Product image of Orlistat Sandoz (Orlistat) supplied by GNH India

Orlistat Sandoz

Active Ingredient:
Orlistat
Origin:
EU

Orlistat Sandoz (Orlistat)

Orlistat, the active ingredient in Orlistat Sandoz, is a lipase inhibitor presented as a tablet for oral use. It reduces dietary fat absorption and is used in the management of obesity and overweight in adults.
GNH India supplies Orlistat Sandoz as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Sandoz N.V.

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

Orlistat is indicated for the treatment of obesity and overweight conditions, acting on the gastrointestinal absorption of dietary fat.

  • Obesity: assists in weight loss when combined with a reduced‑calorie, low‑fat diet.
  • Overweight: supports modest weight reduction in adults with a BMI of 27–30 kg/m² who have weight‑related risk factors.
  • Weight management: used as part of a comprehensive lifestyle program that includes diet, exercise and behavioral changes.

How It Works

  • Orlistat binds covalently to the active site of gastric and pancreatic lipases, inhibiting their ability to hydrolyze dietary triglycerides. This blockade reduces the breakdown and subsequent absorption of dietary fat by approximately 30%, leading to increased fecal fat excretion and a negative caloric balance that supports weight loss.

Side Effects

Orlistat may cause gastrointestinal and nutritional adverse reactions.

Common Side Effects

  • Oily spotting: oily discharge on underwear after bowel movements.
  • Flatulence with discharge: increased gas accompanied by oily stool.
  • Fecal urgency: sudden need to defecate.
  • Abdominal cramps: intermittent stomach pain.
  • Increased defecation frequency: more frequent bowel movements.
  • Fatty/oily stool: pale, oily stools.

Serious or Rare Side Effects

  • Liver injury: rare cases of hepatitis or hepatic dysfunction.
  • Severe allergic reactions: rash, swelling, or anaphylaxis.
  • Fat‑soluble vitamin deficiency: reduced absorption of vitamins A, D, E, K.
  • Pancreatitis: inflammation of the pancreas.
  • Intestinal obstruction: blockage of the bowel.

Precautions & Warnings

Before initiating therapy, several safety considerations should be addressed.

  • Assess BMI: confirm patient meets BMI criteria for obesity or overweight treatment.
  • Dietary fat intake: advise a low‑fat diet (≤30 g per meal) to minimize gastrointestinal side effects.
  • Vitamin supplementation: recommend a multivitamin containing vitamins A, D, E and K taken at least 2 hours apart from the drug.
  • Pregnancy and lactation: avoid use unless the potential benefit justifies the potential risk to the fetus or infant.
  • Drug interactions: review concomitant medications such as cyclosporine, warfarin and levothyroxine for possible interaction.
  • Store at room temperature: keep in the original container, protect from moisture and heat.

Avoid Interactions

Orlistat can affect the absorption of several drugs and nutrients.

Major Interactions (Avoid)

  • Cyclosporine: reduced absorption may lower immunosuppressive efficacy.
  • Warfarin: increased INR; monitor coagulation parameters closely.
  • Levothyroxine: decreased absorption; separate dosing by at least 4 hours.

Moderate Interactions (Monitor Closely)

  • Antidiabetic agents: enhanced glycemic control may increase hypoglycemia risk.
  • Fat‑soluble vitamins: decreased absorption; supplement as needed.
  • Oral contraceptives: potential reduction in hormone levels; consider alternative contraception.

Frequently Asked Questions

Orlistat Sandoz is a prescription medication used to aid weight loss in adults with obesity (BMI ≥ 30 kg/m²) or overweight (BMI ≥ 27 kg/m²) who have weight‑related health risks. It works as part of a comprehensive weight‑management program that includes a reduced‑calorie, low‑fat diet, regular physical activity and behavioral changes.

Orlistat inhibits gastric and pancreatic lipases, the enzymes responsible for breaking down dietary triglycerides. By blocking these enzymes, about 30 % of the fat from a meal is not hydrolyzed and therefore cannot be absorbed, leading to increased fat excretion in the stool and a reduction in caloric intake.

The prescribed dose of Orlistat Sandoz is determined by the treating physician based on the patient’s clinical condition, body weight and response to therapy. Typically, the medication is taken orally with each main meal that contains fat, but the exact regimen should follow the prescriber’s instructions.

Orlistat Sandoz is generally not recommended for use during pregnancy or while breastfeeding unless the potential benefit outweighs the possible risk to the fetus or infant. Women who are pregnant, planning to become pregnant, or nursing should discuss alternative weight‑management strategies with their healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity of Orlistat Sandoz. GNH India supplies hospitals, pharmacies and procurement teams worldwide. After the enquiry, the sales team will request trade or institutional credentials, then provide pricing, availability, shipping details and any necessary import documentation.

Unlike appetite‑suppressing agents, Orlistat works locally in the gastrointestinal tract to reduce fat absorption, which means it does not affect the central nervous system. This mechanism results in a distinct side‑effect profile, primarily gastrointestinal, and it does not carry the cardiovascular or psychiatric risks associated with some other anti‑obesity drugs.

Orlistat Sandoz tablets should be stored at room temperature, below 25 °C, in the original blister pack or container. Keep the product away from moisture, direct sunlight and heat sources to maintain stability and potency throughout its shelf life.

Orlistat Sandoz is taken orally with a meal that contains dietary fat, typically three times daily. The tablets should be swallowed whole with water; they should not be crushed, chewed, or taken on an empty stomach, as the drug’s effect depends on the presence of fat in the gastrointestinal tract.

The most serious risks include rare cases of severe liver injury, acute pancreatitis and significant fat‑soluble vitamin deficiencies, which can lead to complications such as coagulopathy or bone health issues. Patients should be monitored for signs of hepatic dysfunction, abdominal pain, or unexplained bruising, and vitamin supplementation is advised.

Orlistat Sandoz should not be used by individuals with chronic malabsorption syndromes, cholestasis, or those who are allergic to Orlistat or any of the tablet’s excipients. It is also contraindicated in pregnant or breastfeeding women unless a physician determines that the benefits outweigh the risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.