Product image of Orgametril (Lynestrenol) supplied by GNH India

Orgametril

Active Ingredient:
Lynestrenol
Origin:
EU

Orgametril (Lynestrenol)

Lynestrenol, the active ingredient in Orgametril, is a progestogen presented as a tablet for oral use. It is used as a hormonal contraceptive to prevent pregnancy in women of reproductive age.

GNH India supplies Orgametril as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Organon Polska Sp. Z O.O.

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Indications & Clinical Uses

Orgametril (lynestrenol) is a progestogenic hormonal contraceptive used to prevent pregnancy.

  • Contraception: Prevents ovulation and creates cervical mucus changes to reduce the chance of fertilisation.

How It Works

  • Lynestrenol binds to progesterone receptors in the hypothalamus and pituitary, suppressing the luteinising hormone surge and thereby inhibiting ovulation. It also induces endometrial transformation that is unsuitable for implantation and thickens cervical mucus, providing multiple barriers to conception.

Side Effects

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Headache: tension‑type or migraine‑like pain.
  • Breast tenderness: discomfort or swelling of the breasts.
  • Weight gain: modest increase in body weight.
  • Mood changes: irritability or emotional lability.
  • Irregular bleeding: spotting or breakthrough bleeding.

Serious or Rare Side Effects

  • Thromboembolic events: deep‑vein thrombosis or pulmonary embolism.
  • Hepatic dysfunction: jaundice or abnormal liver enzymes.
  • Severe allergic reaction: rash, swelling, or anaphylaxis.
  • Depression: new or worsening depressive symptoms.
  • Visual disturbances: blurred vision or ocular pain.
  • Persistent hypertension: elevated blood pressure not controlled by medication.

Precautions & Warnings

Before prescribing Orgametril, clinicians should evaluate individual risk factors and counsel patients on safe use.

  • Assess thromboembolism risk: avoid in women with a history of clotting disorders.
  • Avoid in estrogen‑dependent tumors: contraindicated for known breast or endometrial cancer.
  • Monitor blood pressure: watch for hypertension during therapy.
  • Evaluate liver function: use with caution in hepatic impairment.
  • Store at below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Lynestrenol may interact with other medicines that alter its metabolism or efficacy.

Major Interactions (Avoid)

  • Enzyme‑inducing anticonvulsants (e.g., carbamazepine, phenytoin): reduce contraceptive effectiveness.
  • Rifampicin: strong inducer that may lower plasma levels.
  • Certain antiretrovirals (e.g., efavirenz): decrease hormonal activity.

Moderate Interactions (Monitor Closely)

  • Broad‑spectrum antibiotics (e.g., tetracycline): possible modest reduction in effect.
  • Antifungals (e.g., fluconazole): may increase plasma concentration.
  • St. John’s wort: herbal inducer that could lower efficacy.

Frequently Asked Questions

Orgametril contains lynestrenol, a progestogenic agent that is prescribed as a hormonal contraceptive to prevent pregnancy in women of reproductive age. It works by inhibiting ovulation and creating cervical mucus changes that reduce the likelihood of fertilisation.

Lynestrenol binds to progesterone receptors in the brain, suppressing the luteinising hormone surge needed for ovulation. It also induces endometrial changes that are unsuitable for implantation and thickens cervical mucus, providing multiple mechanisms that together prevent conception.

The specific dose and dosing schedule of Orgametril are determined by the prescribing clinician based on the patient’s medical history and local guidelines. Patients should follow the prescriber’s instructions and not alter the regimen without medical advice.

Orgametril is intended for use as a contraceptive and should not be taken during pregnancy. If pregnancy occurs, the medication should be discontinued. Limited data are available for breastfeeding; clinicians usually advise caution and may recommend alternative methods.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Orgametril (lynestrenol) is a progestogen‑only option, whereas many combined oral contraceptives contain both estrogen and progestogen. Progestogen‑only pills are often chosen for women who cannot take estrogen due to risk factors such as hypertension or migraine with aura.

Orgametril tablets should be stored at or below 25 °C, in their original packaging, and protected from moisture and direct sunlight. This helps maintain potency and ensures the product remains stable throughout its shelf life.

Orgametril is taken orally, usually once daily at the same time each day. Patients should swallow the tablet whole with water and avoid crushing or chewing it, unless otherwise directed by a healthcare professional.

The most serious risks include venous thromboembolism, severe hepatic dysfunction, and rare allergic reactions such as anaphylaxis. Patients should seek immediate medical attention if they experience symptoms like unexplained swelling, severe abdominal pain, jaundice, or difficulty breathing.

Orgametril is contraindicated in women with a known history of thromboembolic disorders, active or past estrogen‑dependent cancers, severe liver disease, or unexplained vaginal bleeding. It should also be avoided during pregnancy and in individuals who are hypersensitive to lynestrenol or any excipients.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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