Product image of Orencia (Abatacept) supplied by GNH India

Orencia

Active Ingredient:
Abatacept
Origin:
EU

Orencia (Abatacept)

Abatacept, the active ingredient in Orencia, is an immunomodulator presented as an injection for intravenous use. It treats rheumatoid arthritis, juvenile idiopathic arthritis, and psoriatic arthritis in adult and pediatric patients. GNH India supplies Orencia as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals and pharmacies worldwide.

GNH India supplies Orencia as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals and pharmacies worldwide.

Manufacturer / TM Owner

Bristol-Myers Squibb Pharma Eeig

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Indications & Clinical Uses

Orencia is a biologic disease‑modifying antirheumatic drug that targets immune‑driven joint disease.

  • Rheumatoid arthritis: reduces joint inflammation and slows structural damage.
  • Juvenile idiopathic arthritis: improves joint function and decreases disease activity.
  • Psoriatic arthritis: alleviates skin and joint symptoms and limits progression.

How It Works

  • Abatacept is a fusion protein that combines the extracellular domain of cytotoxic T‑lymphocyte‑associated antigen‑4 (CTLA‑4) with the Fc portion of IgG1. It binds to CD80 and CD86 on antigen‑presenting cells, blocking the CD28‑mediated costimulatory signal required for full T‑cell activation, thereby modulating the immune response.

Side Effects

Adverse reactions to abatacept may vary in frequency and severity.

Common Side Effects

  • Upper respiratory tract infection
  • Headache
  • Nausea
  • Hypertension
  • Infusion‑related reactions

Serious or Rare Side Effects

  • Severe infections (e.g., tuberculosis)
  • Malignancies
  • Autoimmune disorders
  • Progressive multifocal leukoencephalopathy (PML)
  • Anaphylaxis

Precautions & Warnings

When using Orencia, clinicians should consider several safety measures.

  • Infection risk: assess for active infections before starting therapy.
  • Vaccination: avoid live vaccines during treatment.
  • Monitoring: conduct regular laboratory tests to track blood counts and liver function.
  • Pregnancy: use only if the potential benefit justifies the potential risk.
  • Breastfeeding: weigh benefits against possible drug exposure to the infant.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Abatacept may interact with other medications, requiring careful management.

Major Interactions (Avoid)

  • Live vaccines: may cause severe infection.
  • Strong immunosuppressants: increase risk of serious infections.

Moderate Interactions (Monitor Closely)

  • Antiviral agents: may alter immune response.
  • Corticines [sic] **
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Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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