Dactylis Glomerata, Anthoxanthum Odoratum, Lolium Perenne, Poa Prate) supplied by GNH India

Oralair

Active Ingredient:
Allergen Extract From Pollen Of Dactylis Glomerata, Anthoxanthum Odoratum, Lolium Perenne, Poa Prate
Origin:
EU

Oralair (Allergen Extract From Pollen Of Dactylis Glomerata, Anthoxanthum Odoratum, Lolium Perenne, Poa Prate)

Allergen Extract from Pollen of Dactylis glomerata, Anthoxanthum odoratum, Lolium perenne, Poa pratensis, the active ingredient in Oralair, is a allergen immunotherapy presented as a sublingual tablet for sublingual use. It treats seasonal allergic rhinitis and allergic rhinoconjunctivitis caused by grass pollen in patients with documented sensitivity.

GNH India supplies Oralair as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Stallergenes

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Indications & Clinical Uses

Oralair is indicated for grass‑pollen related allergic conditions and works through allergen‑specific immunotherapy.

  • Seasonal allergic rhinitis (grass pollen): reduces nasal congestion, sneezing, itching and watery eyes.
  • Grass‑pollen‑induced allergic rhinoconjunctivitis: improves both nasal and ocular symptoms.
  • Documented grass‑pollen allergy: provides long‑term immune tolerance to reduce symptom severity over the pollen season.

How It Works

  • Repeated sublingual exposure to the grass‑pollen allergen extract induces immune tolerance by promoting regulatory T‑cell activity and increasing allergen‑specific IgG4 antibodies, while decreasing IgE‑mediated mast cell activation. This shift in the immune response reduces hypersensitivity to grass pollen and mitigates clinical symptoms during exposure.

Side Effects

Oralair may cause local and systemic reactions.

Common Side Effects

  • Oral itching or tingling.
  • Throat irritation or mild swelling.
  • Ear itching.
  • Mild gastrointestinal discomfort.
  • Headache.
  • Transient cough.

Serious or Rare Side Effects

  • Anaphylaxis or severe systemic allergic reaction.
  • Severe oral or facial edema.
  • Urticaria (hives).
  • Angioedema affecting airway.
  • Respiratory distress or bronchospasm.
  • Cardiovascular collapse.

Precautions & Warnings

Before initiating therapy, consider the following precautions.

  • Contraindication: known hypersensitivity to the product or its excipients.
  • Severe uncontrolled asthma: avoid use until asthma is well‑controlled.
  • Acute allergic episode: postpone dosing during active severe symptoms.
  • Pregnancy and breastfeeding: safety not established; discuss with a healthcare professional.
  • Concomitant immunotherapy: monitor for additive allergen exposure.
  • Store at ambient temperature below 25°C: keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Oralair may interact with other medications; monitor as indicated.

Major Interactions (Avoid)

  • Beta‑blockers: may blunt response to emergency treatment of anaphylaxis.
  • ACE inhibitors: may increase risk of angioedema.

Moderate Interactions (Monitor Closely)

  • Antihistamines: may mask local side effects, adjust observation.
  • Systemic corticosteroids: may reduce observable efficacy of immunotherapy.
  • Other allergen immunotherapies: cumulative allergen load may increase reaction risk.

Frequently Asked Questions

Oralair is a prescription sublingual tablet that provides allergen immunotherapy for patients with seasonal allergic rhinitis or allergic rhinoconjunctivitis caused by grass‑pollen exposure. It is intended to reduce symptoms such as sneezing, nasal congestion, and itchy eyes by inducing long‑term immune tolerance.

The allergen extract contains pollen proteins from several grass species. When placed under the tongue, it is absorbed through the oral mucosa, repeatedly exposing the immune system to the allergens. This promotes regulatory T‑cell activity and IgG4 antibody production, which together suppress IgE‑mediated allergic responses and build tolerance over time.

The dosing regimen for Oralair is individualized by the prescribing physician based on the patient’s age, allergy severity, and clinical response. The prescriber determines the initial dose, titration schedule, and maintenance dose, and patients should follow the specific instructions provided on the prescription label.

Safety data for Oralair in pregnancy and lactation are limited, and the product’s pregnancy category is listed as unknown. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their healthcare provider before starting therapy.

To request Oralair, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will ask for trade or institutional credentials. After verification, the sales team provides pricing, availability, shipping details (including any cold‑chain requirements), and assists with import documentation.

Oralair is a sublingual tablet, offering the convenience of at‑home administration compared with subcutaneous immunotherapy (SCIT) that requires clinic visits for injections. Compared with other SLIT tablets such as Grastek, Oralair contains a broader mix of grass‑pollen extracts, which may provide coverage for a wider range of grass species. Choice depends on physician assessment, patient preference, and regional availability.

Oralair tablets should be stored at ambient temperature below 25 °C, in their original blister pack, protected from moisture and direct sunlight. Do not refrigerate or freeze the tablets. Keep them out of reach of children and discard any tablet that appears damaged or discolored.

The tablet is placed under the tongue and allowed to dissolve completely without swallowing or chewing. Patients should remain in an upright position and avoid eating or drinking for at least 30 minutes after administration to ensure optimal absorption through the oral mucosa.

The most serious risks include systemic allergic reactions such as anaphylaxis, severe oral or facial edema, and respiratory distress. Patients should be educated to recognize early signs of a systemic reaction and seek immediate medical attention if symptoms such as throat swelling, difficulty breathing, or widespread hives occur.

Oralair is contraindicated in individuals with a known hypersensitivity to the product or any of its excipients, those with severe uncontrolled asthma, and patients experiencing an acute severe allergic episode at the time of dosing. Caution is also advised for pregnant or breastfeeding women until safety is clarified by a healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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