Orlistat Sandoz (Orlistat)

Orlistat is indicated for the management of obesity and related weight‑management pathways.

• Overweight adults: Helps achieve clinically significant weight loss when combined with a reduced‑calorie, low‑fat diet.
• Obese adults: Supports weight reduction and maintenance as part of a comprehensive weight‑management program.
• Overweight adolescents (12 years and older): Assists in weight loss when used with dietary counseling.
• Post‑bariatric surgery patients: Aids in managing residual fat absorption.
• Individuals with hyperlipidaemia secondary to excess dietary fat: Contributes to lowering fat intake.
• Patients with metabolic syndrome: Complements lifestyle interventions to improve weight‑related outcomes.

• Orlistat acts as a reversible inhibitor of gastric and pancreatic lipases. By binding to the active site of these enzymes, it prevents the hydrolysis of dietary triglycerides into absorbable free fatty acids, thereby reducing the amount of fat that is absorbed from the gastrointestinal tract.

Orlistat may cause a range of gastrointestinal and systemic reactions.

Common Side Effects

• Oily spotting: Occurs on under‑clothing.
• Flatulence with discharge: Often oily or fatty.
• Fecal urgency: Increased frequency of bowel movements.
• Abdominal cramping: Discomfort in the lower abdomen.
• Fat‑soluble vitamin deficiency: Reduced absorption of vitamins A, D, E and K.
• Mild headache: Transient head discomfort.

Serious or Rare Side Effects

• Severe hepatic injury: Rare liver dysfunction.
• Acute pancreatitis: Inflammation of the pancreas.
• Allergic reactions: Rash, pruritus, or anaphylaxis.
• Kidney injury: Uncommon renal impairment.
• Persistent diarrhea: Ongoing watery stools.
• Severe malabsorption: Marked nutrient deficiencies.

Orlistat should be used with careful consideration of dietary fat intake and patient education.

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