Product image of Orbenin (Cloxacillin) supplied by GNH India

Orbenin

Active Ingredient:
Cloxacillin
Origin:
EU

Orbenin (Cloxacillin)

Cloxacillin, the active ingredient in Orbenin, is a beta‑lactam antibiotic presented as a strength/form for oral use. It treats infections caused by penicillin‑resistant staphylococci in adults and children. GNH India supplies Orbenin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals and pharmacies worldwide.

GNH India supplies Orbenin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals and pharmacies worldwide.

Manufacturer / TM Owner

Laboratorio Reig Jofre, S.A.

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Indications & Clinical Uses

Orbenin is a beta‑lactam antibiotic that targets bacterial infections of the skin and soft tissues.

  • Cellulitis: Reduces bacterial load and promotes healing of inflamed skin.
  • Impetigo: Clears Staphylococcus‑driven lesions and prevents spread.
  • Osteomyelitis (adjunct therapy): Assists in eradicating resistant staphylococcal infection in bone tissue.
  • Septic arthritis: Contributes to bacterial clearance in joint infections.
  • Surgical prophylaxis: Provides coverage against penicillin‑resistant staphylococci during operative procedures.

How It Works

  • Cloxacillin inhibits bacterial cell‑wall synthesis by binding irreversibly to penicillin‑binding proteins, especially PBP‑2a, which blocks the cross‑linking of peptidoglycan strands. This action weakens the bacterial wall, leading to osmotic lysis and death of susceptible gram‑positive organisms, particularly penicillin‑resistant Staphylococcus aureus.

Side Effects

Cloxacillin may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Nausea
  • Diarrhea
  • Rash
  • Elevated liver enzymes
  • Headache

Serious or Rare Side Effects

  • Anaphylaxis
  • Stevens‑Johnson syndrome
  • Hemolytic anemia
  • Severe neutropenia
  • Acute interstitial nephritis

Precautions & Warnings

Before using Orbenin, consider the following safety measures:

  • Allergy assessment: Check the risk of beta‑beta beta beta beta beta beta beta beta beta beta beta beta beta beta beta beta beta beta beta ... 
  • Liver function monitoring: 
  • Renal treatment ... 
  • Drug interaction review ... 
  • Pregnancy ... 
  • Store at room temperature : keep the product in the original pack and protect from moist the ... 

Avoid Interactions

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Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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