Oralair (Allergen Extract From Pollen Of Dactylis Glomerata, Anthoxanthum Odoratum, Lolium Perenne, Poa Prate)

Oralair is an allergen immunotherapy used to modify the immune response to grass pollen, helping to reduce allergic disease burden.

• Seasonal allergic rhinitis (hay fever): reduces nasal symptoms and the need for rescue medication.
• Allergic conjunctivitis: alleviates eye itching, redness and tearing associated with grass pollen exposure.
• Grass‑pollen‑triggered mild asthma: may improve symptom control when used as part of a comprehensive allergy management plan.

• Oralair contains standardized grass‑pollen extracts that are administered sublingually to induce immune tolerance. Repeated exposure promotes a shift from a Th2‑dominant response toward regulatory T‑cell activity, increasing allergen‑specific IgG4 and reducing IgE‑mediated mast cell activation, thereby diminishing allergic inflammation upon natural pollen exposure.

Oralair may cause local and systemic reactions, most of which are mild and transient.

Common Side Effects

• Oral itching or tingling: mild discomfort in the mouth after administration.
• Throat irritation: transient soreness or scratchy sensation.
• Ear pruritus: itching in the ears.
• Mild gastrointestinal upset: nausea or abdominal discomfort.
• Local swelling: mild swelling of the oral mucosa.
• Sneezing or mild nasal congestion.

Serious or Rare Side Effects

• Anaphylaxis: severe, potentially life‑threatening allergic reaction.
• Systemic allergic reaction: widespread hives, angioedema, or respiratory distress.
• Asthma exacerbation: worsening of asthma symptoms.
• Severe oral mucosal edema: pronounced swelling that may impair breathing.
• Urticaria: widespread hives.
• Cardiovascular symptoms: hypotension or tachycardia associated with severe reactions.

Before initiating Oralair, patients should be evaluated for suitability and monitored for adverse reactions.

• Contraindication: severe uncontrolled asthma: avoid use in patients with recent exacerbations.
• History of severe allergic reactions: assess risk before starting therapy.
• Medical supervision: first dose should be administered under physician observation.
• Interaction with other allergen extracts: avoid simultaneous use of different sublingual immunotherapies.
• Pregnancy and breastfeeding: discuss potential risks with a healthcare professional.
• Store at room temperature: keep in the original packaging, protect from moisture and direct sunlight.

Oralair may interact with other medications or therapies, influencing safety or efficacy.

Major Interactions (Avoid)

• Beta‑blockers: may mask symptoms of anaphylaxis and complicate emergency treatment.
• Immunosuppressive agents: can reduce the effectiveness of allergen immunotherapy.
• Concurrent sublingual immunotherapy with different extracts: increased risk of severe local or systemic reactions.

Moderate Interactions (Monitor Closely)

• Antihistamines: may mask early signs of an allergic reaction.
• Systemic corticosteroids: may alter immune response to the extract.
• Live vaccines: consider timing to avoid overlapping immune activation.
• ACE inhibitors: monitor for angioedema, though risk is low.
• NSAIDs: watch for enhanced gastrointestinal irritation.