Product image of Oralair (Allergen Extract From Pollen Of Dactylis Glomerata, Anthoxanthum Odoratum, Lolium Perenne, Poa Prate) supplied by GNH India

Oralair

Active Ingredient:
Allergen Extract From Pollen Of Dactylis Glomerata, Anthoxanthum Odoratum, Lolium Perenne, Poa Prate
Origin:
EU

Oralair (Allergen Extract From Pollen Of Dactylis Glomerata, Anthoxanthum Odoratum, Lolium Perenne, Poa Prate)

Grass pollen allergen extract, the active ingredient in Oralair, is a allergen immunotherapy presented as a sublingual tablet for sublingual use. It is indicated for the prevention and reduction of symptoms of seasonal allergic rhinitis caused by grass pollen in patients with confirmed sensitivity.

GNH India supplies Oralair as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory‑compliant distribution across multiple regions, ensuring product integrity from manufacturing to end‑user.

Manufacturer / TM Owner

Stallergenes

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Indications & Clinical Uses

  • Oralair is used in allergen immunotherapy to modify the immune response to grass pollen allergens.
  • Seasonal allergic rhinitis (grass pollen): reduces frequency and intensity of nasal symptoms.
  • Allergic rhinoconjunctivitis (grass pollen): improves both nasal and ocular symptoms.
  • Grass pollen allergy in children (5‑17 years): provides long‑term tolerance when administered as prescribed.

How It Works

  • Oralair delivers a standardized grass pollen allergen extract sublingually, promoting repeated exposure to specific allergens. This exposure shifts the immune response from an IgE‑mediated pathway toward IgG4 production and activates regulatory T‑cells, leading to immune tolerance and reduced hypersensitivity to grass pollen.

Side Effects

Oralair may cause local and systemic adverse reactions, most of which are mild and transient.

Common Side Effects

  • Oral itching or tingling.
  • Throat irritation or mild swelling.
  • Mild gastrointestinal discomfort.
  • Headache.
  • Transient local edema.
  • Mild urticaria.

Serious or Rare Side Effects

  • Anaphylaxis or severe systemic allergic reaction.
  • Severe oral or facial swelling that impairs breathing.
  • Respiratory distress or bronchospasm.
  • Angioedema.
  • Severe urticaria with systemic involvement.

Precautions & Warnings

  • Before prescribing Oralair, clinicians should consider the following precautions to ensure safe use.
  • Assess patient history: confirm documented grass pollen allergy before initiation.
  • Avoid use in uncontrolled asthma: ensure asthma is well‑controlled prior to treatment.
  • Monitor early treatment phase: observe for local reactions during the first week of therapy.
  • Do not combine with other allergen immunotherapies unless directed by a specialist.
  • Pregnancy and lactation: use only if the potential benefit outweighs the unknown risk.
  • Store at ambient temperature below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Oralair can interact with certain medications and other immunotherapies; awareness of these interactions helps manage risk.

Major Interactions (Avoid)

  • Beta‑blockers: may reduce the effectiveness of emergency epinephrine in case of severe allergic reaction.
  • ACE inhibitors: increase the risk of angioedema when combined with allergen exposure.

Moderate Interactions (Monitor Closely)

  • Systemic antihistamines: may mask early signs of local allergic reactions.
  • Immunosuppressants (e.g., methotrexate, azathioprine): may diminish the therapeutic response to immunotherapy.
  • Oral corticosteroids: can suppress the intended immune modulation of the treatment.

Frequently Asked Questions

Oralair is a sublingual tablet containing a standardized grass pollen allergen extract. It is prescribed to prevent and lessen the symptoms of seasonal allergic rhinitis and allergic rhinoconjunctivitis caused by grass pollen in patients who have demonstrated sensitivity to these pollens.

The extract is administered under the tongue, providing repeated low‑dose exposure to grass pollen proteins. This exposure gradually shifts the immune system from an IgE‑driven allergic response toward a protective IgG4 response and activates regulatory T‑cells, fostering long‑term tolerance to the allergen.

The dosing schedule for Oralair is individualized by the prescribing clinician. Typically, a titration phase is followed by a maintenance dose, but the exact regimen, including the number of tablets and duration, must be set by the healthcare professional based on the patient’s age, severity of allergy, and response to therapy.

Safety data for Oralair in pregnancy and lactation are limited. It should only be used if the potential therapeutic benefit justifies any potential risk to the fetus or infant, and the decision should be made in consultation with a qualified healthcare provider.

To place an order, submit an enquiry on the Oralair product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any temperature requirements), and the necessary import documentation.

Oralair is a sublingual tablet, offering a non‑injectable alternative to subcutaneous allergen immunotherapy (SCIT). It can be self‑administered at home after the initial supervised dose, which may improve convenience and adherence. However, SCIT may be preferred for certain allergens or when a faster desensitisation is required.

Oralair tablets should be stored at ambient temperature below 25 °C, in their original packaging, and protected from moisture and direct sunlight. Do not refrigerate or freeze the product. Keep the tablets out of reach of children and avoid exposing them to excessive heat.

The tablet is placed under the tongue and allowed to dissolve completely without chewing or swallowing water. The patient should keep the tablet in place for several minutes, as instructed by the prescriber, to ensure optimal absorption through the sublingual mucosa.

The most serious risks include systemic allergic reactions such as anaphylaxis, severe oral or facial swelling that can compromise breathing, and respiratory distress or bronchospasm. Patients should be educated to recognize early signs of these reactions and seek immediate medical attention if they occur.

Oralair is contraindicated in individuals with a known hypersensitivity to any component of the tablet, those with severe uncontrolled asthma, or patients who have experienced a severe systemic reaction to a previous grass pollen immunotherapy. It should also be avoided in patients taking medications that significantly increase the risk of anaphylaxis without appropriate medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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