Orkambi 200/125ge (Lumacaftor + Ivacaftor Tablet) 200mg/125mg

ORKAMBI 200/125GE (Lumacaftor + Ivacaftor) tablets combine two active ingredients to support respiratory health. This medication is designed for oral use and comes in a 112-tablet pack. Suitable for ambient storage, it addresses common concerns in cystic fibrosis management.

Strength

200mg/125mg

Pack Size

112s

Storage

Ambient

Manufacturer / TM Owner

Vertex Pharmaceuticals

Select Quantity

Pack/s

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Indications & Clinical Uses

ORKAMBI 200/125GE is used to treat cystic fibrosis in patients who have specific gene mutations. It works by improving the function of a protein that helps regulate salt and water movement in the body. This medication may help reduce symptoms like breathing difficulties and lung infections. It is prescribed for those with two copies of the F508del mutation in the CFTR gene.

Side Effects

Patients taking ORKAMBI 200/125GE may experience improved breathing and fewer respiratory symptoms over time. Some individuals report reduced coughing and better overall lung function. Digestive comfort, such as less bloating or stomach pain, can also occur as the medication takes effect. Regular use may contribute to better daily activity levels.

Precautions & Warnings

Store ORKAMBI 200/125GE at room temperature, away from moisture and heat. Keep the medication in its original packaging until ready to use. Inform your healthcare provider about any ongoing medications or health conditions before starting this treatment. Avoid crushing or splitting tablets unless advised by a medical professional.

Avoid Interactions

ORKAMBI 200/125GE may interact with certain medications, including some antibiotics, antifungals, and seizure treatments. Grapefruit products can affect how the body processes this medication, so it’s best to avoid them. Always review your current medications with a healthcare provider to minimize risks. Hormonal contraceptives may also be less effective while taking this drug.

Frequently Asked Questions

It is used to treat cystic fibrosis in patients with specific gene mutations, helping improve lung function and reduce symptoms.

Store at room temperature in a dry place, away from direct light and heat sources.

Consult your healthcare provider before combining it with other drugs, as interactions are possible.

Some users report nausea, headache, or changes in breathing, but effects vary by individual.

It is prescribed for cystic fibrosis patients with specific genetic markers, typically determined by a doctor.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated: 29 Jul 2026

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