Product image of Oriens (Mizolastine) supplied by GNH India

Oriens

Active Ingredient:
Mizolastine
Origin:
EU

Oriens (Mizolastine)

Mizolastine, the active ingredient in Oriens, is a antihistamine presented as a tablet for oral use. It relieves symptoms of allergic rhinitis and chronic urticaria in adults and children.
GNH India supplies Oriens as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Galenica Sa

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Indications & Clinical Uses

Mizolastine acts on histamine H1 receptors to alleviate allergic conditions.

  • Allergic rhinitis: reduces nasal congestion, sneezing, itching and watery discharge.
  • Chronic idiopathic urticaria: diminishes the frequency and severity of hives and associated itching.
  • Seasonal allergic conjunctivitis: alleviates eye itching, redness and tearing.

How It Works

  • Mizolastine selectively blocks peripheral H1 histamine receptors, preventing histamine‑induced vasodilation and increased vascular permeability. It also exhibits mast‑cell stabilising activity, reducing the release of inflammatory mediators and thereby limiting allergic inflammation.

Side Effects

Mizolastine may cause a range of adverse reactions.

Common Side Effects

  • Drowsiness: mild to moderate sedation.
  • Headache: transient cranial discomfort.
  • Dry mouth: reduced salivation.
  • Fatigue: general tiredness.
  • Nausea: occasional stomach upset.
  • Dizziness: brief episodes of light‑headedness.

Serious or Rare Side Effects

  • Cardiac arrhythmia: irregular heart rhythm.
  • Severe allergic reaction: anaphylaxis or angioedema.
  • Hepatic dysfunction: elevated liver enzymes.
  • Leukopenia: reduced white blood cell count.
  • Seizures: rare convulsive episodes.
  • Psychosis: rare mental status changes.

Precautions & Warnings

Mizolastine should be used with attention to safety considerations.

  • Assess liver function: monitor hepatic enzymes before and during therapy.
  • Avoid operating machinery: sedation may impair alertness.
  • Use caution in renal impairment: dose adjustment may be required.
  • Limit concurrent CNS depressants: increased sedation risk.
  • Pregnancy and lactation: consult a physician before use.
  • Store at ambient temperature: keep in original container, protect from moisture.

Avoid Interactions

Mizolastine can interact with several drug classes.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors: may raise mizolastine plasma levels.
  • Alcohol: additive central nervous system depression.
  • Other antihistamines: risk of excessive sedation.

Moderate Interactions (Monitor Closely):\n- CNS depressants (e.g., benzodiazepines): monitor sedation.

  • Anticholinergic agents: may intensify dry‑mouth effect.
  • Theophylline: possible reduction in antihistamine efficacy.

Frequently Asked Questions

Oriens, containing mizolastine, is indicated for the relief of symptoms associated with allergic rhinitis and chronic idiopathic urticaria, helping to reduce nasal congestion, sneezing, itching, and the occurrence of hives.

Mizolastine works by selectively blocking peripheral H1 histamine receptors, preventing histamine‑mediated vasodilation and increased vascular permeability, and by stabilising mast cells to limit the release of inflammatory mediators.

The appropriate dose of Oriens is determined by the prescribing healthcare professional based on the patient’s age, weight, severity of symptoms, and clinical response.

Safety of mizolastine in pregnancy or lactation has not been fully established. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their physician before using Oriens.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Mizolastine is a second‑generation H1 antagonist offering effective allergy relief with a lower incidence of sedation compared with first‑generation antihistamines, while still providing a rapid onset of action.

Oriens should be stored at ambient temperature, below 25 °C, in its original packaging to protect it from moisture and light, ensuring the tablet’s stability throughout its shelf life.

Oriens is supplied as an oral tablet and is taken by mouth with or without food, as directed by the prescribing clinician.

Serious risks, though rare, include cardiac arrhythmia, severe allergic reactions such as anaphylaxis, hepatic dysfunction, leukopenia, seizures, and psychotic episodes. Patients should seek immediate medical attention if any of these occur.

Mizolastine is contraindicated in individuals with known hypersensitivity to mizolastine or any of its excipients, and should be used with caution in patients with severe hepatic impairment, uncontrolled cardiac disease, or a history of severe allergic reactions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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