Product image of Orfiril Retard (Sodium Valproate) supplied by GNH India

Orfiril Retard

Active Ingredient:
Sodium Valproate
Origin:
EU

Orfiril Retard (Sodium Valproate)

Sodium Valproate, the active ingredient in Orfiril Retard, is an anticonvulsant presented as an extended‑release tablet for oral use. It treats generalized and focal seizures, stabilises mood in bipolar disorder and is used for migraine prophylaxis in adults. GNH India supplies Orfiril Retard as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

GNH India supplies Orfiril Retard as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Desitin Arzneimittel Gmbh

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Indications & Clinical Uses

Orfiril Retard is an antiepileptic medication that acts on neuronal excitability in several neurological and psychiatric conditions.

  • Epilepsy: Reduces the frequency and severity of generalized and focal seizures.
  • Bipolar disorder: Provides mood stabilization and helps prevent manic episodes.
  • Migraine prophylaxis: Decreases the number of migraine attacks when used as preventive therapy.

How It Works

  • Sodium valproate increases gamma‑aminobutyric acid (GGABA) concentrations in the brain by inhibiting its degradation and enhances GABA‑mediated neuronal inhibition. It also blocks voltage‑gated sodium channels, stabilising neuronal membranes and reducing the rapid firing of neurons that underlies seizure activity and mood dysregulation.

Side Effects

Adverse reactions to Orfiril Retard vary in frequency and severity.

Common Side Effects

  • Nausea and vomiting
  • Tremor
  • Weight gain
  • Hair loss
  • Drowsiness
  • Elevated liver enzymes

Serious or Rare Side Effects

  • Severe liver injury
  • Pancreatitis
  • Thrombocytopenia
  • Hyperammonemia
  • Stevens‑Johnson syndrome
  • Fatal brain edema

Precautions & Warnings

When prescribing Orfiril Retard, clinicians should consider several safety aspects.

  • Monitor liver function: Regular blood tests are required to detect hepatotoxicity.
  • Assess blood counts: Periodic complete‑blood‑count monitoring helps identify thrombocytopenia.
  • Evaluate pancreatic enzymes: Check amylase and lipase if abdominal symptoms arise.
  • Review psychiatric history: Monitor for mood changes or depressive symptoms.
  • Avoid use in pregnancy: Contra‑indicated due to teratogenic risk (Category X).
  • Store at below 25°C: keep in the original packaging, protect from moisture and light.

Avoid Interactions

Orfiril Retard can affect the pharmacokinetics of several co‑administered medicines.

Major Interactions (Avoid)

  • Carbamazepine: Increases valproate clearance, reducing efficacy.
  • Phenytoin: Reduces valproate plasma levels and may precipitate seizures.
  • Rifampicin: Strong enzyme inducer that markedly lowers valproate concentrations.

Moderate Interactions (Monitor Closely)

  • Warfarin: Valproate may enhance anticoagulant effect, requiring INR monitoring.
  • Oral contraceptives: May reduce hormonal efficacy, increasing risk of breakthrough bleeding.
  • Lamotrigine: Valproate raises lamotrigine levels, heightening risk of skin reactions.

Frequently Asked Questions

Orfiril Retard is prescribed for the management of generalized and focal seizures in epilepsy, as a mood‑stabilising agent in bipolar disorder, and for preventive treatment of migraine headaches in adults.

Sodium valproate raises brain levels of the inhibitory neurotransmitter GABA by blocking its breakdown and also stabilises neuronal membranes by inhibiting voltage‑gated sodium channels, which together reduce excessive neuronal firing.

The dose of Orfiril Retard is individualized; a prescriber determines the appropriate strength and titration schedule based on the patient’s condition, age, weight and response to therapy.

Sodium valproate is classified as pregnancy Category X because it carries a high risk of birth defects and developmental disorders; it is contraindicated in pregnancy and generally avoided during breastfeeding.

To order, submit an enquiry on the Orfiril Retard product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and import documentation.

Compared with drugs such as carbamazepine or phenytoin, sodium valproate offers broader spectrum seizure control and mood‑stabilising benefits, but it has a higher risk of liver toxicity and teratogenicity, requiring careful monitoring.

Store tablets below 25 °C in the original container, protecting them from moisture, heat and direct light to maintain stability.

Orfiril Retard is taken orally, usually once daily with food or as directed by a healthcare professional, to maintain consistent plasma concentrations throughout the day.

Serious risks include severe liver injury, pancreatitis, thrombocytopenia, hyperammonemia, and rare skin reactions such as Stevens‑Johnson syndrome, all of which require immediate medical attention.

Patients with known hypersensitivity to sodium valproate, active liver disease, mitochondrial disorders such as POLG‑related disease, or women who are pregnant or may become pregnant should avoid using Orfiril Retard.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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