Product image of Orimelan (Melatonin) supplied by GNH India

Orimelan

Active Ingredient:
Melatonin
Origin:
EU

Orimelan (Melatonin)

Melatonin, the active ingredient in Orimelan, is a naturally occurring hormone presented as an oral tablet for oral administration. It assists in regulating the sleep‑wake cycle and is used to promote sleep in adults with insomnia or other circadian rhythm disturbances.

GNH India supplies Orimelan as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The product is available over the counter in the EU and follows strict quality standards. It is manufactured under GMP conditions to ensure purity and consistency.

Manufacturer / TM Owner

Orion Corporation

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Indications & Clinical Uses

  • Orimelan (melatonin) is used to address sleep‑related conditions by influencing the body's circadian signaling pathways.
  • Insomnia: helps initiate and maintain sleep in adults with difficulty falling asleep.
  • Jet lag: reduces the time needed to adjust to new time zones after travel.
  • Shift work disorder: improves sleep quality for individuals working non‑standard hours.

How It Works

  • Melatonin acts as an agonist at the MT1 and MT2 receptors in the suprachiasmatic nucleus of the hypothalamus. Binding these G‑protein‑coupled receptors signals darkness to the brain, promoting sleep onset and synchronizing circadian rhythms. Exogenous melatonin raises plasma levels, reinforcing the natural night‑time signal and facilitating sleep initiation.

Side Effects

Orimelan may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Drowsiness
  • Headache
  • Dizziness
  • Nausea

Serious or Rare Side Effects

  • Allergic reaction (rash, itching, swelling)
  • Severe hypotension
  • Mood changes or depression

Precautions & Warnings

  • When using Orimelan, consider the following precautions to ensure safe and effective use.
  • Consult healthcare provider before use: especially if pregnant, nursing, or having chronic medical conditions.
  • Avoid operating machinery or driving if drowsy: melatonin can cause residual sedation.
  • Do not combine with other sedatives without medical advice: risk of excessive CNS depression.
  • Use caution in patients with depression or mood disorders: melatonin may affect mood.
  • Store at ambient temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Orimelan can interact with other medicines, requiring attention to avoid adverse effects.

Major Interactions (Avoid)

  • Alcohol: may increase sedation and impair alertness.
  • Benzodiazepines or other CNS depressants: additive sedative effect can be hazardous.

Moderate Interactions (Monitor Closely)

  • Antidepressants (e.g., SSRIs, MAOIs): may alter sleep architecture; monitor response.
  • Anticoagulants (e.g., warfarin): melatonin may affect platelet aggregation; check coagulation parameters.
  • CYP1A2 inhibitors (e.g., fluvoxamine): can raise melatonin plasma levels; adjust if needed.

Frequently Asked Questions

Orimelan contains melatonin, which is used as a sleep aid to help regulate the sleep‑wake cycle. It is commonly employed for short‑term management of insomnia, to alleviate jet lag after travel across time zones, and to improve sleep quality in individuals working night or rotating shifts.

Melatonin works by binding to MT1 and MT2 receptors in the brain’s suprachiasmatic nucleus. This interaction signals darkness, helping to synchronize the body’s internal clock and promote the onset of sleep. By raising circulating melatonin levels, the supplement reinforces the natural night‑time signal.

The appropriate dose of Orimelan is determined by a qualified healthcare professional based on the individual’s age, condition, and response to therapy. Patients should follow the prescriber’s instructions and not exceed the recommended amount without medical guidance.

Safety data for melatonin use during pregnancy or lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should consult their healthcare provider before using Orimelan to weigh potential benefits against any unknown risks.

To order Orimelan, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Orimelan provides melatonin, a naturally occurring hormone, whereas many other sleep‑aid products contain synthetic hypnotics such as diphenhydramine or zolpidem. Melatonin works by aligning circadian rhythms rather than directly depressing the central nervous system, often resulting in a milder side‑effect profile.

Orimelan should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in the original packaging, protect them from moisture and direct light, and ensure the container is tightly closed to maintain product stability.

Orimelan is taken orally, usually with a glass of water. It is typically taken about 30 minutes before the desired bedtime, but patients should follow the specific timing instructions provided by their prescriber.

Serious but rare risks include severe allergic reactions such as rash, swelling, or difficulty breathing, and significant hypotension. If any of these occur, medical attention should be sought immediately. Patients should also be aware of potential mood changes.

Individuals with known hypersensitivity to melatonin, those taking certain CNS depressants without medical supervision, and patients with uncontrolled depression or severe hepatic impairment should avoid using Orimelan unless directed by a healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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