Product image of Oralair (Allergen Extract From Pollen Of Dactylis Glomerata, Anthoxanthum Odoratum, Lolium Perenne, Poa Prate) supplied by GNH India

Oralair

Active Ingredient:
Allergen Extract From Pollen Of Dactylis Glomerata, Anthoxanthum Odoratum, Lolium Perenne, Poa Prate
Origin:
EU

Oralair (Allergen Extract From Pollen Of Dactylis Glomerata, Anthoxanthum Odoratum, Lolium Perenne, Poa Prate)

Allergen Extract From Pollen Of Dactylis Glomerata, Anthoxanthum Odoratum, Lolium Perenne, Poa Prate, the active ingredient in Oralair, is a allergen immunotherapy presented as a sublingual tablet for oral use. It is used to treat grass‑pollen induced allergic rhinitis and related rhinoconjunctivitis in adults and children.
GNH India supplies Oralair as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Stallergenes

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Indications & Clinical Uses

Oralair is an allergen immunotherapy that targets grass‑pollen driven allergic airway disease.

  • Grass pollen allergic rhinitis: reduces nasal congestion, sneezing and itching during the grass season.
  • Seasonal allergic rhinoconjunctivitis: alleviates both nasal and ocular symptoms caused by grass pollen exposure.
  • Pediatric grass pollen allergy: provides long‑term symptom control in children as part of a disease‑modifying regimen.

How It Works

  • Oralair contains standardized extracts of grass‑pollen allergens that are administered sublingually. Repeated exposure induces immune tolerance by shifting the T‑cell response from a Th2‑dominant profile toward regulatory T‑cells, increasing allergen‑specific IgG4 and reducing IgE‑mediated mast cell activation, thereby diminishing the clinical allergic response upon natural pollen exposure.

Side Effects

Adverse reactions are generally related to local exposure of the oral mucosa and systemic immune activation.

Common Side Effects

  • Oral itching or tingling: mild discomfort in the mouth after dosing.
  • Throat irritation: transient soreness or scratchy sensation.
  • Ear pruritus: itching in the ears or around the jaw.
  • Mild gastrointestinal upset: nausea or abdominal discomfort.
  • Local swelling of the tongue or lips: transient and self‑limiting.

Serious or Rare Side Effects

  • Anaphylaxis: severe, life‑threatening allergic reaction requiring emergency care.
  • Systemic allergic reaction: widespread urticaria, angioedema or bronchospasm.
  • Asthma exacerbation: worsening of underlying asthma symptoms.
  • Laryngeal edema: swelling of the throat that may affect breathing.
  • Severe gastrointestinal symptoms: persistent vomiting or diarrhea.

Precautions & Warnings

Before initiating therapy, patients should be evaluated for contraindications and instructed on proper use.

  • Contraindication: severe uncontrolled asthma: Oralair should not be started in patients with recent severe asthma attacks.
  • Medical supervision: first dose must be taken under physician observation to monitor for systemic reactions.
  • Pregnancy and lactation: use only if clearly needed; discuss risks with a healthcare provider.
  • Concomitant medications: antihistamines may mask early signs of an allergic reaction; consider timing.
  • Storage: Store at ambient temperature below 25°C: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Oralair may interact with medications that influence immune response or mask early allergic symptoms.

Major Interactions (Avoid)

  • Beta‑blockers: may reduce effectiveness of emergency epinephrine in anaphylaxis.
  • ACE inhibitors: can exacerbate angioedema risk when combined with allergic reactions.

Moderate Interactions (Monitor Closely)

  • Antihistamines: may conceal early oral itching, delaying detection of a reaction.
  • Corticosteroids: may alter immune tolerance development, requiring dose adjustment.
  • Immunosuppressants: could affect the immunomodulatory effect of the allergen extract.

Frequently Asked Questions

Oralair is a sublingual allergen immunotherapy tablet indicated for the treatment of grass‑pollen induced allergic rhinitis and rhinoconjunctivitis in adults and children. It works by gradually desensitizing the immune system to grass pollen, reducing seasonal symptoms such as sneezing, nasal congestion, and itchy eyes.

The allergen extract contains standardized proteins from several grass species. When taken regularly under the tongue, it promotes the development of regulatory T‑cells and allergen‑specific IgG4 antibodies, shifting the immune response away from an IgE‑driven allergic pathway and thereby decreasing the severity of allergic reactions upon natural pollen exposure.

The dosing regimen for Oralair is individualized by the prescribing clinician based on the patient’s age, severity of allergy, and response to therapy. The prescriber determines the starting dose, titration schedule, and maintenance dose, which are typically administered once daily under the tongue during the pre‑seasonal period.

Safety data for Oralair in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant. Healthcare providers should discuss individual circumstances and consider alternative management strategies when appropriate.

To request Oralair, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide. After submission, the sales team will verify trade or institutional credentials and respond with pricing, availability, shipping details (including any cold‑chain requirements) and required import documentation.

Oralair is a sublingual tablet that offers a non‑injectable route compared with traditional subcutaneous allergy shots. It provides a convenient at‑home administration schedule and has a favorable safety profile for most patients, though both modalities aim to achieve long‑term immune tolerance. Choice depends on patient preference, medical history and physician recommendation.

Oralair tablets should be stored at ambient temperature below 25 °C, in the original packaging to protect from moisture and direct sunlight. Do not refrigerate or freeze the product. Keep the tablets out of reach of children and avoid exposing them to extreme temperatures.

Oralair is taken as a single tablet placed under the tongue, where it is allowed to dissolve completely without swallowing. Patients should remain upright for at least 30 minutes after dosing and avoid eating or drinking during that time to ensure optimal absorption of the allergen extract.

The most serious risks include systemic allergic reactions such as anaphylaxis, severe bronchospasm, or laryngeal edema. These events are rare but require immediate medical attention. Patients should be educated on recognizing early signs of a severe reaction and have access to emergency medication, such as epinephrine, if prescribed.

Oralair is contraindicated in individuals with a history of severe uncontrolled asthma, previous anaphylactic reaction to grass pollen extracts, or those receiving beta‑blocker therapy that cannot be discontinued. It should also be avoided in patients with known hypersensitivity to any component of the tablet.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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