Product image of Orindille (Drospirenone, Ethinylestradiol) supplied by GNH India

Orindille

Active Ingredient:
Drospirenone, Ethinylestradiol
Origin:
EU

Orindille (Drospirenone, Ethinylestradiol)

Drospirenone, the active ingredient in Orindille, is a combined oral contraceptive presented as a tablet for oral use, together with ethinylestradiol. It prevents unintended pregnancy in women of reproductive age.

GNH India supplies Orindille as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Orivas

1
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Indications & Clinical Uses

Orindille, a combined oral contraceptive, is indicated for the following clinical uses:

  • Contraception: Prevents unintended pregnancy by inhibiting ovulation and altering cervical mucus.
  • Menstrual cycle regulation: Provides regular, predictable menstrual bleeding.
  • Acne vulgaris: Reduces inflammatory acne lesions in women who also require contraception.

How It Works

  • Drospirenone is a synthetic progestogen with anti‑mineralocorticoid and anti‑androgenic activity, while ethinylestradiol is a synthetic estrogen. The combination suppresses the hypothalamic‑pituitary‑gonadal axis, inhibiting the mid‑cycle luteinizing hormone surge and preventing follicular development. It also thickens cervical mucus and alters the endometrial lining, reducing the likelihood of implantation.

Side Effects

Orindille may cause a range of adverse reactions, which are generally categorized by frequency and severity.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Headache: tension‑type or migraine‑like pain.
  • Breast tenderness: swelling or discomfort.
  • Weight gain: mild fluid retention.

Serious or Rare Side Effects

  • Venous thromboembolism: blood clots in deep veins or lungs.
  • Hypertensive crisis: severe increase in blood pressure.
  • Liver dysfunction: jaundice or abnormal liver enzymes.

Precautions & Warnings

Before prescribing Orindille, clinicians should consider the following precautions:

  • Smoking: avoid in women over 35 who smoke, due to increased thrombotic risk.
  • Cardiovascular disease: contraindicated in patients with history of stroke, myocardial infarction, or uncontrolled hypertension.
  • Migraine with aura: avoid because of elevated stroke risk.
  • Liver disease: use with caution in severe hepatic impairment.
  • Pregnancy: discontinue immediately if pregnancy is confirmed.
  • Store at ambient temperature: keep below 25 °C, in original packaging, protected from moisture and light.

Avoid Interactions

Orindille can interact with several medicines, affecting its efficacy or safety.

Major Interactions (Avoid)

  • Combined hormonal contraceptives with enzyme‑inducing anticonvulsants (e.g., carbamazepine, phenytoin): may reduce contraceptive effectiveness.
  • Rifampicin or other strong CYP3A4 inducers: significantly decrease plasma levels of drospirenone and ethinylestradiol.
  • Anticoagulants (e.g., warfarin): may increase risk of thrombosis.

Moderate Interactions (Monitor Closely)

  • Antidepressants (SSRIs, SNRIs): may increase risk of bleeding when combined with NSAIDs.
  • Antifungals (ketoconazole, itraconazole): may increase hormone levels, requiring monitoring.
  • Herbal supplements containing St. John’s wort: may reduce contraceptive efficacy.

Frequently Asked Questions

Orindille is a combined oral contraceptive that is prescribed to prevent unintended pregnancy. It is also used to regulate menstrual cycles and may be employed to treat moderate acne in women who require reliable contraception.

Drospirenone acts as a synthetic progestogen with anti‑mineralocorticoid and anti‑androgenic properties. In combination with ethinylestradiol, it suppresses the hypothalamic‑pituitary‑gonadal axis, preventing the luteinizing hormone surge, inhibiting ovulation, thickening cervical mucus and altering the endometrium to reduce the chance of implantation.

The dosing regimen for Orindille is determined by the prescribing healthcare professional. Typically, it is taken as one tablet daily at the same time each day, but the exact schedule and any break periods are set by the prescriber based on individual patient needs.

Orindille is contraindicated during pregnancy; it should be discontinued immediately if pregnancy is confirmed. While limited data exist for breastfeeding, the product is generally not recommended unless the benefits outweigh potential risks, and a healthcare provider should be consulted.

To order Orindille, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Orindille contains drospirenone, which offers anti‑mineralocorticoid and anti‑androgenic activity, potentially providing benefits such as reduced water retention and improved acne control compared with some older progestins. Efficacy in preventing pregnancy is comparable to other combined oral contraceptives when taken correctly.

Orindille tablets should be stored at ambient temperature, below 25 °C, in their original blister pack or container. Protect them from moisture, excessive heat and direct sunlight to maintain product stability throughout its shelf life.

Orindille is taken orally, usually as a single tablet each day. It is important to take the tablet at roughly the same time each day to maintain consistent hormone levels and maximize contraceptive effectiveness.

The most serious risks include venous thromboembolism, arterial thrombosis such as stroke or myocardial infarction, and hypertensive crises. Women with a history of clotting disorders, smoking over age 35, or certain cardiovascular conditions should be evaluated carefully before use.

Orindille should not be used by women who are pregnant, have known or suspected breast cancer, have a history of thromboembolic events, uncontrolled hypertension, severe liver disease, or who are smokers over 35 years of age. Consultation with a healthcare professional is essential to assess suitability.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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