Oralair (Allergen Extract From Pollen Of Dactylis Glomerata, Anthoxanthum Odoratum, Lolium Perenne, Poa Prate)

Oralair is an allergen immunotherapy tablet that targets the immune response to grass‑pollen allergens. It is used to modify disease activity in seasonal allergic conditions.

• Grass‑pollen allergic rhinitis: reduces nasal congestion, sneezing and itching.
• Grass‑pollen allergic conjunctivitis: alleviates eye redness, tearing and irritation.
• Combined allergic rhinoconjunctivitis: improves overall symptom control during the grass pollen season.

• Oralair delivers standardized grass‑pollen allergen extracts to the oral mucosa, where they are taken up by antigen‑presenting cells. Repeated exposure induces regulatory T‑cell responses and a shift from IgE‑mediated to IgG4‑mediated immunity, promoting long‑term tolerance and reducing the clinical reactivity to grass pollen.

Common Side Effects

• Oral itching or tingling: mild irritation of the mouth and throat.
• Throat irritation: transient soreness after tablet placement.
• Ear pruritus: itching in the ear canal.
• Nasal congestion: mild blockage of nasal passages.
• Cough: brief coughing episodes after administration.
• Mild gastrointestinal discomfort: occasional stomach upset.

Serious or Rare Side Effects

• Anaphylaxis: severe, potentially life‑threatening allergic reaction.
• Systemic allergic reaction: widespread hives, swelling or respiratory difficulty.
• Severe asthma exacerbation: worsening of asthma symptoms.
• Angioedema: rapid swelling of lips, tongue or face.
• Cardiovascular symptoms: dizziness, hypotension or fainting.
• Persistent gastrointestinal bleeding: rare but serious GI upset.

Before initiating Oralair, patients should be evaluated for appropriate diagnosis and suitability.

• Medical evaluation: confirm grass‑pollen allergy and rule out contraindications.
• Age restriction: not recommended for children younger than five years.
• Asthma control: ensure asthma is well‑controlled before use.
• Pregnancy and lactation: discuss risks with a healthcare professional.
• Concomitant immunotherapy: avoid simultaneous use of other allergen immunotherapies.
• Store at room temperature: keep in the original container, protect from moisture and light.

Oralair may interact with other medicines that affect allergic responses.

Major Interactions (Avoid)

• Beta‑blockers: can mask symptoms of anaphylaxis and complicate emergency treatment.
• ACE inhibitors: may increase the risk of severe allergic reactions.

Moderate Interactions (Monitor Closely)

• Antihistamines: may reduce local side effects but do not eliminate the need for monitoring.
• Systemic corticosteroids: could alter immune tolerance development.
• Other allergen immunotherapies: combined use may raise the chance of systemic reactions.