Product image of Oralair (Allergen Extract From Pollen Of Dactylis Glomerata, Anthoxanthum Odoratum, Lolium Perenne, Poa Prate) supplied by GNH India

Oralair

Active Ingredient:
Allergen Extract From Pollen Of Dactylis Glomerata, Anthoxanthum Odoratum, Lolium Perenne, Poa Prate
Origin:
EU

Oralair (Allergen Extract From Pollen Of Dactylis Glomerata, Anthoxanthum Odoratum, Lolium Perenne, Poa Prate)

Allergen Extract From Pollen Of Dactylis Glomerata, Anthoxanthum Odoratum, Lolium Perenne, Poa Prate, the active ingredient in Oralair, is a allergen immunotherapy presented as a sublingual tablet for sublingual use. It treats seasonal allergic rhinitis (hay fever) and allergic conjunctivitis caused by grass pollen in patients who experience these seasonal symptoms.
GNH India supplies Oralair as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Stallergenes

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Indications & Clinical Uses

Oralair is an allergen immunotherapy that targets grass‑pollen‑induced allergic disease.

  • Seasonal allergic rhinitis (hay fever): reduces nasal congestion, sneezing, itching and runny nose caused by grass pollen.
  • Allergic conjunctivitis due to grass pollen: alleviates eye itching, redness, tearing and swelling.
  • Grass‑pollen‑induced rhinoconjunctivitis: provides long‑term symptom control by inducing immune tolerance.

How It Works

  • Repeated sublingual exposure to the grass‑pollen allergen extract in Oralair shifts the immune response from a Th2‑dominant profile toward a regulatory/Th1 profile, increasing allergen‑specific IgG4 while decreasing IgE production. This immunomodulation reduces mast‑cell activation and downstream allergic inflammation, leading to clinical tolerance of grass pollen exposure.

Side Effects

Oralair may cause local and systemic reactions after sublingual administration.

Common Side Effects

  • Oral itching or mild throat irritation.
  • Mild ear or palate pruritus.
  • Transient gastrointestinal discomfort.
  • Local swelling of the mouth or tongue.
  • Mild headache.
  • Temporary increase in nasal congestion.

Serious or Rare Side Effects

  • Anaphylaxis or severe systemic allergic reaction.
  • Angioedema involving the face, lips or airway.
  • Respiratory distress or bronchospasm.
  • Severe urticaria or widespread rash.
  • Cardiovascular collapse.
  • Persistent vomiting or severe gastrointestinal upset.

Precautions & Warnings

Before initiating Oralair, patients should be evaluated for suitability and instructed on proper administration.

  • Medical assessment: confirm diagnosis of grass‑pollen allergy and rule out uncontrolled asthma.
  • First dose supervision: administer the initial dose under medical observation.
  • Concomitant immunotherapy: avoid using other allergen extracts simultaneously.
  • Pregnancy and lactation: safety not established; discuss risks with a healthcare professional.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Oralair may interact with other medications that influence allergic responses or immune modulation.

Major Interactions (Avoid)

  • Concurrent use of other sublingual allergen extracts: risk of additive allergic reactions.
  • Beta‑blockers: may interfere with emergency treatment of anaphylaxis.
  • ACE inhibitors: may increase risk of angioedema.

Moderate Interactions (Monitor Closely)

  • Systemic corticosteroids: may reduce the effectiveness of immunotherapy.
  • Immunosuppressive agents: could diminish tolerance development.
  • Antihistamines: may mask early local reactions, requiring careful monitoring.

Frequently Asked Questions

Oralair is prescribed for patients with seasonal allergic rhinitis (hay fever) and allergic conjunctivitis that are triggered by grass pollen. By delivering a standardized grass‑pollen extract sublingually, it helps reduce nasal and ocular symptoms associated with these seasonal allergies.

The extract in Oralair repeatedly exposes the immune system to grass‑pollen proteins under the tongue. This exposure promotes a shift from a Th2‑dominant allergic response toward a regulatory/Th1 response, increasing IgG4 antibodies and decreasing IgE production, which together diminish allergic inflammation and improve tolerance to grass pollen.

The dosing regimen for Oralair is individualized by the prescribing clinician based on the patient’s age, severity of allergy, and response to therapy. The prescriber determines the starting dose, titration schedule, and maintenance dose, and patients should follow the specific instructions provided by their healthcare professional.

Safety data for Oralair in pregnancy and lactation are limited, and the product is not classified for use in these populations. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their physician before starting treatment.

To request Oralair, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Oralair is a sublingual immunotherapy tablet, offering a non‑injectable alternative to traditional subcutaneous allergy shots. Compared with antihistamines, it targets the underlying immune response rather than just symptom relief, and it provides long‑term tolerance after a course of treatment, whereas antihistamines require continuous use.

Oralair tablets should be stored at ambient temperature, preferably below 25 °C. Keep them in the original blister pack, protect from moisture and direct sunlight, and ensure the container is tightly closed to maintain product stability throughout its shelf life.

Oralair is taken sublingually. The tablet is placed under the tongue and allowed to dissolve completely without swallowing, chewing, or drinking for a few minutes. Patients should avoid eating or drinking for at least 5 minutes after administration to ensure optimal absorption.

The most serious risks include systemic allergic reactions such as anaphylaxis, angioedema, and severe bronchospasm. Patients should be monitored after the first dose and instructed to seek immediate medical attention if they experience difficulty breathing, swelling of the face or throat, or any signs of a severe reaction.

Oralair is contraindicated in individuals with a history of severe systemic reactions to grass‑pollen extracts, uncontrolled asthma, or those currently receiving other allergen immunotherapy products. Patients with known hypersensitivity to any component of the tablet should also avoid its use.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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