Product image of Orgametril (Lynestrenol) supplied by GNH India

Orgametril

Active Ingredient:
Lynestrenol
Origin:
EU

Orgametril (Lynestrenol)

Lynestrenol, the active ingredient in Orgametril, is a progestogen presented as a tablet for oral use. It treats contraception in women of reproductive age.
GNH India supplies Orgametril as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Organon Belgium B.V.

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Indications & Clinical Uses

Orgametril, a synthetic progestogen, is used in hormonal contraception to prevent pregnancy.

  • Contraception: prevents ovulation and pregnancy in women of reproductive age.
  • Menstrual disorder management: helps regulate menstrual bleeding and reduce dysmenorrhea.
  • Endometriosis symptom control: reduces endometrial tissue proliferation and associated pelvic pain.

How It Works

  • Lynestrenol binds to progesterone receptors in the hypothalamic‑pituitary‑ovarian axis, inhibiting the luteinizing hormone surge and thereby suppressing ovulation. It also induces changes in cervical mucus, making it less permeable to sperm, and alters the endometrial lining to render it unsuitable for implantation.

Side Effects

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Headache: tension‑type or migraine‑like pain.
  • Breast tenderness: swelling or discomfort.
  • Weight gain: modest increase in body weight.
  • Mood changes: irritability or emotional lability.
  • Irregular bleeding: spotting or breakthrough bleeding.

Serious or Rare Side Effects

  • Deep vein thrombosis: blood clot formation in deep veins.
  • Pulmonary embolism: clot migration to lung vessels.
  • Liver dysfunction: abnormal liver enzymes or jaundice.
  • Severe allergic reaction: rash, swelling, or anaphylaxis.
  • Hyperglycemia: elevated blood glucose levels.
  • Depression with suicidal ideation: severe mood disturbances requiring immediate medical attention.

Precautions & Warnings

Before prescribing Orgametril, consider the following precautions:

  • Pregnancy avoidance: do not use if pregnant; ensure effective contraception.
  • Breastfeeding: consult a healthcare professional before use while nursing.
  • Cardiovascular risk: assess history of thromboembolic disorders before prescribing.
  • Liver disease: use with caution in patients with hepatic impairment.
  • Drug interactions: review concomitant medications for potential interactions.
  • Store at ambient temperature: keep below 25°C in the original packaging, protect from moisture and light.

Avoid Interactions

Lynestrenol may interact with several medicines; review patient medication lists.

Major Interactions (Avoid)

  • Rifampicin: strong enzyme inducer that reduces progestogen levels.
  • Carbamazepine: induces metabolism, decreasing contraceptive efficacy.
  • St. John's wort: herbal inducer that may lower drug exposure.
  • Ketoconazole: potent inhibitor that can increase plasma concentrations.
  • HIV protease inhibitors: may alter hormonal balance.

Moderate Interactions (Monitor Closely)

  • Phenytoin: moderate enzyme inducer, may reduce effectiveness.
  • SSRIs (e.g., fluoxetine): can affect hormone metabolism.
  • Antihypertensives: possible additive blood pressure effects.
  • Diuretics: may influence electrolyte balance.
  • NSAIDs: may increase risk of gastrointestinal irritation.

Frequently Asked Questions

Orgametril contains lynestrenol, a synthetic progestogen used primarily as a hormonal contraceptive. It is prescribed to prevent pregnancy by inhibiting ovulation, thickening cervical mucus, and altering the endometrial lining, making it unsuitable for implantation.

Lynestrenol binds to progesterone receptors in the hypothalamic‑pituitary‑ovarian axis, suppressing the luteinizing hormone surge needed for ovulation. It also makes cervical mucus more viscous, hindering sperm passage, and transforms the uterine lining so that a fertilized egg cannot implant.

The dosage of Orgametril is determined by the prescribing healthcare professional based on the patient’s medical history and treatment plan. Patients should follow the prescriber’s instructions and not adjust the dose without medical guidance.

Orgametril is intended for use only when effective contraception is required; it should not be used during an existing pregnancy. Women who are breastfeeding should discuss use with their healthcare provider, as safety data are limited.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Orgametril’s active ingredient, lynestrenol, is a progestogen‑only option, whereas many oral contraceptives combine estrogen and progestogen. Progestogen‑only formulations are often chosen for patients who cannot take estrogen, offering similar efficacy with a different side‑effect profile.

Store Orgametril tablets at ambient temperature, preferably below 25 °C. Keep the product in its original blister pack, protect it from moisture and direct light, and ensure the container is tightly closed when not in use.

Orgametril is taken orally, usually once daily at the same time each day. The tablet should be swallowed whole with water and not chewed or crushed, unless otherwise directed by a healthcare professional.

Serious but rare risks include thromboembolic events such as deep‑vein thrombosis or pulmonary embolism, severe liver dysfunction, and allergic reactions that may lead to anaphylaxis. Patients should seek immediate medical attention if they experience symptoms like sudden chest pain, severe abdominal pain, jaundice, or swelling of the face and throat.

Orgametril is contraindicated in women who are currently pregnant, have a known or suspected estrogen‑dependent tumor, have a history of thromboembolic disorders, severe liver disease, or unexplained vaginal bleeding. Individuals with known hypersensitivity to lynestrenol or any tablet excipients should also avoid its use.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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