Product image of Orgametril (Lynestrenol) supplied by GNH India

Orgametril

Active Ingredient:
Lynestrenol
Origin:
EU

Orgametril (Lynestrenol)

Lynestrenol, the active ingredient in Orgametril, is a synthetic progestogen presented as a tablet for oral administration. It is employed in hormonal contraception and for the management of menstrual disorders, providing pregnancy prevention and cycle regulation for women of reproductive age.

GNH India supplies Orgametril as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality‑controlled manufacturing and reliable global distribution. The product complies with EU pharmaceutical standards and is available for export to multiple regions, and can be integrated into national health programs.

Manufacturer / TM Owner

Organon Belgium B.V.

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Indications & Clinical Uses

Orgametril (lynestrenol) is a progestogen used in hormonal contraception and menstrual disorder management.

  • Oral contraception: prevents ovulation and creates endometrial changes to inhibit implantation.
  • Dysmenorrhea: reduces menstrual pain by stabilizing the endometrial lining.
  • Irregular menstrual cycles: helps regulate cycle length and flow.

How It Works

  • Lynestrenol binds to progesterone receptors in the hypothalamus and pituitary, suppressing the luteinizing hormone surge and thereby inhibiting ovulation. It also induces endometrial transformation, thickens cervical mucus, and alters tubal motility, collectively preventing fertilization and implantation.

Side Effects

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Headache: tension‑type or migraine‑like pain.
  • Breast tenderness: swelling or discomfort of the breasts.
  • Spotting: irregular light bleeding between periods.

Serious or Rare Side Effects

  • Thromboembolic events: deep vein thrombosis or pulmonary embolism.
  • Severe allergic reaction: rash, swelling, or anaphylaxis.
  • Hepatic dysfunction: jaundice or abnormal liver enzymes.

Precautions & Warnings

Before initiating therapy, consider the following precautions:

  • Thrombotic risk assessment: evaluate personal or family history of clotting disorders.
  • Liver function monitoring: avoid use in patients with active hepatic disease.
  • Blood pressure check: monitor for hypertension during treatment.
  • Smoking counseling: advise cessation, especially in women over 35.
  • Pregnancy avoidance: ensure effective contraception; do not start if pregnancy is suspected.
  • Store at room temperature: keep in the original pack, protect from moisture and direct sunlight.

Avoid Interactions

Major Interactions (Avoid)

  • Concurrent hormonal contraceptives: may increase risk of hormonal excess.
  • Strong enzyme inducers (e.g., rifampicin, carbamazepine): can markedly reduce efficacy.
  • Antiepileptic drugs (e.g., phenytoin, phenobarbital): may lower plasma levels.

Moderate Interactions (Monitor Closely)

  • Antifungal agents (e.g., ketoconazole): may increase drug exposure.
  • Certain antiretrovirals (e.g., protease inhibitors): may alter metabolism and require monitoring.

Frequently Asked Questions

Orgametril contains lynestrenol, a progestogen that is used primarily for hormonal contraception to prevent pregnancy and for the management of menstrual disorders such as irregular cycles and dysmenorrhea in women of reproductive age.

Lynestrenol exerts its effect by binding to progesterone receptors, suppressing the luteinizing hormone surge, which prevents ovulation. It also induces changes in the endometrium and thickens cervical mucus, creating an environment that is unfavorable for fertilization and implantation.

The specific dose and regimen of Orgametril are determined by the prescribing healthcare professional based on the patient’s clinical needs and the intended indication. Typically, the medication is taken orally once daily as part of a cyclic schedule, but exact details must be provided by the prescriber.

Orgametril is contraindicated in pregnancy because it is intended to prevent conception. Its safety during breastfeeding has not been fully established; therefore, a healthcare provider should evaluate the risks and benefits before use in lactating women.

To order Orgametril, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request verification of trade or institutional credentials before providing pricing, availability, shipping details and any necessary import documentation.

Compared with other progestogen‑only pills such as levonorgestrel, lynestrenol offers a similar mechanism of ovulation suppression but may differ in side‑effect profiles and dosing schedules. The choice between products depends on individual patient factors, tolerance, and the prescriber’s clinical judgment.

Orgametril tablets should be stored at room temperature, below 25 °C, in the original packaging to protect them from moisture and light. Keep the container tightly closed and out of reach of children.

Orgametril is taken orally, usually as a single tablet each day. It is commonly prescribed in a cyclic regimen (e.g., 21 days of active tablets followed by a hormone‑free interval), but the exact schedule should follow the prescriber’s instructions.

The most serious risks include thromboembolic events such as deep‑vein thrombosis or pulmonary embolism, severe allergic reactions, and hepatic dysfunction. Patients should be monitored for signs of these conditions and seek immediate medical attention if they occur.

Orgametril should not be used by women who are pregnant, have a known hypersensitivity to lynestrenol or any tablet excipients, have active liver disease, a history of thromboembolic disorders, or who are currently using interacting medications that could reduce its effectiveness.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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