Product image of Oralair (Allergen Extract From Pollen Of Dactylis Glomerata, Anthoxanthum Odoratum, Lolium Perenne, Poa Prate) supplied by GNH India

Oralair

Active Ingredient:
Allergen Extract From Pollen Of Dactylis Glomerata, Anthoxanthum Odoratum, Lolium Perenne, Poa Prate
Origin:
EU

Oralair (Allergen Extract From Pollen Of Dactylis Glomerata, Anthoxanthum Odoratum, Lolium Perenne, Poa Prate)

Allergen Extract From Pollen Of Dactylis Glomerata, Anthoxanthum Odoratum, Lolium Perenne, Poa Prate, the active ingredient in Oralair, is a allergen immunotherapy presented as a sublingual tablet for sublingual use. It is indicated for the treatment of grass‑pollen‑induced allergic rhinitis and related seasonal symptoms in adolescents and adults.

GNH India supplies Oralair as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to EU quality standards and provides regulatory‑approved batches for global distribution.

Manufacturer / TM Owner

Stallergenes

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Indications & Clinical Uses

Oralair is used in allergen immunotherapy to modify the immune response to grass pollen exposure.

  • Grass pollen allergic rhinitis: reduces nasal congestion, sneezing and itching during the grass season.
  • Seasonal allergic rhinoconjunctivitis due to grass pollen: improves ocular symptoms and overall quality of life.
  • Grass pollen‑induced asthma (adjunct): may lessen reliance on rescue medication in sensitised patients.

How It Works

  • Oralair delivers standardized grass pollen allergen extracts to the oral mucosa, where sublingual exposure promotes the development of regulatory T‑cells and shifts the immune response from a Th2‑dominant profile toward tolerance. This process increases allergen‑specific IgG4 blocking antibodies and reduces IgE‑mediated mast cell activation, thereby decreasing the clinical expression of allergic inflammation.

Side Effects

Common and serious adverse reactions have been reported with sublingual grass pollen immunotherapy.

Common Side Effects

  • Oral itching or mild irritation.
  • Swelling of the lips or tongue.
  • Mild throat discomfort.
  • Transient gastrointestinal upset.
  • Localized rash at the site of administration.

Serious or Rare Side Effects

  • Anaphylaxis or severe systemic allergic reaction.
  • Angioedema involving the face or airway.
  • Severe bronchospasm requiring emergency treatment.
  • Persistent eosinophilic esophagitis.
  • Cardiovascular collapse (very rare).

Precautions & Warnings

Before prescribing Oralair, clinicians should consider the following precautions.

  • Contraindication: active systemic allergic reaction to the tablet or any component.
  • Caution: use in patients with uncontrolled asthma; ensure asthma is stable before initiation.
  • Monitoring: observe patients for at least 30 minutes after the first dose for signs of systemic reaction.
  • Pregnancy: safety not established; weigh potential benefits against unknown risks.
  • Breastfeeding: limited data; consider risk‑benefit assessment.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Oralair may interact with other medications or substances that affect immune response or increase the risk of allergic reactions.

Major Interactions (Avoid)

  • Beta‑blockers: may blunt response to anaphylaxis treatment.
  • ACE inhibitors: can exacerbate angioedema risk.
  • Immunosuppressants: may reduce efficacy of immunotherapy.

Moderate Interactions (Monitor Closely)

  • Antihistamines: may mask early signs of systemic reaction.
  • NSAIDs: can increase gastrointestinal irritation.
  • Alcohol: may enhance oral mucosal irritation.

Frequently Asked Questions

Oralair is a prescription sublingual tablet that provides a standardized grass‑pollen allergen extract for allergen immunotherapy. It is used to treat grass‑pollen‑induced allergic rhinitis and related seasonal rhinoconjunctivitis, helping to reduce nasal and ocular symptoms during the grass season.

The extract is placed under the tongue, where it contacts oral mucosal immune cells. Repeated low‑dose exposure promotes regulatory T‑cell development and increases allergen‑specific IgG4 antibodies, shifting the immune response away from an IgE‑driven allergic pathway and fostering long‑term tolerance to grass pollen.

The dosing regimen for Oralair is individualized by the prescribing clinician based on the patient’s age, severity of symptoms, and treatment protocol. The prescriber determines the starting dose, titration schedule, and maintenance dose, which are not standardized across all patients.

Safety data for Oralair in pregnancy and lactation are limited. The product is classified as having an unknown pregnancy category, so clinicians must weigh potential benefits against possible risks. Breastfeeding mothers should consider the lack of definitive safety information and discuss options with their healthcare provider.

To request Oralair, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide. After the enquiry, the sales team will verify institutional credentials, provide pricing, availability, shipping details (including any cold‑chain requirements), and assist with import documentation.

Oralair is a sublingual tablet, offering the convenience of at‑home administration compared with subcutaneous immunotherapy (SCIT), which requires clinic visits for injections. Compared with other SLIT tablets such as Grastek, Oralair contains a broader mix of grass species and follows a distinct dosing schedule, but both aim to achieve long‑term tolerance.

Oralair tablets should be stored at ambient temperature, preferably below 25 °C. Keep them in the original blister pack, protect from moisture, heat and direct sunlight. Do not refrigerate or freeze the tablets, and ensure the container is tightly closed when not in use.

The tablet is placed under the tongue and allowed to dissolve completely without chewing or swallowing immediately. Patients should remain upright for at least 30 minutes after the dose and avoid eating or drinking during that time. The first dose is usually taken in a medical setting for observation.

The most serious adverse events are systemic allergic reactions, including anaphylaxis, angioedema, and severe bronchospasm. These reactions can be life‑threatening and require immediate medical attention. Patients should be educated to recognize early signs and have emergency medication, such as epinephrine, readily available if prescribed.

Oralair is contraindicated in individuals with a known hypersensitivity to any component of the tablet or who are experiencing an active systemic allergic reaction. Patients with uncontrolled asthma, severe cardiovascular disease, or those taking medications that increase the risk of angioedema should be evaluated carefully before initiation.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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